|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 2 | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum loeosporioides, causal agent of anthracnose disease in tropical fruits 显示文摘 | Almada Ruiz E Martinez Tellez M A Hem ndez Alamos M M | 2003 | Pest Manag Sci2003，59，： | 1 |
| 3 | ,Temporal and Spatial Variability in the Estrogenicity of a Municipal Wastewater Effluent显示文摘 | Hemming J M Allen H J Thuesen K A | 2004 | Ecotoxicology and Environmental Safety2004，57，： | 1 |
| 4 | Fine mapping of the tomato I-3 gene for fusarium wilt resistance and elimination of a co-segregating resistance gene analogue as a candidate for I- 3显示文摘 | HEMMING M N BASUKI S MCGRAIH D J | 2004 | Theor Appl Genet2004，109，： | 1 |
| 5 | Geochemicalapproaches to sedimentation, provenance, and tectonics显示文摘 | McLennan S M Hemming S McDaniel D K | 1993 | Geological Society of America Special Papers1993，284，： | 1 |
| 6 | Evidence of extensive interspecies transfer of integron-mediated antimicro- bial resistance genes among multidrug-resistant Entero bacteria- ceae in a clinical setting 显示文摘 | Leverstein-van Hall M A Box ATA Blok HEM | 2002 | J Infect Dis2002，186，： | 1 |
| 7 | Early Protemzoie Crustal Evolution: Geochemical And Nd-Pb Isotopic Evidence From Metasedimentary Rocks, Southwestern North America 显示文摘 | Mclennan S M Hemming S R Taylor S R Eriksson K A | 1995 | Geochim Cosmochim Acta1995，59，6： | 1 |
| 8 | Emerging role of neuronal exosomes in the central nervous system显示文摘 | Chivet M Hemming F Pernet-Gallay K | 2012 | Front Physiol2012，3145，： | 1 |
| 9 | Short-term effects of salt stress on antioxidant system and leaf water relations of Pea leaves 显示文摘 | Hem'andez J A Almansa M S | 2002 | Physiol Plant2002，115，： | 1 |
| 10 | Improved accessibility and re- activity of dissolving pulp for the viscose process: pretreatment with monocomponent endoglucanase 显示文摘 | Engstrfim A C Ek M Hem'ikssan G | 2006 | Biomacromolecules2006，7，6： | 1 |
| 11 | Structure, regulation and function of PKB/AKT - a major therapeutic target显示文摘 | Hanada M Feng J Hemmings BA | 2004 | Biochem Biophys Acta2004，1697，12： | 1 |
| 12 | Antimicrobial activity of polysaccharide films containing essential oils显示文摘 | Sanchez-González L Cháler M Hemández M | | 0，，08： | 1 |
| 13 | Production ofgriseofulvin by Khuskia oryzae 显示文摘 | Broadbent D Hemming HG Lehan M | 1974 | Transactions of ihe BritishMycological Society1974，62，3： | 1 |
| 14 | Geochemical approaches to sedimentation, provenance, and tcctonics显示文摘 | Mclennan S M Hemming S McDanial D K | 1993 | Geological Society of American Special Paper1993，284，： | 1 |
| 15 | Structure, regulation and func- tion of PKB/AKT-a major therapeutic target 显示文摘 | Hanada M Feng J Hemmings B A | 2004 | Biochem Biophys Acta2004，1697，12： | 1 |
| 16 | Exopolysaccharides produced by intestinal Bifidobacteriurn strains act as fermentable substrates for human intestinal bac- teria显示文摘 | Salazar N Gueimonde M Hem Ndez-Barranco AM | 2008 | Appl & Environ Microbiol2008，74，15： | 1 |
| 17 | Geochemical approaches to sedimentation, provenance, and tectonics显示文摘 | McLennan S M Hemming S McDanial D K | 1993 | Geologi- cal Society of American Special Paper1993，284，： | 1 |
| 18 | Investigating the role of the brain-derived neurotrophic factor (BDNF) va166met variant in obsessive-compulsive disorder (OCD) 显示文摘 | HEMMINGS S M KINNEAR C J van der MERWE L et al | 2008 | World J Biol Psychiatry2008，9，2： | 1 |
| 19 | Structure, regulation and function of PKB/AKT-a major therapeutic target 显示文摘 | Hanada M Feng J Hemmings BA | 2004 | Biochim Biophys Acta2004，1697，12： | 1 |
| 20 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员