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| 1 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 2 | ^(99m)Tc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging显示文摘The chemokine CXCR4 receptor is over-expressed in a wide variety of tumors.In this study,AMD3100,which was a prototype non-peptide antagonist of CXCR4 receptor,was labeled with ^(99m)Tc.^(99m)Tc-AMD3100 was verified by thin layer radio chromatography(TLRC).The tumor-localizing properties of ^(99m)Tc-AMD3100 were evaluated and proved in mice bearing Hep-G2 tumor xenograft.^(99m)Tc-AMD3100 was a promising,novel receptor-specific radiopharmaceutical with potential application in the imaging of human tumors. | Jin Ming Zhang~(a,),Jia He Tian~a,Tian Ran Li~a, Hai Yu Guo~a,Li Shen~b a Department of Nuclear Medicine,The PLA General Hospital,Beijing,100853,China b Peking University Health Science Center,Beijing,100191,China | 2010 | Chinese Chemical Letters2010，21，4： | 3 |
| 3 | Diagnosis of influenza in the community:relationship of clinical diagnosis to confirmed virological,serologic,or molecular detection of influenza显示文摘 | Hays J Webster A | 2001 | Arch Inter Med2001，161，17： | 1 |
| 4 | Detailed modeling of soot formation in laminar premixed ethylene flames at a pressure of 10 bar 显示文摘 | Kazakov A Wang Hai Frenklach M | 1995 | Combustion and Flame1995，100，12： | 1 |
| 5 | Measurements and correlations of the physical of CO_Wheavy crude oil mixtures显示文摘 | Chung Frank T H Jones Ray A Nguyen Hai T | 1988 | SPE Reservoir Engi- neering1988，40，8： | 1 |
| 6 | A subma- rine navigator for the 21st century 显示文摘 | HAYS K M SCHMIDT R G WILSON W A | 2002 | IEEE Position Location and Navigation Symposium2002，，： | 1 |
| 7 | The impact of irritable bowel syndrome on health-related quality of life显示文摘 | Gralnek IM Hays RD Kilbourne A | 2000 | Gastroenterology2000，119，3： | 1 |
| 8 | Mosquito cathepsin B-like protease involved in embryonic degradation of vitellin is produced as a latent extraovarian precursor显示文摘 | Cho W L Tsao S M Hays A R | 1999 | J Biol Chem1999，274，13： | 1 |
| 9 | Influ- enza viruses expressing chimeric hemagglutinins: Globu- lar head and stalk domains derived from different sub- types 显示文摘 | Hai R Krammer F Tan G S Pica N Eggink D Maamary J Margine I Albrecht R A Palese P | 2012 | J Virol2012，86，10： | 1 |
| 10 | Secretory and internalization pathways of mosquito yolk protein precursors显示文摘 | Snigirevskaya E S Hays A R Raikhel A S | 1997 | Cell Tissue Res1997，290，： | 1 |
| 11 | Infection of human cytomegalovirus in cultured human gingival tissue 显示文摘 | Hai R Chu A Li H | 2006 | Virol J2006，5，3： | 1 |
| 12 | H3n2 influenza vi- rus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice 显示文摘 | Margine I Hai R Albrecht R A Obermoser G Har-rod A C Banchereau J Palucka K Garcia-Sastre A Palese P Treanor J J Krammer F | 2013 | J Virol2013，87，8： | 1 |
| 13 | Development in high-performance liquid chromatography for high-throughput profiling and metabonomic studies of biofluid samples 显示文摘 | Kaskavelis Hai P T Daykin L Janssen C A | 2003 | J Chromatogr B2003，789，： | 1 |
| 14 | The impact of irritable bowel syndrome on health-related quality of life显示文摘 | Gralnek IM Hays RD Kilbourme A | 2000 | Gastroenterol2000，119，8： | 1 |
| 15 | Long wave ultrasound may enhance bone regeneration by altering OPGIRANKL ratio in human osteoblast-like cells显示文摘 | Maddi A Hai H Ong ST | 2006 | Bone2006，39，2： | 1 |
| 16 | Climate change and marine plankton显示文摘 | Hays G C Richardson A J Robinson C | 2005 | Trends in Ecology & Evolution2005，20，6： | 1 |
| 17 | High-power diode-array-pumped frequen cy-doubled CW Nd:YAG laser 显示文摘 | Burnham R Hays A D | 1989 | Optics Letters1989，14，： | 1 |
| 18 | The MOS short-form general health survey: reliability and validity in a patient population显示文摘 | Stewart A L Hays R D Ware J E Jr | 1988 | Med Care1988，26，7： | 1 |
| 19 | Experimentalstudy of aerodynamic noise vs drag relationships forcircular cylinders显示文摘 | REVELL J D PRYDZ R A HAYS A P | 1977 | Aiaa Journal1977，16，9： | 1 |
| 20 | Automatic generation of NC cutter path from massive data points 显示文摘 | Lin A lan C Liu Hai -Terng | 1998 | Computer - Aided Design1998，30，1： | 1 |
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