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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | The influence of proteins on demineralization kinetics of hydroxyapatite aggregates显示文摘 | Kosoric J Hector MP Anderson P | 2010 | J Bi- omed Mater Res A2010，94，3： | 1 |
| 3 | Mechanization process in the production of mescal 显示文摘 | Hector M Duran-Garcia Emilio J Gonzalez- Galv a n Pastor Matadamas-Ort i z | 2007 | Journal of Food Agriculture & Environment2007，5，34： | 1 |
| 4 | Apoptosis signaling proteins asprognostic biomarkers in colorectal cancer: a review 显示文摘 | HECTOR S PREHN J H | 2009 | Biochim Biophys Acta2009，1795，2： | 1 |
| 5 | METALLIC URETERAL STENTS FOR THE MANAGEMENT OF BENIGN UPPER URINARY TRACT OBSTRUCTION显示文摘 | Hector L Lopez-Huertas Anthony J Polcari Alex Acosta-Miranda Thomas M t Turk | 2009 | The Journal of Urology2009，，4： | 1 |
| 6 | The host response to sepsis and developmental impact显示文摘 | Wynn J Cornell T'F Hector R | 2010 | Pediatrics2010，125，5： | 1 |
| 7 | Infrared emission and ion-ion interactions in thulium- and terbium-doped gallium lanthanum sulphide glass 显示文摘 | SCHWEIZER T SAMSON B N HECTOR J R | 1999 | J Opt Soc Am B1999，16，2： | 1 |
| 8 | Infrared emission from holmium doped gallium lanthanum sulphide glass 显示文摘 | SCHWEIZER T SAMSON B N HECTOR J R | 1999 | Infr Plays Technol1999，40，： | 1 |
| 9 | Design and sensitivity analysis of dynamical systems subjected to stochastic loading 显示文摘 | Hector A J | 2005 | Computers and Structures2005，83，14： | 1 |
| 10 | Enhanced susceptibility to in vitro oxidation of the dense low-density lipoprotein subfraction in healthy subjects显示文摘 | Hak-Lemmers HL Hectors MP Demacker PN Hendriks JC Stalenhoef AF | 1991 | Arterioscler Thromb1991，11，2： | 1 |
| 11 | Multiparametric MP,1 a nalysis for the identification of high intensity focused ultrasound treated tumor tissue 显示文摘 | Hectors S J Jacobs I Strijkers G J | 2014 | PLoS One2014，9，99： | 1 |
| 12 | A one-parameter model for the soil water characteristic 显示文摘 | Gregson K Hector D J Mcgowan M | 1987 | European Journal of Soil Science1987，38，3： | 1 |
| 13 | An assessment of the current structure of food demand in urban China显示文摘 | Gould Brian W Villarreal Hector J | 2006 | Agricultural Economics2006，34，1： | 1 |
| 14 | Thermodynamic and Me- chanical Properties of Lanthanum-Magnesium Phases from Density Functional Theory 显示文摘 | Wrobel J Hector L G Wolf W | 2012 | J Alloys Compd2012，512，： | 1 |
| 15 | Molecular and morphological evidence for threespecies of Diplostomum ( Digenea : Diplostomidae) , parasites of fishes and fish-eat- ing birds in Spain显示文摘 | Perez-del-Olmo A Georgieva S Hector J P 2014 | 2014 | Parasites & Vectors2014，7，： | 1 |
| 16 | Planar coil- based differential electromagnetic sensor with null-offset 显示文摘 | ROBAINA R R HECTOR T A PLAZA J A | 2010 | Sensors and Actuators A2010，16，12： | 1 |
| 17 | Coupling protein stability and protein function in Escherichia coli CspA显示文摘 | Brian J Hillier Hector M Rodriguez Lydia M Gregoret | 1998 | Folding and Design1998，，2： | 1 |
| 18 | Ecosystem effects of hiodiversity manipulations in European grasslands显示文摘 | Spehn E M Hector A Joshi J | 2005 | Ecolog ical Monographs2005，75，1： | 1 |
| 19 | UAV attitude estimation using unscented Kalman filter and TR1 AD 显示文摘 | Hector Garcia de Marina Pereda F J Giron--Sierra J M | 2012 | IEEE Transactions on Industrial Electronics2012，59，11： | 1 |
| 20 | A one-parameter model for the soil water characteristic显示文摘 | Gregson K Hector D J McGowan M | 1987 | Journal of Soil Science1987，38，： | 1 |
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