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| 1 | Hepatocellular carcinoma surveillance:An evidence-based approach显示文摘Hepatocellular carcinoma(HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound(US) given that it is cost effective and noninvasive with good sensitivity. However, US is limited in obese patients and those with non-alcoholic fatty liver disease(NAFLD). With the current obesity epidemic and rise in the prevalence of NAFLD, abdominal computed tomography or magnetic resonance imaging may be indicated as the primary screening modality in these patients. The addition of alpha-fetoprotein to a surveillance regimen is thought to improve the sensitivity of HCC detection.Further investigation of serum biomarkers is needed. Semiannual screening is the suggested surveillance interval. Surveillance for HCC is underutilized and low adherence disproportionately affects certain demographics such as nonCaucasian race and low socioeconomic status. | Patrick S Harris Ross M Hansen Meagan E Gray Omar I Massoud Brendan M McGuire Mohamed G Shoreibah | 2019 | World Journal of Gastroenterology2019，25，13： | 31 |
| 2 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 3 | The first X-ray structural evidence demonstrating thiolate coordination in an organocobalt B12 model complex:implications for methionine syntheses显示文摘 | Polson S M Hansen L Marzilli L G | 1997 | Inorg Chem1997，36，2： | 1 |
| 4 | Enforced mobilization,early oral feeding, and balanced analgesia improve convalescence after colorectal surgery 显示文摘 | Henriksen M G Jensen M B Hansen H V | 2002 | Nutrition2002，18，2： | 1 |
| 5 | Pharmacokinetics of mycophenolatemofetil for autoimmune disease in children显示文摘 | FILLER G HANSEN M LEBLANC C | 2003 | Pediatr Nephrol2003，18，5： | 1 |
| 6 | Intraosseous line use, complications, and outcomes among a population-based cohort of children presenting to California hospitals 显示文摘 | Hansen M Meckler G Spiro D | 2011 | Pediatr Emerg Care2011，27，10： | 1 |
| 7 | Pharmacokinetics of mycophenolate mofetil for autoimmune disease in children显示文摘 | Filler G Hansen M LeBlanc C | 2003 | Pediatr Nephrol2003，18，5： | 1 |
| 8 | Bioassay of prostate - specific antigen (PSA) using microcantilevers 显示文摘 | WU G H DATAR R H HANSEN K M | 2001 | Nature Biotechnology2001，19，9： | 1 |
| 9 | Early life-stage toxicity test methods for gulf toadfish ( Opsanus beta) andresults using chlorpyrifos显示文摘 | HANSEN D J GOODMAN L R CRIPE G M | 1986 | Ecoloxicology and EnvironmentalSafety1986，11，1： | 1 |
| 10 | Recent advances in the transformation of plants显示文摘 | HANSEN G WRIGHT M S | 1999 | Trends Plant Sci1999，4，： | 1 |
| 11 | Phosphomannose isomerase:an efficient selectable marker for plant transformation显示文摘 | Reed J Privallel L Powell M L Meghji M Dawson J Dunder E Suttie J Wenck A Launis K Kramer C Chang Y F Hansen G Wright M | | 0，，： | 1 |
| 12 | Conjugated linoleic acid in combination with supplemental dietary fat alters pork quality显示文摘 | Averette G L See M T Hansen J A | 2002 | J Nutr2002，132，： | 1 |
| 13 | Carbonated serpentinite (listwanite) at Atlin, British Columbia: a geological analogue to carbon dioxide sequestration 显示文摘 | HANSEN L D DIPPLE G M GORDON T M | 2005 | The Canadian Mineralogist2005，43，1： | 1 |
| 14 | Collagen-derived markers of bone metabolism in osteogenesis imperfecta显示文摘 | Lund AM Hansen M Kollerup G | 1998 | Acta Paediatr1998，87，11： | 1 |
| 15 | Effect of the strength of ad- sorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response显示文摘 | Hansen B Belfast M Soung G | 2009 | Vaccine2009，27，6： | 1 |
| 16 | 'Agrolistic' transformation of plant cells:integration of T-strands generated in Planta显示文摘 | HANSEN G CHITON M D | 1996 | Proc Natl Acad Sci USA1996，93，14： | 1 |
| 17 | Feature-space clus- tering for fMRI Meta-analysis 显示文摘 | GOUTTE C HANSEN L K LIPTROT M G | 2001 | Human Brain Mapping2001，13，3： | 1 |
| 18 | Male zebrafish (Danio rerio)courtship behaviour resists the feminising effects of 17alpha-ethinyloestradiol-morpholo-gical sexual characteristics do not 显示文摘 | LARSEN M G HANSEN K B HENRIKSEN P G | 2008 | Aquatic Toxicology2008，87，4： | 1 |
| 19 | Sequence a- nalysis of porcine reproductive and respiratory syndrome virus of the American type collected from Danish swine herds 显示文摘 | Madsen K G Hansen C M Madsen E S | 1998 | Arch Virol1998，143，： | 1 |
| 20 | The first X-ray structural evidence demonstrating thiolate coordination in an organocobalt B12 model complex: Implications for methionine synthase显示文摘 | Polson S M Hansen L Marzilli L G | 1997 | Inorg Chem1997，36，： | 1 |
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