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| 1 | Pancreatic cancer stem cell markers and exosomes-the incentive push显示文摘Pancreatic cancer(Pa Ca) has the highest death rate and incidence is increasing. Poor prognosis is due to late diagnosis and early metastatic spread, which is ascribed to a minor population of so called cancer stem cells(CSC) within the mass of the primary tumor. CSC are defined by biological features, which they share with adult stem cells like longevity, rare cell division, the capacity for self renewal, differentiation, drug resistance and the requirement for a niche. CSC can also be identified by sets of markers, which for pancreatic CSC(Pa-CSC) include CD44v6, c-Met, Tspan8, alpha6beta4, CXCR4, CD133, Ep CAM and claudin7. The functional relevance of CSC markers is still disputed. We hypothesize that Pa-CSC markers play a decisive role in tumor progression. This is fostered by the location in glycolipid-enriched membrane domains, which function as signaling platform and support connectivity of the individual Pa-CSC markers. Outsidein signaling supports apoptosis resistance, stem cell gene expression and tumor suppressor gene repression as well as mi RNA transcription and silencing. Pa-CSC markers also contribute to motility and invasiveness. By ligand binding host cells are triggered towards creating a milieu supporting Pa-CSC maintenance. Furthermore, CSC markers contribute to the generation, loading and delivery of exosomes, whereby CSC gain the capacity for a cell-cell contact independent crosstalk with the host and neighboring non-CSC. This allows PaCSC exosomes(TEX) to reprogram neighboring nonCSC towards epithelial mesenchymal transition and to stimulate host cells towards preparing a niche for metastasizing tumor cells. Finally, TEX communicate with the matrix to support tumor cell motility, invasion and homing. We will discuss the possibility that CSC markers are the initial trigger for these processes and what is the special contribution of CSC-TEX. | Sarah Heiler Zhe Wang Margot Zoller | 2016 | World Journal of Gastroenterology2016，22，26： | 8 |
| 2 | Comparison be- tween C band synthetic aperture radar and 3-D laser scanner statistics for the Baltic Sea ice 显示文摘 | SIMILA M MAKYNEN M HEILER I | 2010 | Journal of Geophysical Research2010，115，10： | 1 |
| 3 | An unsupervised change detec- tion and recognitionsystem for forestry 显示文摘 | HAME-T HEILER I SAN J | 1998 | International Journal of Remote Sensing1998，19，6： | 1 |
| 4 | Gender difference in analgesic response to the kappa-opioid pentazocine显示文摘 | Gear }{W Gordon NC Heiler PH | 1996 | Neurosci Lett1996，205，5： | 1 |
| 5 | Automatic land cover analysis for tenerife by supervised classification using remote sensed data显示文摘 | KEUCHEI J NAUMANN S HEILER M | 2003 | Remote Sensing of Environment2003，86，： | 1 |
| 6 | Semantic heterogeneity as a result of domain evaluation 显示文摘 | VENTRONE V HEILER S | 1991 | Semantic Issues in Multidatabase Systems1991，20，4： | 1 |
| 7 | A Deterministic Queueing Model 显示文摘 | MAY A D HEILER H E M | 1967 | Transportation Research1967，1，2： | 1 |
| 8 | An unsupervised change detection and recognition system for forestry显示文摘 | Hame T Heiler I Jesus S M A | 1998 | International Journal of Remote Sensing1998，19，6： | 1 |
| 9 | Femoral neck cut level af- fects positioning of modular short - stem implant 显示文摘 | Mihalko WM Saleh KJ HeIler MO | 2009 | Orthopedics2009，10，： | 1 |
| 10 | Learning sparse representations by non-negative matrix factorization and sequential cone programming显示文摘 | HEILER M SCHN R R C | 2006 | The Journal of Machine Learning Research2006，，7： | 1 |
| 11 | Quantitative instrumental and sensory studies on aroma compounds contributing to a metallic flavour defect in buttermilk 显示文摘 | Heiler C Schieberle P | 1997 | Int Dairy J1997，，7： | 1 |
| 12 | An Unsuper vised Change and Recognition System for Forestry 显示文摘 | HAME T HEILER I MIGUEDAYANZ J S | 1998 | International Journal of Remote Sensing1998，19，6： | 1 |
| 13 | Adapting to C hmate Change 显示文摘 | HeIler Peter Mani M | 2002 | Finance and Development2002，，39： | 1 |
| 14 | Homogeneous/ heterogeneous condensation in transonic nozzle flows显示文摘 | Heiler M Winkler G Schnerr G H | 2000 | Zeitschrift fur Angewandte Mathematik und Mechanik2000，80，3： | 1 |
| 15 | An unsupervised change detection and recognition system for forestry 显示文摘 | Hame T Heiler I Ayanz J S M | 1998 | IEEE Transactions on Geoscience and Remote Sensing1998，36，19： | 1 |
| 16 | Automatic Land Cover Analysis for Tenerife by Supervised Classification Using Remotely Sensed Data显示文摘 | Keuchel J Naumann S Heiler M | 2003 | Re- mote Sensing of Environment2003，86，4： | 1 |
| 17 | Repository Support for Metadata-based Legacy Migration显示文摘 | Heiler S Lee W C Mitchell G | 1999 | IEEE Data Engineer Bulletin1999，22，1： | 1 |
| 18 | Preventing sharps injuries in the operating room 显示文摘 | Berguer R Heiler PJ | 2004 | J Am Coll Surg2004，，： | 1 |
| 19 | Semantic heterogeneity as a result of domain evaluation显示文摘 | Ventrone V Heiler S | 1991 | Sheth: Semantic Issues in Multidatabase Systems1991，20，4： | 1 |
| 20 | Automatic Land Cover Analysis for Tencrife by Supervised Classification Using Remotely Sensed Data显示文摘 | Keuchel J Naumann S Heiler M | 2003 | Remote Sensing of Environment2003，86，4： | 1 |
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