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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 3 | Gynecologic oncologists involvement on ovarian cancer standard of care receipt and survival显示文摘AIM:To examine the influence of gynecologic oncolo-gists(GO) in the United States on surgical/chemotherapeutic standard of care(SOC), and how this translates into improved survival among women with ovarian cancer(OC).METHODS: Surveillance, Epidemiology, and End Result(SEER)-Medicare data were used to identify 11688 OC patients(1992-2006). Only Medicare recipients with an initial surgical procedure code(n = 6714) were included. Physician specialty was identified by linking SEER-Medicare to the American Medical Association Masterfile. SOC was defined by a panel of GOs. Multivariate logistic regression was used to determine predictors of receiving surgical/chemotherapeutic SOCand proportional hazards modeling to estimate the effect of SOC treatment and physician specialty on survival. RESULTS: About 34% received surgery from a GO and 25% received the overall SOC. One-third of women had a GO involved sometime during their care. Women receiving surgery from a GO vs non-GO had 2.35 times the odds of receiving the surgical SOC and 1.25 times the odds of receiving chemotherapeutic SOC(P < 0.01). Risk of mortality was greater among women not receiving surgical SOC compared to those who did [hazard ratio = 1.22(95%CI: 1.12-1.33), P < 0.01], and also was higher among women seen by non-GOs vs GOs(for surgical treatment) after adjusting for covariates. Median survival time was 14 mo longer for women receiving combined SOC. CONCLUSION: A survival advantage associated with receiving surgical SOC and overall treatment by a GO is supported. Persistent survival differences, particularly among those not receiving the SOC, require further investigation. | Sun Hee Rim Shawn Hirsch Cheryll C Thomas Wendy R Brewster Darryl Cooney Trevor D Thompson Sherri L Stewart | 2016 | World Journal of Obstetrics and Gynecology2016，5，2： | 3 |
| 4 | Performance evaluation of high modulus asphalt mixtures for long life asphalt pavements显示文摘 | Hynu J L Jung H L Hee M P | 2007 | Construction and Building Materials2007，21，5： | 1 |
| 5 | Biodegradation of low molecular weight organic acids in coniferous forest Podzolic soil显示文摘 | VAN HEES P A W JONES D L GODBOLD D L | 2002 | Soil Biology &Biochemistry2002，34，： | 1 |
| 6 | The carbon we do not see-the impact of low molecular weight compounds on carbon dynamics and respiration in forest soils: a review显示文摘 | VAN HEES P A W JONES D L FINLAY R | 2005 | Soil Biology : Biochemistry2005，37，1： | 1 |
| 7 | Distributioan of damaged ooaks and annual oak biomass removal by oak nut weevil ( Mechoris ursulus ) in Korea 显示文摘 | You H Y Young J C Hee S L | 2001 | Korean J Ecol2001，24，6： | 1 |
| 8 | eDNA cloning of a defender against apoptotic cell deathl ( DAD1 ) homologue,responsive to external tem- perature stimulus from the spider ,Aranenus ventricoctts 显示文摘 | Sik L K Hwa C E Hee H J | 2003 | Comp Biochem Physiol B Biochem Mol Bio12003，135，1： | 1 |
| 9 | Prebiotics and inulin-based fibers exert chronic effects on calcium utilization in a postmenopausal rodent model显示文摘 | Lee Cole L L Hee W L enhance magnesium absorption Berdine M R | 2012 | Journal of Food Science2012，77，4： | 1 |
| 10 | Measuring individual differences in Implicit cognition:The implicit association test显示文摘 | Greenwald A G McG hee D E Schwartz J L K | 1998 | Journal of Personality and Social Psychology1998，74，6： | 1 |
| 11 | 显示文摘 | Hee Y L Goodenough J B | 1999 | Journal of Solid State Chemistry1999，144，： | 1 |
| 12 | Hemolytic effects of dehydroepiandrosterone in vitro显示文摘 | Hu M L Hee Poh Ng Ming-Kuei Shih | 1997 | Life Science1997，61，21： | 1 |
| 13 | Performance evaluation of high modulus asphalt mixtures for long life asphalt pavements显示文摘 | Hynu J L Jung H L Hee M P | 2007 | Construction and building materials2007，21，5： | 1 |
| 14 | Gravity Survey of the North Sea 显示文摘 | Van Hees G L | 1983 | Marine Geodesy1983，6，2： | 1 |
| 15 | Thaumasite swelling in historic mortars: field observations and laboratory research显示文摘 | van HEES R P J WIJFFELS T J van der KLUGT L J A R | 2003 | Cem & Concr Compo2003，25，8： | 1 |
| 16 | Direct identification of Vibrio vulnificus in clinical specimens by nested PCR 显示文摘 | Hee E L Soo Y K Sei J K | 1998 | Journal of Clinical Microbiology1998，36，10： | 1 |
| 17 | Reconstruction of 3D human body pose from stereo image sequences based on top-down learning显示文摘 | Hee Deok Y Pseong Whan L | 2007 | Pattern Recognition2007，40，11： | 1 |
| 18 | Studies on the stubilitiesof red pepper oleoresin 显示文摘 | SOON K C HEE L G SENL B J | 1987 | Pharm Sci1987，16，3： | 1 |
| 19 | An overview of peak-to-averagepower ratio reduction techniques for multicarrier transmission 显示文摘 | Hee H S Hong L J | 2005 | IEEE Wireless Communications2005，12，2： | 1 |
| 20 | Design and practicalimplementation of multifrequency RF front ends using direct RF sampling 显示文摘 | Psiaki M L Powell S P Hee Jung | 2005 | IEEE Transactions on Microwave Theory and Techniques2005，53，10： | 1 |
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