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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | An abattoir survey of tuberculosis in feral buffaloe 显示文摘 | Hein W R Tomasovic A A | 1981 | Australian Veterinary Journal1981，57，12： | 1 |
| 3 | Cue reactivity and effects of exposure in abstinent posttreatment drug users显示文摘 | Ingmar HA Hein A Chris W | 1999 | J Subst Abuse Treat1999，16，： | 1 |
| 4 | Magnesium: material future显示文摘 | Heine with a H J | 1999 | Foundry Material and Technology1999，，6： | 1 |
| 5 | Recombinant fowlpox virus vaccines against Australian virulent Marek's disease virus: gene sequence analysis and comparison of vaccine efficacy in specific pathogen free and production chickens 显示文摘 | Heine H G Foord A J Peter L | 1997 | Virus Res1997，50，： | 1 |
| 6 | Distribution, Aggregate De- mand and Productivity Growth: Theory and Empiri- cal Results for Six OECD Countries Based on a Post- Kaleckian Model显示文摘 | Hein E Tarassow A | 2010 | Cambridge Journal of Econom- ics2010，34，4： | 1 |
| 7 | Global occurrence of Tellurium-rich ferromanganese crusts and a model for the enrichment of tellurium显示文摘 | Hein J R Koschinsky A Halliday A N | | 0，，： | 1 |
| 8 | Fluid inclusion petrogra-phy 显示文摘 | VAN DEN K A M HEIN U F | 2001 | Lithos2001，55，1： | 1 |
| 9 | Functional disturbances due to structural remodeling in the failing human heart显示文摘 | Hein SElsasser A Kostin S | 2002 | Arch Mal Coeur Vaiss2002，95，9： | 1 |
| 10 | Molecular genetics and epidemiology of NAT1 and NAT2 acetylating polymorphisms显示文摘 | Hein DW Doll MA Fret Land A J | 2000 | Cancer Epidemiol Biomarkers Prev2000，9，： | 1 |
| 11 | A capripoxvirus detection PCR and antibody ELISA based on the maior antigen P32, the homolog of the vaccinia virus H3L gene 显示文摘 | Heine H G Stevens M P Foord A J | 1999 | J Immune Meth1999，277，： | 1 |
| 12 | Mechanisms of energy absorption in special devices for use in earthquake resistant structures显示文摘 | Kelly J M Skinner R I Heine A J | 1972 | Bulletin of New Zealand National Society for Earthquake Engineering1972，5，3： | 1 |
| 13 | Branch characteristics of widely spaced Douglas fir in south-westeru Germany: comparisons of modelling approaches and geographic regions 显示文摘 | Hein S Weiskittel A R Kohnle U | 2008 | Forest Ecology and Management2008，256，5： | 1 |
| 14 | Polydispersity of primary particles in agglomerates made by coagulation and sintering显示文摘 | Martin C H Heine A Sotiris E | 2007 | Aerosol Science2007，38，1： | 1 |
| 15 | Genetic variants of IL-13 signalling and human asthma and atorpy显示文摘 | Hein Z mann A Mao XQ Akainua M | 2000 | Hum Mol Genet2000，9，： | 1 |
| 16 | Production of poly(4-hydroxybutyric acid) by fed-batch cultures of reecombinant strains of Escherichia coli显示文摘 | Song S Hein S Steinb chel A | 1999 | Biotechnol Lett1999，21，： | 1 |
| 17 | Global occurrence of Tellurium-rich ferromanganese crusts and a model for the enrichment of Tellurium显示文摘 | HEIN J R KOSCHINSKY A HALLIDAY A | 2003 | Geochimica et Cosmochimica Acta2003，67，6： | 1 |
| 18 | Neutrophil granule products:can they identify subclinical chorioamnionitis in patients with preterm premature rupture of membranes显示文摘 | Grable I A Heine R P | | 0，，03： | 1 |
| 19 | Influence of quantum confinement on the electronic structure of the transition metal sulfide TS2显示文摘 | Kuc A Zibouche N Heine T | | 0，，： | 1 |
| 20 | Renal handling of u-rate and sodium during acute physiological hyperinsulinaemia inhealthy subjects显示文摘 | Ter Maaten JC Voorburg A Heine RJ | 1997 | Clin Sci (Lond) ?1997，92，1： | 1 |
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