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217篇 您的检索式：作者名="Han E T"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	A finite element model for 2-dimensional slice of cast strand显示文摘	Han H N Lee J E Yeo T J	1999	ISIJ Int1999，39，5：	1
3	Four prodator- prey models with infectious diseases 显示文摘	HAN L T MA Z E HETHCOTE H W	2001	Mathl Comput Modelling2001，34，：	1
4	NEPTUNE Study: On-treatment HBsAg level analysis confirms prediction of response observed in phase 3 study of peginterferon alfa-2a in HBeAg-positive patients 显示文摘	Gane E Jia J Han K Tanwandee T Chuang WL Marcellin P Chan HL Piratvisuth T Wat C Martins E Liaw YF	2011	J Hepatol2011，54，：	1
5	Obesity and weight management in the elderly:a focus on men显示文摘	Han T S Wu F C Lean M E	2013	Best Practice&Research Clinical Endocrinology&Metabolism2013，27，4：	1
6	Application of dispersive liquid-liquid microextraction for the analysis of organophosphorus pesticides in watermelon and cucumber显示文摘	Zhao E C Zhao W T Han L J		0，，1：	1
7	Dosimetric comparisons of helical tomotherapy treatment plans and step-and-shoot intensity modulated radiosurgery Ireatment plans in intracranial stereotactic radiosurgery显示文摘	Han C Liu A Schultheiss T E	2006	Int J Radiat Oncol Biol Phys2006，65，2：	1
8	Development of the pen tile matrix color AMLCD sub-pixel architecture and rendering algorithms 显示文摘	Brown E C H Credelle T L Han S	2003	Journal of the SID2003，11，1：	1
9	Pervaporation of dilute organic-wa- ters mixtures A literature review on modelling studies and ap- plieations to aroma compound reeovery显示文摘	Karlsson Hans O E Gun T	1993	J Membr Sci1993，76，23：	1
10	Atreatment algorithm for the manageraent of chronic hepatitis B virus infection in the United States: an update 显示文摘	KEEFFE E B DIETERICH D T HAN S H	2006	Clin Gastreenterol Hepatol2006，4，8：	1
11	Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial显示文摘	Stevo Julius Sverre E Kjeldsen Michael Weber Hans R Brunner Steffan Ekman Lennart Hansson Tsushung Hua John Laragh Gordon T McInnes Lada Mitchell Francis Plat Anthony Schork Beverly Smith Alberto Zanchetti	2004	The Lancet2004，，9426：	1
12	A Finite Element Model for 2-Dimensional Slice of Cast Strand显示文摘	Han H N LeeJ E Yeo T J	1999	ISIJ International1999，39，5：	1
13	A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 Update显示文摘	Keeffe E B Dieterich D T Han S H	2008	Clin Gastroenterol Hepatol2008，6，12：	1
14	A comparative analysis of urban and rural residential thermal comfort under natural ventilat- ion environment显示文摘	Jie Han Wei Yang Jin Zhou e t al		0，，：	1
15	Expression and functionalcharacterization of three squalene synthase genes associated withsaponin biosynthesis in Panax ginseng 显示文摘	Kim T D Han J Y Huh G H e? al	2011	Plant Cell Physiol2011，52，1：	1
16	Bale density and moisture effects on alfalfa round bale silage显示文摘	Han K J Collins M Vanzant E S Dougherty C T	2004	Crop Sci2004，44，3：	1
17	Va lproi c a c id promot e sdifferentiation of hepatocyte-like cells from whole humanumbilical cord-derived mesenchymal stem cells显示文摘	An SY Han J Lim HJ e t a l	2014	Tissue Cell2014，46，2：	1
18	The Limited Immunomodulatory Effects of Escharectomy on the Kinetics of Endotoxin,Cytokines,and Adhesion Molecules in Major Burns显示文摘	Han T H Lee S Y Kwon J E	2004	Mediators Inflamm2004，13，4：	1
19	Luteolin inhibits the nuclear factor-KB transcriptional activity in Rat-1 fibroblasts显示文摘	KIM S H SHIN K J KIM D KIM Y H HAN M S LEE T G KIM E RYU S H SUH P G	2003	Biochemical Pharmacology2003，66，6：	1
20	Antioxidative enzymes offer protection from chilling damage in rice plants显示文摘	KUK Y I SHIN J S BURGOS N R HWANG T E HAN O CHO B H JUNG S GUH J O	2003	Crop Science2003，43，6：	1

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