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| 1 | 血栓性血小板减少性紫癜患者vWF裂解蛋白酶抗原和活性的检测及意义显示文摘目的研究血管性血友病因子裂解蛋白酶(ADAMTS13)抗原含量和活性在血栓性血小板减少性紫癜(TTP)患者及遗传性 TTP 家族突变携带者中变化的情况。方法用残余胶原结合实验(RCBA)检测13例 TTP 患者共28份血浆标本[含血浆置换(PE)前后]及10例携带者的 ADAMTS13活性;用新近建立的三抗体夹心酶联免疫反应法检测标本的 ADAMTS13抗原含量。结果正常对照组 ADAMTS13含量为(600.93±145.36)mU/ml(设白种人混合血浆的 ADAMTS13抗原含量为1000mU/ml),活性为(74.79±11.81)%。遗传性 TTP 患者 ADAMTS13抗原含量和活性治疗前和发病间期均明显减低,PE 后恢复;其家族中携带者 ADAMTS13抗原含量为(331.40±109.85)mU/ml,活性为(66.79±12.82)%(与对照组比较,P 值分别<0.01和>0.05);原发性 TTP 患者 PE 前 ADAMTS13抗原含量为(98.7±82.08)mU/ml,活性为(22.23±19.07)%(与对照组比较,P 值均<0.01);PE 后ADAMTS13 抗原含量为(449.4±232.33)mU/ml,活性为(60.92±22.33)%(与对照组比较,P 值分别<0.01和>0.05);1例继发性 TTP 患者 PE 后 ADAMTS13抗原含量远高于正常,活性仅为6.00%结论治疗前的 TTP 患者 ADAMTS13抗原含量和活性均明显减低。大多数患者两指标变化趋势一致,也有个别患者两指标变化趋势相反,前者可能因为遗传因素或体内免疫系统的廓清作用,后者可能因为抗 ADAMTS13抗体仅抑制了 ADAMTS13的活性而未影响其抗原的含量或其他未知原因所致。 | 刘芳 BF Hendrik 董宁征 白霞 V Karen D Hans 阮长耿 | 2006 | 中华血液学杂志2006，27，3： | 10 |
| 2 | Localization and reactivity of an immunodominant domain in the NS3 region of hepatitis C virus 显示文摘 | Hendrik C André V Wilfried M | 1995 | Med Virol1995，45，： | 2 |
| 3 | Environmentally acceptable specialty lubricantsan interpretation of the environmental regulations of North Sea(world)显示文摘 | Stringfellow W D Jacobs N L Hendriks R V | 1993 | NLGI Spokesman1993，57，9： | 1 |
| 4 | Accumlation of organochlorines and brominated flame retardants in estuarine and marine food chains:Field measurements and model calculations显示文摘 | VELTMAN K HENDRIKS J HUIJBREGTS M LEONARDS P HEUVEL-GREVE M V D VETHAAK D | 2005 | Mar Pollut Bull2005，50，10： | 1 |
| 5 | A Gravity Model of hnmigration 显示文摘 | Joshua J L Hendrik V B | 2008 | Economics Letters2008，99，1： | 1 |
| 6 | Root responses to nutrients and soil biota: drivers of species coexistence and ecosystem productivity显示文摘 | Kroon H D Hendriks M Ruijven J V | 2012 | Journal of Ecology2012，100，1： | 1 |
| 7 | Effects of sex and dietary phosphorus level on the apparent metabolizable energy and nutrition digestibility in broiler thickens 显示文摘 | Ravindran V Wu Y B Hendriks W H | 2004 | Archives of Animal Nutrition2004，58，5： | 1 |
| 8 | A prospective,randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma显示文摘 | Hendrik V P Luigi D P Walter A | 2011 | European Urology2011，59，4： | 1 |
| 9 | Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects 显示文摘 | HENDRIKS H F WESTSTRATE J A VLIET T V | 1999 | Eur J Clin Nutr1999，53，4： | 1 |
| 10 | TheβA 4 amyloid precursor protein gene and Alzheimer's disease显示文摘 | Hendriks L Broeckhoven C V | 1996 | Eur J Biochem1996，237，： | 1 |
| 11 | Three-dimen- sional Numerical Simulation of Flow and Heat Trans- fer in the Sulzer SMX Satic Mixer显示文摘 | Jildert E V Peter F R Hendrik W H | 1999 | Chemical Engi- neering Science1999，，54： | 1 |
| 12 | Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesetrolemic and nfildly hypercholesterolernic subjects显示文摘 | Hendriks H F N Weststrate J A Van V T | 1999 | European Journal of Clinical Nutrition1999，53，： | 1 |
| 13 | Different mechanisms contribute to the biphasic pattern of carboxypeptidase U (TAFIa) generation during in vitro clot lysis in human plasma显示文摘 | Leurs J Nerme V Hendriks D | 2003 | Thromb naemost2003，89，2： | 1 |
| 14 | Reference architecture for holonic manufacturing systems: PROSA 显示文摘 | Hendrik V B | 1998 | Computers in Industry1998，37，3： | 1 |
| 15 | Effects of microbial phytase produced by solid-state fermentation on the performance and nutrient utilization of broilers fed maize- and wheat- based diets显示文摘 | Wu Y B Ravindran V Hendriks W H | 2003 | Br Poult Sci2003，44，： | 1 |
| 16 | Active contril of slow light on a chip with photonic crystal waveguides显示文摘 | Yudi A V Martin O B Hendrik E H | 2005 | Nature2005，438，： | 1 |
| 17 | Reference architecture for Holonic manufacturing systems:PROSA显示文摘 | HENDRIK V B JO W PAUL V | 1998 | Computers in Industry1998，37，3： | 1 |
| 18 | Multicomponent phase equilibrium calculations for water-methanol-alkane mixtures显示文摘 | Kontogeorgis G M Yakoumis I V Meijer H Hendriks E Moorwood T | 1999 | Fluid Phase Equilibria1999，160，： | 1 |
| 19 | PDZ domains glue and guide 显示文摘 | Ham M V Hendriks W | 2003 | Mol Biol Rep2003，30，2： | 1 |
| 20 | Short-range control of cell differentiation in the Arabidopsis root meristem显示文摘 | VAN DEN BERG C WILLEMSEN V HENDRIKS G | 1997 | Nature1997，390，6657： | 1 |
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