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| 1 | Hepatocellular carcinoma surveillance:An evidence-based approach显示文摘Hepatocellular carcinoma(HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound(US) given that it is cost effective and noninvasive with good sensitivity. However, US is limited in obese patients and those with non-alcoholic fatty liver disease(NAFLD). With the current obesity epidemic and rise in the prevalence of NAFLD, abdominal computed tomography or magnetic resonance imaging may be indicated as the primary screening modality in these patients. The addition of alpha-fetoprotein to a surveillance regimen is thought to improve the sensitivity of HCC detection.Further investigation of serum biomarkers is needed. Semiannual screening is the suggested surveillance interval. Surveillance for HCC is underutilized and low adherence disproportionately affects certain demographics such as nonCaucasian race and low socioeconomic status. | Patrick S Harris Ross M Hansen Meagan E Gray Omar I Massoud Brendan M McGuire Mohamed G Shoreibah | 2019 | World Journal of Gastroenterology2019，25，13： | 31 |
| 2 | 微创腰椎间盘分流术治疗椎间盘源性腰痛显示文摘目的探讨微创腰椎间盘分流术治疗椎间盘源性腰痛的作用机制并分析其近期临床疗效。方法通过体外实验测定尼龙线分流虹吸管作用的距离;动物椎问盘内置入尼龙线,其尾端埋于肌肉中,组织学检查尼龙线的生物相容性。15例经椎间盘造影诊断为椎间盘源性腰痛,局麻下行腰椎间盘分流术(应用特别设计的工具将尼龙线置人腰椎间盘内),L3-4例、L4-5,6例、L5s17例、L3-4合并L4-5,1例。术后1周、3、12和24个月采用疼痛视觉模拟评分(visualanalogueseale,VAS)、Oswestry功能障碍指数(Oswestrydisabilityindex,ODI)和影像学检查综合评估临床疗效。结果体外实验显示通过尼龙线可将乳酸溶液的pH值从低于4.0调高至7.14;体内实验表明绵羊椎问盘置人尼龙线后,椎问盘内蛋白多糖的含量随着时间推移逐渐增加,且尼龙线周围无炎症反应。所有患者均成功施行腰椎间盘分流术,无手术并发症。术后2年随访,患者VAS评分与ODI评分均有明显下降,VAS改善率达79.16%±12.33%,ODI改善率为77.42%±12.20%;X线片示术后2年椎间盘高度指数与术前相比,差异无统计学意义;MRI示根据改良Thompson分级,分流椎间盘的退变程度无加重,10例患者髓核信号有一定程度的增强。结论经皮腰椎问盘分流术能够明显缓解腰痛,改善腰背部功能,具有创伤小,风险低的优点,有望成为临床治疗椎问盘源性腰痛一种新的微创手术方式。 | 史金辉 杨炎 周峰 张洪涛 王震 王根林 姜为民 杨惠林 唐天驷 Jeffrey E Yeung Hansen A Yuan | 2014 | 中华骨科杂志2014，34，8： | 7 |
| 3 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 4 | Immunoreactivity of CD45,a protein phosphotyrosine phosphatase,in Alzheimer' s disease 显示文摘 | Masliah E Mallory M Hansen L Alford M Albright T Terry R | 1991 | Acta Neuropathol( Berl )1991，83，1： | 2 |
| 5 | Acoustic method for quality control and in-service periodic monitoring of medium voltage cable terminations 显示文摘 | LUNDGAARD L E HANSEN W | 1998 | Electrical Insulation1998，1，： | 1 |
| 6 | A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion显示文摘 | Hansen C L Skordalakes E Berger J M | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 7 | Effect of dietary protein restriction of progression in patients with diabetic nephropathy显示文摘 | Hansen HP Tauber-Lassen E Jensen BR | 2002 | Kidney Int2002，62，： | 1 |
| 8 | Analysis of orbital T cells in thyroid-asssociated ophthalmopathy显示文摘 | Forster G Otto E Hansen C | 1998 | Clin Exp Imunol1998，11，2： | 1 |
| 9 | Method for determination of methane potentials of solid organic waste显示文摘 | Hansen T L Schmidt J E Angelidaki l | 2004 | Waste Management2004，24，： | 1 |
| 10 | De Novo Biosynthesis of Vanillin in Fission Yeast (Schizosaccharomyces i?ombe) and Bakers Yeast (Saccharomyces cerevisiae)显示文摘 | Hansen E H Moiler B L Koek G R | 2009 | Applied md Environmentalmicrobiology2009，75，9： | 1 |
| 11 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 12 | Designing Realised Kernels to Measure the Ex-Post Variation of Equity Prices in the Presence of Noise显示文摘 | Barndorff-Nielsen O E Hansen P R Lunde A Shephard N | 2008 | Econometrica2008，76，： | 1 |
| 13 | Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development显示文摘 | Hansen L A Alexander N Hogan M E Sundberg J P Dlugosz A Threadgill D W Magnuson T Yuspa S H | | 0，，06： | 1 |
| 14 | Bilirubin induces apoptosis and necrosis in human NT2-N neurons显示文摘 | Hanko E Hansen TW Almaas R | | 0，，02： | 1 |
| 15 | Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethyl- hexyl) phthalate and ovalbumin in BALB/e mice 显示文摘 | Larsen S T Hansen J S Hansen E K | 2007 | Toxicology2007，235，： | 1 |
| 16 | Acute interstitial pneumonia in mink kits inoculated with defined isolates of Aleutian mink disease parvovirus显示文摘 | Alexandersen S Larsen S Aasted B Uttenthal A Bloom M E Hansen M | 1994 | Vet Patho1994，31，2： | 1 |
| 17 | Sample splitting and threshold estimation显示文摘 | HANSEN B E | 2000 | Econometrica2000，68，3： | 1 |
| 18 | Diagnosticmethods for fast-track identification of endometrial cancerin women with postmenopausal bleeding and endometrialthickness greater than 5 mm 显示文摘 | Dueholm M Marinovskij E Hansen ES | 2015 | Menopause2015，22，6： | 1 |
| 19 | Threshold effects in non-dynamic panels: estimation, testing and inference 显示文摘 | HANSEN B E | 1999 | Journal of econometrics1999，93，： | 1 |
| 20 | Effect of different holding regimens on the intestinal microfora of herring (Clupea harengus) larvae显示文摘 | HANSEN G H STREM E OLAFSEN H A | 1992 | Appl Environ Microbial1992，58，： | 1 |
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