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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | 残余应力导致三层聚烯烃管道防腐层剥离与开裂显示文摘这是美国运输部发起的研究项目,一个管道防腐层专家团队参与了本研究项目,评价了三层聚烯烃管道外防腐涂层(3LPO)的完整性。研究表明,三层聚烯烃管道外防腐涂层(3LPO)存在剥离和面层开裂两大完整性问题。过去几年里,据文献报道,三层聚烯烃管道外防腐涂层(3LPO)的熔结环氧粉末(FBE)底漆与钢管界面上发生多起防腐层剥离事故,以及聚丙烯(PP)面层发生开裂事故。这些防腐层事故引起人们对使用三层聚烯烃管道外防腐涂层(3LPO)的关注。一般来讲,三层聚烯烃管道外防腐涂层(3LPO)采用比较厚的聚烯烃面层增强防腐层抗机械损伤和防止水渗透的能力。但是,聚烯烃的热膨胀系数比钢材高得多,结果在防腐层系统里产生比较高的残余热应力。因为残余应力高,造成防腐层剥离,尤其在管端截短防腐层和任何防腐层的边上,因为这些是高应力集中部位。特别是假如钢管表面预处理不当,就无法保证防腐层持久达到很强的粘合强度。如果熔结环氧粉末(FBE)底漆配方选择不当,发生热氧化降解,也导致防腐层过早失效。如果使用温度很高,聚丙烯也会因为热氧化降解而变脆。在残余应力下,这样脆性的聚丙烯面层就会开裂。本文分析了三层聚烯烃管道外防腐涂层(3LPO)中的残余应力,并且探讨了残余应力对三层聚烯烃管道外防腐涂层(3LPO)剥离和聚丙烯(PP)面层开裂机理的影响。 | B.T.A.Cheng S Hung-jue J Han D Wong A Kehr M Mallozzi F Aguirre H Pham W Snider 王向农(译) | 2011 | 防腐保温技术2011，19，3： | 3 |
| 4 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 5 | Nestin-positive mesenchymal stem cells favour the astroglial lineage in neural progenitors and stem cells by releasing active BMP4显示文摘 | Bruyère F Hans G | 2004 | BMC Neurosci2004，5，： | 1 |
| 6 | A new method to improve in-bore middle cerebral artery occlusion in rats:demonstration with diffusion-and perfusion-weighted imaging显示文摘 | LI F HAN S TATLISUMAK T | 1998 | Stroke1998，29，8： | 1 |
| 7 | Lipid-based Formulations to Enhance Oral Bioavailability of the Poorly Water-sol- uble Drug Anethol Trithione: Effects of Lipid Composition and Formulation显示文摘 | Han S F Yao T T Zhang X X | 2009 | International Journal of Pharmaceutics2009，379，1： | 1 |
| 8 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 9 | Preparation and antimicrobial activity of hydroxypropyl chitosan显示文摘 | Peng Y F Han B Q Liu W S | 2005 | Carbohydrate Research:2005，340，11： | 1 |
| 10 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 11 | Analysis of clinical and dosimetric factors influencing radiation-induced lung injury in patients with lung cancer 显示文摘 | Han S Gu F Lin G | 2015 | Journal of Cancer2015，6，11： | 1 |
| 12 | The mechanism of Acetobacter Xylinum cellulose biosynthesis: direction of chain elongation and the role of lipid pyrophosphate intermediates in the cell membrane显示文摘 | HAN N S Robyt J F | 1998 | Carbohydrate Research1998，313，： | 1 |
| 13 | A novel method for incorporation of heteroatoms into the framework of ordered mesoporous silica materials synthesized in strong acidic media显示文摘 | HAN Y XIAO F S WU S | 2001 | J Phys Chem B2001，105，： | 1 |
| 14 | Membrane aromatic recovery system (MARS) - a new membrane process :for the recovery of phenols from wastewaters显示文摘 | Han S Ferreira F C Linvingston A G | 2001 | J Membr Sci2001，188，： | 1 |
| 15 | Continuous biohydrogen production in a CSTR using starch as a substrate 显示文摘 | Shin H S Arooj M F Han S K | 2008 | International Journal of Hydrogen Energy2008，33，13： | 1 |
| 16 | Distribution and pathogenicity of bacteria species carried by Bursaphelenchus xylophilus in China显示文摘 | Zhao B G Wang H L Han S F | 2003 | Nematology2003，5，6： | 1 |
| 17 | MicroRNA-100 regulates neovascularization by suppres- sion of mammalian target of rapamycin in endothelial and vas- cular smooth muscle cells 显示文摘 | Grundmann S Hans FP Kirmiry S Heinke J Helbing T Blubm F et 02 | 2011 | Circulation2011，123，9： | 1 |
| 18 | High-efficiency-sensitized solar cell with a novel co-adsorbent显示文摘 | Han L Y Islam A Chen H Malapaka C Chiranjeevi B Zhang S F Yang X D Yanagida M | | 0，，03： | 1 |
| 19 | Non-catalytic CVD preparation of carbon spheres with a specific size显示文摘 | Qian H S Han F M Zhang B | | 0，，04： | 1 |
| 20 | Isolstion and characterization of methicillin-resistant Staphylococcus aureus strains from Louisiana retail meats显示文摘 | Pu S Han F Ge B | | 0，，01： | 1 |
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