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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Treatment of Budd-Chiari syndrome with a focus on transjugular intrahepatic portosystemic shunt显示文摘AIM:To evaluate long-term complications and survival in patients with Budd-Chiari syndrome (BCS) referred to a Danish transjugular intrahepatic portosystemic shunt (TIPS) centre.METHODS:Twenty-one consecutive patients from 1997-2008 were retrospectively included [15 women and 6 men,median age 40 years (range 17-66 years)].Eighteen Danish patients came from the 1.8 million catchment population of Aarhus University Hospital and three patients were referred from Scandinavian hospitals.Management consisted of tests for underlying haematological,endocrinological,or hypercoagulative disorders parallel to initiation of specific treatment of BCS.RESULTS:BCS was mainly caused by thrombophilic (33%) or myeloproliferative (19%) disorders.Fortythree percents had symptoms for less than one week with ascites as the most prevalent finding.Fourteen (67%) were treated with TIPS and 7 (33%) were manageable with treatment of the underlying condition and diuretics.The median follow-up time for the TIPS-treated patients was 50 mo (range 15-117 mo),and none required subsequent liver transplantation.Ascites control was achieved in all TIPS patients with a marked reduction in the dose of diuretics.A total of 14 TIPS revisions were needed,mostly of uncovered stents.Two died during follow-up:One non-TIPS patient worsened after 6 mo and died in relation to transplantation,and one TIPS patient died 4 years after the TIPS-procedure,unrelated to BCS.CONCLUSION:In our BCS cohort TIPS-treated patients have near-complete survival,reduced need for diuretics and compared to historical data a reduced need for liver transplantation. | Anders Bay Neumann Stine Degn Andersen Dennis Tφnner Nielsen Peter Holland-Fischer Hendrik Vilstrup Henning Grφnbk | 2013 | World Journal of Hepatology2013，5，1： | 5 |
| 3 | Integrity of complex shape product by powder injection molding 显示文摘 | HENS K F LEE D LIN S T | 1991 | Powder Metallurgy International1991，23，1： | 1 |
| 4 | Total domination subdivision numbers of trees显示文摘 | Haynes T W Henning M A Hopkins L | 2004 | Discrete Mathematics2004，286，： | 1 |
| 5 | Mechanisms of the inhibitory effect of the cyanobacterium Microcystis aeruginosa on Daphnia galeata's ingestion rate 显示文摘 | Rohrlack T Henning M Kohl J G | 1999 | J Plankt Res1999，21，： | 1 |
| 6 | Does prospect theory explain the disposition effect显示文摘 | Hens T Vlcek M | 2011 | Journal of Behavioral Finance2011，12，3： | 1 |
| 7 | Labeling human embryonic stem-cell-derived car- diomyocytes for tracking with MR imaging 显示文摘 | CASTANEDA R T BODDINGTON S HENNING T D | 2011 | Pediatric radiology2011，41，11： | 1 |
| 8 | Urea for preservation of moist hay显示文摘 | Henning J C Dougherty C T Leary J | 1990 | Anim Feed Sci Technol1990，31，34： | 1 |
| 9 | Nanodiamond bioconjugate probes and their collection by electrophoresis 显示文摘 | Hens S C Cunningham G Tyler T | 2008 | Diamond Relat Mater2008，17，11： | 1 |
| 10 | Waste management options to reduce greenhouse gas emissions from paper in Australia 显示文摘 | Pickin J G Yuen S T S Hennings H | 2002 | Atmospheric Environment2002，36，4： | 1 |
| 11 | Ontogenic regulation of components of ileal bile acid absorption显示文摘 | Hwangs T Henning SJ | 2001 | Exp Biol Med2001，226，7： | 1 |
| 12 | Total Domination Critical and Stable Graphs upon Edge Removal 显示文摘 | DESORMEAUX W J HAYNES T W HENNING M A | 2010 | Discrete Applied Mathematics2010，158，： | 1 |
| 13 | Res-veratrol, acomponent of red wine,elicits dilation of iso-lated porcine retinal arterioles role of nitric oxide andpotassium channels 显示文摘 | NAGAOKA T HEN T W YOSHIDA A | 2007 | Investigative OphthalmologyVisual Science2007，48，9： | 1 |
| 14 | Advances in the Science and Technology of Carbon Nanotubes and Their Composites: A Heview显示文摘 | Thostenson E T Hen Z Chou T W | 2001 | Composites Science and Technology2001，61，13： | 1 |
| 15 | Na + , K - AT- Pase as a docking station: protein-protein complexes of the Na + , K - ATPase 显示文摘 | LINDA R HENNING T MICHAEL J C | 2013 | Cell Mol Life Sci2013，70，： | 1 |
| 16 | AntilFe epsilon RI alphaserum autoantibodies in different subtypes of urticaria显示文摘 | Zuberbier T Hens BM Fiebiger E | 2000 | Allergy2000，55，： | 1 |
| 17 | Variability,Reproducibility and Application of precordial ST-segment mapping following acute myocardial infarction显示文摘 | Hardarson T Henning H Robert A | 1978 | Circulation1978，57，6： | 1 |
| 18 | E strogen selectively up regulates eNOS and nNOS in reproductive arteries by transcrip-tional mechanisms显示文摘 | Rosen feld C R C hen C Roy T | 2003 | J Soc Gyneco Ⅰ Invest2003，10，4： | 1 |
| 19 | Diabetesinduced myocardial structural changes: Rote of endothelin-1 and its receptors显示文摘 | ( hen S Evans T Mukheriee K | 2000 | Mol Cell Cardiol2000，32，9： | 1 |
| 20 | Detecting Flushing of Thin Sprayed Seal Pavements Using Pavement Management Data显示文摘 | Kodippily S Henning T Ingham J M | 2012 | Journal of Transportation Engineering2012，138，5： | 1 |
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