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| 1 | MicroRNA-135a Modulates Hepatitis C Virus Genome Replication through Downregulation of Host Antiviral Factors显示文摘Cellular microRNAs(miRNAs) have been shown to modulate HCV infection via directly acting on the viral genome or indirectly through targeting the virus-associated host factors. Recently we generated a comprehensive map of HCV–miRNA interactions through genome-wide miRNA functional screens and transcriptomics analyses. Many previously unappreciated cellular miRNAs were identified to be involved in HCV infection, including miR-135a, a human cancerrelated miRNA. In the present study, we investigated the role of miR-135a in regulating HCV life cycle and showed that it preferentially enhances viral genome replication. Bioinformatics-based integrative analyses and subsequent functional assays revealed three antiviral host factors, including receptor interacting serine/threonine kinase 2(RIPK2), myeloid differentiation primary response 88(MYD88), and C-X-C motif chemokine ligand 12(CXCL12), as bona fide targets of miR-135a. These genes have been shown to inhibit HCV infection at the RNA replication stage. Our data demonstrated that repression of key host restriction factors mediated the proviral effect of miR-135a on HCV propagation. In addition,miR-135a hepatic abundance is upregulated by HCV infection in both cultured hepatocytes and human liver, likely mediating a more favorable environment for viral replication and possibly contributing to HCV-induced liver malignancy.These results provide novel insights into HCV–host interactions and unveil molecular pathways linking miRNA biology to HCV pathogenesis. | Catherine Sodroski Brianna Lowey Laura Hertz T.Jake Liang Qisheng Li | 2019 | Virologica Sinica2019，34，2： | 5 |
| 2 | SoxC transcription factors in retinal development and regeneration显示文摘Glaucoma and other optic neuropathies result in optic nerve degeneration and the loss of retinal ganglion cells(RGCs)through complex signaling pathways.Although the mechanisms that regulate RGC development remain unclear,uncovering novel developmental pathways may support new strategies to regenerate the optic nerve or replace RGCs.Here we review recent studies that provide strong evidence that the Sry-related high-mobility-group C(SoxC)subfamily of transcription factors(TFs)are necessary and sufficient for axon guidance and RGC fate specification.These findings also uncover novel SoxC-dependent mechanisms that serve as master regulators during important steps of RGC development.For example,we review work showing that SoxC TFs regulate RGC axon guidance and direction through the optic chiasm towards their appropriate targets in the brain.We also review work demonstrating that Sox11 subcellular localization is,in part,controlled through small ubiquitin-like post-translational modifier(SUMO)and suggest compensatory cross-talk between Sox4 and Sox11.Furthermore,Sox4 overexpression is shown to positively drive RGC differentiation in human induced pluripotent stem cells(hi PSCs).Finally,we discuss how these findings may contribute to the advancement of regenerative and cell-based therapies to treat glaucoma and other optic nerve neuropathies. | Kun-Che Chang Jonathan Hertz | 2017 | Neural Regeneration Research2017，12，7： | 3 |
| 3 | LGMD2I是Duchenne型或Becker型肌营养不良的特征性表型 | Schwartz M. Hertz J.M. Sveen M.L. Vissing J. 谢琰臣 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，9： | 3 |
| 4 | A tabu search heuristic for the capacitated arc routing prohlem显示文摘 | Hertz A Laporte G Mittaz M | 2000 | Operations Research2000，48，1： | 1 |
| 5 | The registry of the international society for heart and lung transplantation:nineteenth official report-2002显示文摘 | Hertz MI Taylor DO Tndock EP | 2002 | J Heart-Lung Transplantation2002，21，9： | 1 |
| 6 | On the contact of elastic solids 显示文摘 | HERTZ H | | J Reine Angew Math0，92，15： | 1 |
| 7 | Prophylactic antibiotics prior to bacteremia decrease endovascular graft infection in dogs显示文摘 | Kirksey L Brener BJ Hertz S | 2002 | Vase Endovascular Surg2002，36，3： | 1 |
| 8 | The registry of the International Society for Heart and Lung Transplantation: introduction to the Twentieth Annual Reports-2003 显示文摘 | Hertz MI Mohacsi PJ Taylor DO | 2003 | J Heart Lung Transplant2003，22，6： | 1 |
| 9 | Measurement of high order Kerr refractive index of major air components显示文摘 | Loriot V Hertz E Faucher O | 2009 | Optics Express2009，17，13： | 1 |
| 10 | On the equilibrium of floating elastic plates显示文摘 | HERTZ H | | Ann Phys Chem0，22，： | 1 |
| 11 | Uber die Beruhrung fester elastischer Korper 显示文摘 | HERTZ H | | Journal fur die Reine und Angewandte Mathematik0，92，4： | 1 |
| 12 | Debris elimination in a droplet-target laser-plasma soft X-ray source显示文摘 | Hertz H M | 1995 | Review of Scientific Instruments1995，66，： | 1 |
| 13 | Growth hormone and insulin-like growth factor I increase macrophage uptake and begradation of low-density lipoprotein显示文摘 | Hochberg Z Hertz P Maor G | 1992 | Endocrinol1992，131，： | 1 |
| 14 | Small bowel obstruction secondary to Crohn's disease: CT findings显示文摘 | Zissin R Hertz M Paran H | 2004 | Abdom Imaging2004，29，： | 1 |
| 15 | A tabu search heuristic forthe capacitated arc routing problem 显示文摘 | HERTZ A LAPORTE G MHTAZ M | 2000 | Operations Research2000，28，1： | 1 |
| 16 | Complete amino acid sequence of the human alpha 5 (IV) collagen chain and identification of a single-base mutation in exon 23 converting glycine 521 in the collageuous domain to cysteine in an Alport syndrome patient显示文摘 | ZHOU J HERTZ J M LEINONEN A | 1992 | The Journal of Biological Chemistry1992，267，12： | 1 |
| 17 | A tunable synthetic hydrogel system for culture of retinal ganglion cells and amacrine cells显示文摘 | Hertz J Robinson R Valenzuela DA | 2013 | Acta Biomaterialia2013，9，8： | 1 |
| 18 | Aprospective study of dietaryintakeandacquiredimmunedeficiencysyndromeinHIV - seropositiveho -mosexualmen显示文摘 | Abrams B Duncan D Hertz - Picciottal | 1993 | JAcquir DeficSyndr1993，6，： | 1 |
| 19 | Reproduction of the obliterative bronchiolitis lesion after heterotopic transplantation of mouse airways 显示文摘 | Hertz M I Jessurun J King M B | 1993 | AmJPathol1993，142，6： | 1 |
| 20 | Growth hormone and insulin-like growth factor I increase macrophage uptake and degradation of low-density lipoprotein显示文摘 | Hochberg Z Hertz P Maor G | 1992 | Endocrinology1992，131，1： | 1 |
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