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| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | Natural occurrences of ochratoxicosis in poultry显示文摘 | Hamilton P A T B Huff W E Harris J R A Y | 1982 | Poultry Science1982，61，9： | 1 |
| 3 | Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis显示文摘 | Creticos P S Schroeder J T Hamilton R G | 2006 | N Engl J Med2006，355，： | 1 |
| 4 | Metabolism and biliary excretion of the novel anticancer agent 10-hydroxycamptothecin in the isolated perfused rat liver显示文摘 | Platzer P Thalhammer T Reznicek G Hamilton G Zhang R Jager W | 2001 | Int J Oncol2001，19，： | 1 |
| 5 | Rapid analysis of genetic variation in Atlantic salmon ( Salmo salar) by PCR multiplexing of dinucleotide and tetranucleotide microsatellites 显示文摘 | O' Reilly P T Hamilton L C McConnell S K | 1996 | Can J Fish Aquat Sci1996，53，10： | 1 |
| 6 | Immunotherapy with a ragweed-toll like receptor 9 agonist vaccine for allergic rhinitis显示文摘 | CRETICOS P S SCHROEDER J T HAMILTON R G | 2006 | N Engl J Med2006，355，： | 1 |
| 7 | Removal of saxitoxinsfrom drinking water by granular activated carbon, ozone andhydrogen peroxide-implications for compliance with the Australian drinking water guidelines 显示文摘 | Orr P T Jones G J Hamilton G R | 2004 | Water Research2004，38，20： | 1 |
| 8 | Protonated fluorine,HF2+ : Ab initio potential energy surface and vibrational splittings for proton transfer 显示文摘 | CHAN W T HAMILTON I P | 1998 | J Chem Phys1998，109，： | 1 |
| 9 | Effects of storage and processing on pesticide residues in plant products 显示文摘 | Holland P T Hamilton D Ohlin B | 1994 | Pure & applied chemistry1994，66，2： | 1 |
| 10 | Effect of freshwater flow on the succession and biomass of phytoplankton in a seasonal estuary显示文摘 | CHAN T HAMILTON P | 2001 | Marine and Freshwater Research2001，52，6： | 1 |
| 11 | Removal of saxitoxins from drinking water by granular activated carbon, ozone and hydrogen peroxide-implications for compliance with the Australian drinking water guidelines显示文摘 | ORR P T JONES G J HAMILTON G R | 2004 | Water Research2004，38，： | 1 |
| 12 | Improving power production in acetate-fed microbial fuel cells via enrichment of exoelectrogenic organisms in flow-throgh systems 显示文摘 | Borole A P Hamilton C Y Vishnivetskaya T | 2009 | Biochemical Engineering Journal2009，48，： | 1 |
| 13 | Does treatment at the time of locoregional failure of breast cancer alter prognosis显示文摘 | Clemons M Hamilton T Goss P | | 0，，02： | 1 |
| 14 | Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis显示文摘 | CRETICOS P S SCHROEDER J T HAMILTON R G | 2006 | N Engl J Med2006，355，14： | 1 |
| 15 | Removal of saxitoxins from drinking water by granular activated carbon,ozone and hydrogen peroxide-implications for compliance with the Australian drinking water guidelines显示文摘 | Orr P T Jones G J Hamilton G R | | 0，，20： | 1 |
| 16 | Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis显示文摘 | CRETICOS P S SCHROEDER J T HAMILTON R G | 2006 | N Engl J Med2006，355，： | 1 |
| 17 | Integrating engineering design improvements with exoelectrogen enrichment process to increase power output from microbial fuel cells 显示文摘 | BOROLE A P HAMILTON C Y VISHNIVETSKAYA T A | 2009 | Journal of Power Sources2009，191，2： | 1 |
| 18 | Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies, between previous reports 显示文摘 | CUSHNIE T P T HAMILTON V E S LAMB A J | 2003 | Microbiological Research2003，158，： | 1 |
| 19 | Immunosuppression in chickens by aflatoxin显示文摘 | Thaxton P Tung H T Hamilton P B | 1974 | Poult Sci1974，53，： | 1 |
| 20 | Rapid analysis of genetic variation in Atlantic salmon (Salmo salar) by PCR multiplexing of dinucleotide and tetranucleotide microsatellites显示文摘 | O’Reilly P T Hamilton L C McConnell S K | 1996 | Canadian Journal of Fisheries and Aquatic Sciences1996，53，10： | 1 |
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