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| 1 | 腹腔镜远端胃癌根治术行非离断式Roux-en-Y吻合119例分析显示文摘目的分析腹腔镜远端胃癌根治术非离断式Roux-en-Y吻合临床特点、术后并发症分布情况。方法回顾性分析吉林大学第一医院胃结直肠外科自2015年1月至2016年4月收治的共119例行腹腔镜远端胃癌根治术非离断式Roux-en-Y吻合病例资料,行相关临床观察并对术后并发症进行统计学分析。结果并发症总发生率为9.7%,围手术期胃液pH值监测均<7.0,上消化道造影见输出袢蠕动良好,无造影剂淤滞或反流,无胃瘫综合征出现,术后6 d及3个月30 min造影剂完全排空比例分别为73.1%、82.7%;术后3个月反酸和残胃炎占比分别为6.7%和32.4%。结论非离断式Roux-en-Y吻合可有效地改善毕Ⅱ式吻合的碱性反流并预防Roux-en-Y淤滞综合征,是一种安全可行的消化道重建方式,建议在临床中推广。 | 杨栋 苏同荣 何亮 佟伟华 张路遥 Harun Nur Mohamed 王权 | 2018 | 中国实用外科杂志2018，38，3： | 14 |
| 2 | Long-term results of paclitaxel plus cisplatin with concurrent radiotherapy for loco-regional esophageal squamous cell carcinoma显示文摘AIM To evaluate the long-term effectiveness and late toxicities of paclitaxel(PTX) plus cisplatin(DDP) with concurrent radiotherapy for locally advanced esophageal squamous cancer.METHODS Between 2008 and 2011, 76 patients were enrolled in a phase Ⅱ study on the treatment of loco-regionally advanced esophageal cancer with radiotherapy(68.4 Gy/44 fractions or 61.2 Gy/34 fractions) combined with 4-cycle chemotherapy consisting of DDP(25 mg/m^2 per day for 3 d) and PTX(175 mg/m^2 for 3 h). The primary endpoints were overall survival and progression-free survival, and the secondary endpoints were toxicity and the treatment failure pattern.RESULTS A total of 76 patients were enrolled in this study, of whom 63.2% finished the whole regimen. The 5-year survival rates for the per-protocol population and intent-to-treat population were 25.4% and 26.4%, respectively, and the median survival rates were 23.7 mo and 28.5 mo, respectively. Grade 3 or 4 late toxicity was observed in only one patient(heart failure). In log-rank analysis, the pretreatment stage(stage Ⅱ + Ⅲ: 36.1 mo vs stage Ⅳ: 14.9 mo) and the completed cycle(1-3 cycles: 16.1 mo vs 4 cycles: 35.5 mo) were significant prognostic factors(P = 0.037 < 0.05 and P = 0.013 < 0.05).CONCLUSION Radiotherapy combined with chemotherapy consisting of PTX and DDP is a safe and effective definitive treatment for loco-regionally advanced esophageal squamous cancer. | Han-Ting Zhu Da-Shan Ai Hua-Rong Tang Harun Badakhshi Jian-Hong Fan Jia-Ying Deng Jun-Hua Zhang Yun Chen Zhen Zhang Yi Xia Xiao-Mao Guo Guo-Liang Jiang Kuai-Le Zhao | 2017 | World Journal of Gastroenterology2017，23，3： | 14 |
| 3 | Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice显示文摘AIM:To evaluate the protective effects on kidney tissue of frequently used intravenous anesthetics(ketamine,propofol,thiopental,and fentanyl)in rats with obstructive jaundice.METHODS:There is an increased incidence of postoperative acute renal failure in patients with obstructive jaundice.Thirty-two Wistar-albino rats were randomly divided into four equal groups.Laparatomy was performed on each animal in the four groups and common bile ducts were ligated and severed on day 0.After 7 d,laparotomy was again performed using ketamine,propofol,thiopental,or fentanyl anesthesia whose antioxidative properties are well known in oxidative stress in a rat liver model of obstructive jaundice.After 2 h,the rats were sacrificed.Renal tissue specimens were analyzed for catalase,superoxide dismutase and malondialdehyde enzymes activities.All values are expressed as the mean±SD.P values less than 0.05 were considered statistically significant.RESULTS:All animals survived without complications until the end of the study.Enlargement in the bile duct and obstructive jaundice were observed in all rats.Catalase was found to be significantly lower in the fentanyl group than in the ketamine(P=0.039),propofol(P=0.012),and thiopental(P=0.001)groups.Superoxide dismutase activities were similar in all groups(P>0.05).Malondialdehyde was found to be significantly lower in the ketamine group than in the propofol(P=0.028),thiopental(P=0.002)and fentanyl(P=0.005)groups.Malondialdehyde was also lower in the fentanyl group than in the thiopental group(P=0.001).The results showed that obstructive jaundice sensitizes renal tissue to damage under the different anesthetics.CONCLUSION:Among the agents tested,ketamine and propofol generated the least amount of oxidative stres on renal tissues in this rat model of obstructive jaundice created by common bile duct ligation.The importance of free radical injury in renal tissue in obstructive jaundice under different intravenous anesthetics during hepatobiliary and liver transplant surgery should be considered for prevention of postoperative acute renal failure. | Sinan Hatipoglu Huseyin Yildiz Ertan Bulbuloglu Ismail Coskuner Ergul Belge Kurutas Filiz Hatipoglu Harun Ciralik Mehmet Sait Berhuni | 2014 | World Journal of Gastroenterology2014，20，12： | 9 |
| 4 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 5 | 温度、炭纤维和硅土粉对轻量混凝土力学性能的影响显示文摘研究了温度、炭纤维和硅土粉含量对轻量混凝土力学性能的影响。制备了含硅土粉(质量分数0%和10%)及炭纤维(质量分数0%,0.5%,1%,和2%)的混合物,测定了高温(400℃,600℃和800℃)暴烤后轻量混凝土的压缩强度和弯曲强度。采用三个控制因素(硅土粉含量、炭纤维含量及处理温度),应用Taguchi法确定最佳条件并减少实验次数,采用方差(Anova)法确定主要实验参数与轻量混凝土力学性能的基准。结果表明:轻量混凝土力学性能最实效的参数是加热程度,而抗拉强度与抗弯强度的最佳参数各不相同。 | Harun TANYILDIZI | 2008 | 新型炭材料2008，23，4： | 6 |
| 6 | The relationship between ischemic stroke and weather conditions in Duzce, Turkey显示文摘BACKGROUND: Weather conditions are thought to increase the risk of stroke occurrence. But their mechanism has not yet been clarified. We investigated possible relationships between ischemic stroke and weather conditions including atmospheric pressure, temperature, relative humidity, and wind speed.METHODS: One hundred and twenty-eight patients with ischemic stroke who had been admitted to our hospital between January 1 and December 31, 2010 were enrolled in this study. We investigated the relationship between daily cases and weather conditions the same day or 1, 2, and 3 days before stroke.RESULTS: A negative correlation was found between maximum wind speed and daily cases 3 days before stroke. As the relationship between daily cases and changes of weather conditions in consecutive days was evaluated, a negative correlation was found between daily cases and change of atmospheric pressure in the last 24 hours.CONCLUSIONS: The maximum wind speed 3 days before stroke and change of atmospheric pressure in the last 24 hours were found to increase the cases of ischemic stroke. We recommend that individuals at risk of ischemic stroke should pay more attention to preventive measures, especially on days with low maximum wind speed, on subsequent 3 days, and on days with low atmospheric pressure in the last 24 hours. | Harun Gunes Hayati Kandis Ayhan Saritas Suber Dikici Ramazan Buyukkaya | 2015 | World Journal of Emergency Medicine2015，6，3： | 6 |
| 7 | Phase recovery and holographic image reconstruction using deep learning in neural networks显示文摘Phase recovery from intensity-only measurements forms the heart of coherent imaging techniques and holography.In this study,we demonstrate that a neural network can learn to perform phase recovery and holographic image reconstruction after appropriate training.This deep learning-based approach provides an entirely new framework to conduct holographic imaging by rapidly eliminating twin-image and self-interference-related spatial artifacts.This neural network-based method is fast to compute and reconstructs phase and amplitude images of the objects using only one hologram,requiring fewer measurements in addition to being computationally faster.We validated this method by reconstructing the phase and amplitude images of various samples,including blood and Pap smears and tissue sections.These results highlight that challenging problems in imaging science can be overcome through machine learning,providing new avenues to design powerful computational imaging systems. | Yair Rivenson Yibo Zhang Harun Günaydın Da Teng Aydogan Ozcan | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 8 | Morphological and biochemical responses of Oryza sativa L.(cultivar MR219) to ion beam irradiation显示文摘Objective: Heavy ion beam, which has emerged as a new mutagen in the mutation breeding of crops and ornamental plants, is expected to result in the induction of novel mutations. This study investigates the morphological and biochemical responses of Oryza sativa toward different doses of carbon ion beam irradiation. Methods: In this study, the dry seeds of O. sativa were irradiated at 0, 20, 40, 60, 80, 100, and 120 Gy, followed by in-vitro germination under controlled conditions. Morphological and biochemical studies were conducted to investigate the morphological and physiological responses of O. sativa towards ion beam irradiation. Results: The study demonstrated that low doses(10 Gy) of ion beam have a stimulating effect on the height, root length, and fresh weight of the plantlets but not on the number of leaves. Meanwhile, doses higher than 10 Gy caused reductions in all the morphological parameters studied as compared to the control samples. The highest total soluble protein content [(2.11±0.47) mg/g FW] was observed in plantlets irradiated at 20 Gy. All irradiated plantlets were found to have 0.85% to 58.32% higher specific activity of peroxidase as compared to the control samples. The present study also revealed that low doses of ion beam(10 and 20 Gy) had negligible effect on the total chlorophyll content of O. sativa plantlets while 40 Gy had a stimulating effect on the chlorophyll content. Plantlets irradiated between 40 to 120 Gy were shown to be 0.38% to 9.98% higher in total soluble nitrogen content which, however, was not significantly different from the control samples. Conclusions: Carbon ion beam irradiation administered at low to moderate doses of 10 to 40 Gy may induce O. sativa mutants with superior characteristics. | Anna Pick Kiong LING Ying Chian UNG Sobri HUSSEIN Abdul Rahim HARUN Atsushi TANAKA Hase YOSHIHIRO | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，12： | 5 |
| 9 | SOME EULER SPACES OF DIFFERENCE SEQUENCES OF ORDER m显示文摘Kizmaz [13 ] 学习了差别顺序空格 ? ∞(Δ) , c (Δ) ,和 c0 (Δ) 。几篇文章处理了哪个被围住的 m-th 顺序差别的序列的集合,对零会聚,或会聚。Altay 和 Ba ? ar [5 ] 并且 Altay, Ba ? ar,和 Mursaleen [7 ] 介绍了 Euler 顺序空格 e (r) 0, e (r) c,和 e (r) ∞分别地。这篇文章的主要目的是介绍空格 e (r) 0 (Δ( m )), e (r) c (Δ( m )),并且 e (r)∞(Δ( m ))由其 m ( th )命令差别在 Euler 空格的所有序列组成 e (r) 0 , e (r) c ,和 e (r)∞分别地。而且,作者给一些拓扑的性质和包括关系,并且决定空格 e (r)的α-,β-,和γ- duals 0 (Δ( m )), e (r) c (Δ( m )),并且 e (r)∞(Δ( m )),并且空格 e (r)的 Schauder 基础 0 (Δ( m )), e (r) c (Δ( m ))。文章的最后节在顺序空间 e (r) c (Δ(m ) 上被奉献给一些矩阵地图砰的描述) 。给词调音:顺序 m 的差别顺序空格;Schauder 基础;α - ,β - ,和γ - duals; | Harun Polat Feyzi Basar | 2007 | Acta Mathematica Scientia2007，27，2： | 5 |
| 10 | Effects of vernal and allergic conjunctivitis on severity of keratoconus显示文摘AIM: To demonstrate the effects of two different types of allergic conjunctivitis on severity of keratoconus (KC). ·METHODS: We retrospectively reviewed the medical records of 171 KC patients referred between June 2010 and June 2011. The KC patients were divided into 3 groups as KC (group A), KC with vernal keratoconjunctivitis (VKC) (group B) and KC with allergic conjunctivitis (AC) (group C). Main outcome measures were demographic and ocular clinical features including age at presentation, gender, spherical equivalent (SE), best spectacle corrected visual acuity (BCVA), mean keratometric measurement (Km), central corneal thickness (CCT), and intraocular pressure (IOP). Groups were compared in term of study variables. · RESULTS: The median age at presentation was significantly lower in group B (P <0.001). According to the median SE (P =0.003), BCVA(P =0.022), Km(P <0.001), CCT (P =0.015) and Amsler-Krumeich classification (P < 0.001), KC was more severe in group B. There was no significant difference in terms of IOP and corrected IOP among the groups (P =0.44), however there were 4 patients who had increased corrected IOP developed after topical corticosteroid use in group B. The differences among the groups persisted even after controlling for age and gender. · CONCLUSION: Our findings demonstrated a more severe KC in VKC patients despite their younger age which suggests evaluation of VKC patients as a separate group in keratoconus disease. | Abdullah Kursat Cingu Yasin Cinar Fatih Mehmet Turkcu Alparslan Sahin Seyhmus Ari Harun Yuksel Muhammed Sahin Ihsan Caca | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 4 |
| 11 | Congenital H-type anovestibuler fistula显示文摘The congenital H-type fistula between the anorectum and genital tract besides a normal anus is a rare entity in the spectrum of anorectal anomalies. We described a girl with an anovestibuler H-type fistula and left vulvar abscess. A 40-day-old girl presented symptoms after her parents noted the presence of stool at the vestibulum. On the physical examination, anus was in normal location and size, and had normal sphincter tone. A vestibuler opening was seen in the midline just below of the hymen. A fistulous communication was found between the vestibuler opening and the anus, just above the dentate line. There was a vulvar abscess which had a left lateral vulvar drainage opening 15 mm left lateral to the perineum. After the management of local inflammation and abscess, the patient was operated for primary repair of the fistula. A protective colostomy wasn′t performed prior the operation. A profuse diarrhea started after 5 hours of postoperation. After the diarrhea, a recurrent fistula was occurred on the second postoperative day. A divided sigmoid colostomy was performed. 2 months later, and anterior sagital anorectoplasty was reconstructed and colostomy was closed 1 month later. Various surgical techniques with or without protective colostomy have been described for double termination repair. But there is no consensus regarding surgical management of double termination. | Mesut Yazlcl Barlas Etensel Harun Gürsoy Sezen zklsaclk | 2003 | World Journal of Gastroenterology2003，9，4： | 4 |
| 12 | Comparison of pre-treatment and post-treatment use of selenium in retinal ischemia reperfusion injury显示文摘AIM: To investigate the effects of selenium in rat retinal ischemia reperfusion(IR) model and compare pretreatment and post-treatment use.METHODS: Selenium pre-treatment group(n =8) was treated with intraperitoneal(i.p.) selenium 0.5 mg/kg for7 d and terminated 24 h after the IR injury. Selenium posttreatment group( n = 8) was treated with i. p. selenium0.5 mg/kg for 7d after the IR injury with termination at the end of the 7d period. Sham group(n =8) received i.p.saline injections identical to the selenium volume for 7d with termination 24 h after the IR injury. Control group(n =8) received no intervention. Main outcome measures were retina superoxide dismutase(SOD), glutathione(GSH),total antioxidant status(TAS), malondialdehyde(MDA),DNA fragmentation levels, and immunohistological apoptosis evaluation.RESULTS: Compared to the Sham group, selenium pre-treatment had a statistical difference in all parameters except SOD. Post-treatment selenium also resulted in statistical differences in all parameters except the MDA levels. When comparing selenium groups, the pre-treatment selenium group had a statistically higher success in reduction of markers of cell damage such as MDA and DNA fragmentation. In contrast, the post-selenium treatment group had resulted in statisticallyhigher levels of GSH. Histologically both selenium groups succeeded to limit retinal thickening and apoptosis. Pre-treatment use was statistically more successful in decreasing apoptosis in ganglion cell layer compared to post-treatment use.CONCLUSION: Selenium was successful in retinal protection in IR injuries. Pre-treatment efficacy was superior in terms of prevention of tissue damage and apoptosis. | Alper Yazici Hasan Aksit Esin Sogutlu Sari Arzu Yay Haydar Ali Erken Dilek Aksit Harun Cakmak Kamil Seyrek Sitki Samet Ermis | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 3 |
| 13 | Fabrication and characterization of affordable hydrophobic ceramic hollow fibre membrane for contacting processes显示文摘Affordable hydrophobic hollow fibre membranes were prepared using kaolin and alumina based ceramic powders via a combined phase inversion and sintering technique,followed by a grafting with fluoroalkylsilane(FAS).The crux of the matter in this paper is to study the changes in the properties of the hollow fibre membranes(gas permeation,mechanical strength,pore size,porosity,tortuosity,morphology,and contact angle)by the addition of alumina(Al2O3)to the pure kaolin with mono or multiparticle sizes.By varying the overall loading and particle size of alumina addition,different morphologies of the membranes were obtained due to the differences in the path lengths during phase inversion process for each solvent and nonsolvent exchange.The successful grafting with FAS was evidenced by the increase in contact angle from nearly equal to zero degree before grafting to 140°after grafting.Kaolin-alumina-4,one of the hollow fibres fabricated in this work,achieved a mean pore size of 0.25μm with the bending strength of 96.4 MPa and high nitrogen permeance of 2.3×10^(-5) mol·m^(-2)·Pa^(-1)·s^(-1),which makes the hollow fibre most suitable for the membrane contactor application. | Mohammed Abdulmunem ABDULHAMEED Mohd Hafiz Dzarfan OTHMAN Haider Nadhom Azziz Al JODA Ahmad Fauzi ISMAIL Takeshi MATSUURA Zawati HARUN Mukhlis A.RAHMAN Mohd Hafiz PUTEH Juhana JAAFAR | 2017 | Journal of Advanced Ceramics2017，6，4： | 3 |
| 14 | Multi-wavelength erbium-doped fiber laser using four-wave mixing effect in doped fiber显示文摘We demonstrate a multi-wavelength erbium-doped fiber laser (EDFL) using erbium gain and four-wave mixing (FWM) effect in a piece of erbium-doped fiber (EDF) with high erbium ion concentration. The EDF has a pump absorption rate of 24.6 dB/m at 979 nm and is bi-directionally pumped by 980-nm laser diodes. FWM effect redistributes the energy of different oscillating lines and causes multi-wavelength operation. The laser generates more than 22 lines of optical comb with a line spacing of approximately 0.10 nm at the 1569-nm region using only 1.5-m-long EDF. | N. S. Shahabuddin Z. Yusoff H. Ahmad S. W. Harun | 2011 | Chinese Optics Letters2011，9，6： | 3 |
| 15 | Q-switched pulse generation from an all-f iber distributed Bragg reflector laser using graphene as saturable absorber显示文摘A Q-switched distributed Bragg reflector fiber laser using a graphene passive saturable absorber is proposed in a cavity consisting of a fiber Bragg grating and Faraday rotator mirror as end mirrors, together with a highly doped erbium-doped fiber as a gain source. The laser has a Q-switched threshold of about 28 mW and a tunable repetition rate of 10.4-18.0 kHz with varying pump power. The shortest pulse width obtained from the system is 3.7 μs, with a maximum pulse energy and peak power of 22.2 nJ and 3.4 mW, respectively. | H. Ahmad F. D. Muhammad M. Z. Zulkifli S. W. Harun | 2013 | Chinese Optics Letters2013，11，7： | 3 |
| 16 | An artificial neural network approach for prediction of long-term strength properties of steel fiber reinforced concrete containing fly ash显示文摘In this study, an artificial neural network (ANN) model for studying the strength properties of steel fiber reinforced concrete (SFRC) containing fly ash was devised. The mixtures were prepared with 0 wt%, 15 wt%, and 30 wt% of fly ash, at 0 vol.%, 0.5 vol.%, 1.0 vol.% and 1.5 vol.% of fiber, respectively. After being cured under the standard conditions for 7, 28, 90 and 365 d, the specimens of each mixture were tested to determine the corresponding compressive and flexural strengths. The pa- rameters such as the amounts of cement, fly ash replacement, sand, gravel, steel fiber, and the age of samples were selected as input variables, while the compressive and flexural strengths of the concrete were chosen as the output variables. The back propagation learning algorithm with three different variants, namely the Levenberg-Marquardt (LM), scaled conjugate gradient (SCG) and Fletcher-Powell conjugate gradient (CGF) algorithms were used in the network so that the best approach can be found. The results obtained from the model and the experiments were compared, and it was found that the suitable algorithm is the LM algorithm. Furthermore, the analysis of variance (ANOVA) method was used to determine how importantly the experimental parameters affect the strength of these mixtures. | Okan KARAHAN Harun TANYILDIZI Cengiz D. ATIS | 2008 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2008，9，11： | 3 |
| 17 | L-carnitine alleviates sciatic nerve crush injury in rats:functional and electron microscopy assessments显示文摘Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus.It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats.Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes.After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days,axon area,myelin sheath area,axon diameter,myelin sheath diameter,and numerical density of the myelinated axons of injured sciatic nerve were similar to normal,and the function of injured sciatic nerve also improved significantly.These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats. | ümmü Zeynep Avsar Umit Avsar Ali Aydin Muhammed Yayla Berna Ozturkkaragoz Harun Un Murat Saritemur Tolga Mercantepe | 2014 | Neural Regeneration Research2014，9，10： | 3 |
| 18 | Dark pulse emission in nonlinear polarization rotation-based multiwavelength mode-locked erbium-doped fiber laser显示文摘We experimentally show dark pulse generation in all-normal dispersion multiwavelength erbium-doped fiber laser(EDFL) with a long cavity of figure-of-eight configuration. The EDFL generates a stable multiwavelength laser with 0.47 nm spacing at 24 m W threshold pump power, while the number of lines obtained increases with the pump power. A dark pulse emission is observed as the pump power is increased above 137 m W, with fundamental repetition rate of 29 k Hz and pulse width of 2.7 μs. It is observed that the dark pulse train can be shifted to second-, third-, and fourth-order harmonic dark pulses by carefully adjusting the polarization controller. For the fundamental dark pulse, the maximum pulse energy of 32.4 n J is obtained at pump power of 146.0 mW. | Zian Cheak Tiu Sin Jin Tan Harith Ahmad Sulaiman Wadi Harun | 2014 | Chinese Optics Letters2014，12，11： | 2 |
| 19 | Performance Evaluation of a Bilayer SPR-Based Fiber Optic RI Sensor With TiO2 Using FDTD Solutions显示文摘我们建议了新 bilayer 表面电浆子有银和 TiO 的 over-layer 的基于回声的光纤的折射索引传感器 < 潜水艇 class= “ a-plus-plus ” > 2 。我们数字地调查了 TiO 的最佳的厚度 < 潜水艇 class= “ a-plus-plus ” > 在建议传感器中的 2 over-layer 并且用有限差别的时间在水的媒介基于 silver-and-gold 的典型的二金属的层把它的性能比作那域途径。我们证明 TiO 的使用 < 潜水艇 class= “ a-plus-plus ” > 2 over-layer 极大地作为 over-layer 与黄金与那相比以敏感和 signal-to-noise 比率改进传感器表演。不仅做 TiO < 候补选手 class= “ a-plus-plus ” > 2 over-layer 提议为克服氧化的黄金的一种划算的选择问题,而且它允许回声 wavelength-tunability。 | Yusser AL-QAZWINI A. S. M. NOOR T. K. YADAV M. H. YAACOB S. W. HARUN M. A. MAHDI | 2014 | Photonic Sensors2014，4，4： | 2 |
| 20 | Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro显示文摘AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) cells.METHODS: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine stimulation.RESULTS: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic conditions.CONCLUSION: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and on the role of the CA9 gene as a positive disease regulator in human cancer. | Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said | 2012 | World Journal of Clinical Oncology2012，3，6： | 2 |
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