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| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | Failure of acetabular autogenous grafts in total hip arthroplasty,Increasing incidence;A follow up note显示文摘 | MULROY Jr R D HARRIS W H | 1990 | J Bone Joint Surg(Am)1990，72，： | 1 |
| 3 | The World Health Organization (WHO) classification of the myeloid neoplasms显示文摘 | Vardiman J W Harris N L Brunning R D | 2002 | Blood2002，100，7： | 1 |
| 4 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 5 | The World Health Organization (WHO) classification of the myeloid neoplasms 显示文摘 | Vardiman J W Harris N L Brunning R D | 2002 | Blood2002，100，7： | 1 |
| 6 | Molecular genetica and physiology of alcohol dehydrogenase in woody plants 显示文摘 | Harry D E Kimmerer T W | 1991 | Forest Biotechnolo- gy1991，43，34： | 1 |
| 7 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 8 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 9 | Analysis of the human pituitary proteome by data independent label-free liquid chromatography tandem mass spectrometry显示文摘 | Krishnamurthy D Levin Y Harris L W Umrania Y Bahn S Guest P C | | 0，，03： | 1 |
| 10 | Eval- uation of Instrument Leak Detection Capabilities for Smart LDAR Application: Chemical Plant Testing 显示文摘 | FURRY D W HARRIS G RANUM D etal | 2007 | EnvironProg2007，26，2： | 1 |
| 11 | Control performance assessment for Hammerstein-Wiener models显示文摘 | Yu W Wilson D I Harris T J | 2010 | Dynamics and Control of Process Sys- tems2010，11，1： | 1 |
| 12 | The Hawaii 2 observatory seismic system 显示文摘 | DUENNEBIER F K HARRIS D W JOLLY J | 2002 | IEEE Journal of Oceanic Engineering2002，27，2： | 1 |
| 13 | The digestibility and voluntary intake of S22 and h1 ryegrass ,S170 tall fescue,S48 timothy,S15 meadow fescue and germinal cooksfoot显示文摘 | Minson D j C E Harris W F Raymond | 1964 | J Brit Grassl Soc1964，19，： | 1 |
| 14 | Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expres- sion in endothelial cell function显示文摘 | Patel N S Li J L Generali D Poulsom R Cranston D W Harris A L | 2005 | Cancer Res2005，65，： | 1 |
| 15 | Screening interspecific blueberry seedling populations for drought resistance显示文摘 | Erb W A Draper A D Swartz Harry J | 1988 | Journal of the American Society for Horticultural Science1988，113，4： | 1 |
| 16 | Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study显示文摘 | Ronenn Roubenoff Helen Parise Hélène A Payette Leslie W Abad Ralph D’Agostino Paul F Jacques Peter W.F Wilson Charles A Dinarello Tamara B Harris | 2003 | The American Journal of Medicine2003，，6： | 1 |
| 17 | Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer显示文摘 | Harries L W Stubbins M J Forman D | 1997 | Carcinogenesis1997，18，4： | 1 |
| 18 | Measurement of exchangeable inorganic phosphate in lake sediments 显示文摘 | Li W C Armstrong D E Harris R F | 1973 | Environ Sci Technol1973，7，： | 1 |
| 19 | Crystal structure and mechanical properties of ODPADMB polyimide fibers显示文摘 | Kim Y H Harris F W Cheng S Z D | 1996 | Thermochim Acta1996，，： | 1 |
| 20 | Cloning and char acterization of zona pellucida genes and cDNAs from a variety of mammalian species: The ZPA, ZPB and ZPC gene families 显示文摘 | Harris J D Hibler D W Fontenot G K | 1994 | DNA Sequence1994，4，6： | 1 |
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