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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Relationship between diabetes mellitus and cataract in Hungary显示文摘AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in Hungary.The effects of DM on the cataract surgical results were also in the focus of analysis.METHODS:Statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in 2015.This cross-sectional,population-based,national survey included 3523 people aged 50 years and over.Participants of the survey were examined on-site.Visual acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were examined.RESULTS:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with age.Among the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,P<0.001),DM proved to be the most independent influencing risk factor(OR=49.9%,P<0.001).The presence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual acuity.CONCLUSION:DM appears to be one of the main risk factors for developing cataract.Other risk factors,such as age,sex and environment also play an influencing role.Diabetes does not seem to affect the occurrence of cataract surgical complications. | Anita Pék Dorottya Szabó Gábor LászlóSándor Gábor Tóth András Papp Zoltán Zsolt Nagy Hans Limburg János Németh | 2020 | International Journal of Ophthalmology(English edition)2020，13，5： | 2 |
| 3 | A high efficiency ZVS PWM asymmetrical half bridge converter for plasma display panel sustaining power module显示文摘 | Han S K Moon G W Youn M J | 2004 | 35th Annual Power Electronics Specialists Conference Aachen Germany2004，，： | 1 |
| 4 | Dictyoquinazols A,B,and C,new neuroprotective compounds from the mushroom Dictyophora indusiata显示文摘 | LEE I K YUN B S HAN G | 2002 | Journal of Natural Products2002，65，12： | 1 |
| 5 | 查看详情显示文摘 | Zhang J P Yang H P Han K L Deng W Q He G Z Lou N Q | | 0，，： | 1 |
| 6 | A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis显示文摘 | Ren D Liu Y Yang K Y Han L Mao G Glazebrook J Zhang S | | 0，，： | 1 |
| 7 | Ovality defect control for round cast-ing based on mechanical deformation analysis 显示文摘 | Han Z G Liu K Zhang J Q | 2011 | Advanced Ma-terials Research2011，，： | 1 |
| 8 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 9 | Effects of vanadium addition on nucleation and growth of pearlite in high carbon steel 显示文摘 | Han K Mottishaw T D Smith G D W | 1994 | Mater Sci Technol1994，10，11： | 1 |
| 10 | Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery 显示文摘 | HAN W K WAGENER G ZHU Y | 2009 | Clin J Am Soe Nephrol2009，4，： | 1 |
| 11 | Urinary biomarkersin the early detection of acute kidney injury after cardiacsurgery 显示文摘 | HAN W K WAGENER G ZHU Y | 2009 | Clin J Am Soc Nephrol2009，4，5： | 1 |
| 12 | Molecular genetiC diversity and population structure in Lycium accessions using SSR markers显示文摘 | Zhao W G Chung J W Cho Y I Rha W H Lee G A Ma K H Han S H Bang K H Park C B Kim S M Park Y J | 2010 | C R Bioi2010，333，： | 1 |
| 13 | Opioid rotation in the man-agement of chronic pain:where is the evidence显示文摘 | Vissers KCP Besse K Hans G | 2010 | Pain Pract2010，2，： | 1 |
| 14 | Development and evaluation of a risk communication curriculum for medical students显示文摘 | HAN P K JOEKES K ELWYN G | 2014 | Patient Educ Couns2014，94，1： | 1 |
| 15 | Identification of lung cancer patients by serum protein profiling using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry 显示文摘 | Han K Q Huang G Gao C F | 2008 | Am J Clin Oncol2008，31，2： | 1 |
| 16 | Bone dowels in anterior lumbar interbody fusion显示文摘 | Lekovic G P Han P P Kenny K J Dickman C A | 2007 | J Spinal Disord Tech2007，20，： | 1 |
| 17 | Three AFLP markers tightly linked to the genic male sterility ms3 gene in chili pepper (Capsicum annuum L) and conversion to a CAPS marker显示文摘 | Lee J Yoon J B Han J H Lee W P Hoon K S Park H G | 2010 | Euphytica2010，173，： | 1 |
| 18 | Warm deformation behavior of hot-rolled AZ31 Mg alloy 显示文摘 | YIN D L ZHANG K F WANG G F HAN W B | 2005 | Materials Science and Engineering A2005，392，： | 1 |
| 19 | An accurate higherorder Taylor-Galerkin method for structural dynamics 显示文摘 | YOUN S K HANS G | 1993 | Computers & Structures1993，48，： | 1 |
| 20 | Synthesis of dimethyl carbonate from CH3OH and CO2 with Ce1-xZrx O2 catalysts 显示文摘 | Han G B Park N K Jun J H | 2004 | Studies in Surface Science and Catalysis2004，153，： | 1 |
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