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| 1 | Changes in myocardial collagen content before and after left ventricular assist device application in dilated cardiomyopathy显示文摘Background The purposes of this study were to confirm the changes in myocardial collagen level after left ventricular assist device (LVAD) support in dilated cardiomyopathy (DCM), find the relation between these changes and prognosis, an d test a practical method to assess the level of myocardial collagen.Methods Left ventricular samples were collected from DCM patients with different prognosis (transplanted group n=8, weaning group n=10) at the time when the LV ADs were implanted and again during cardiac transplantation (n=8). The level of neutral salt soluble collagen (NSC) and acid soluble collagen (ASC) was measured by Sircol collagen assay, and that of total collagen and insoluble collagen (ISC) by quantification of hydroxyproline (Hyp). Serum samples were collected from a portion of these patients (transplanted group, n=6; weaning group n=7) at the time the LVADs were implanted, 1 month after implantation and on explantation. Circulating concentration of carboxy-terminal propeptide of type Ⅰ procollagen (PⅠCP), amino-terminal propeptide of type Ⅰ procollagen (PⅠNP), amino-terminal propeptide of type Ⅲ procollagen (PⅢNP) and type Ⅰ collagen telopeptide (ⅠCTP) were measured by the equilibrium type radioimmunoassay. Results Before LVAD implantation the level of NSC and ISC in th e weaning group was higher but ASC in the transplanted group was lower than in the control s (P<0.05). After LVAD support, the level of total collagen was higher, but ASC was also lower in the transplanted group than in the controls (P<0.05). In comparison of the pre- and po st-LVAD subgroups of the transplanted and weaning groups, all collagen fraction levels before LVAD implantation were lower in the transplanted group than in the weaning group (P<0.05); but this difference disappeared after LVAD support. Comparison of the pre- and post-LVAD subgroups of the transplanted group showed increased le vel of NSC and total collagen after LVAD support. The changes of serum p eptide concentration showed that PⅢNP increased constantly in the transplanted group, but PⅠCP and PⅠNP increased in the weaning group after LVAD implantation. Conclusions The changes in myocardial collagen level as a sign of myocardial interstitial remodeling in DCM are not involved with total collagen b ut invalved with collagen fractions, and they are related to prognosis. The changes of myocardial c ollagen content and serum procollagen peptide after LVAD support can be regarded as an expression of the reverse of maladaptive myocardial interstitial remodeling. | 梁红 Johannes Müller 翁渝国 Gerd Wallukat 付平 林汉生 Sabina Bartel Christoph Knosalla Reinhard Pregla Roland Hetzer | 2004 | Chinese Medical Journal2004，，3： | 3 |
| 2 | The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly 显示文摘 | HETZER M GRUSS O J MATI'AJ I W | 2002 | Nat Cell Biol2002，4，7： | 1 |
| 3 | Echocardiographic strain and strain rate imaging clinical application 显示文摘 | Dandel M Hetzer R | 2009 | Cardiol2009，132，： | 1 |
| 4 | Echocardiographic strain and strain rate imaging-clinical applications显示文摘 | Dandel M Hetzer R | 2009 | Int J Cardiol2009，132，1： | 1 |
| 5 | Echocardiographic strain and strain rate imaging-clinical applications显示文摘 | Dandel M Hetzer R | | 0，，01： | 1 |
| 6 | Echocardiographic strain and strain rate imaging--clinical applications显示文摘 | Dandel M Hetzer R | 2009 | Int J Cardiol2009，132，： | 1 |
| 7 | 查看详情显示文摘 | Hetzer M Chen G J Barner-Kowollik C Stenze M H | | 0，，02： | 1 |
| 8 | Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation显示文摘 | ANDERSON D J HETZER M W | 2008 | J Cell Biol2008，182，5： | 1 |
| 9 | Ran binds to chromatin by two distinct mechanisms 显示文摘 | BILBAO-CORTES D HETZER M LANGST G | 2002 | Curr Biol2002，12，13： | 1 |
| 10 | Surgery intermincal mitralvalvedieases显示文摘 | Bauer M Pasic M Hetzer R | 2001 | Z Kardiol2001，90，6： | 1 |
| 11 | Echocardiographic strain and strain rate imaging-clinical applications 显示文摘 | Dandel M Hetzer R | 2009 | Int Cardiol2009，132，1： | 1 |
| 12 | Echocardiographic strain andstrain rate imaging-clinical applications显示文摘 | Dandel M Hetzer R | 2009 | Int J Cardi-ol2009，132，1： | 1 |
| 13 | The relative basicities of trialkylamine and trialkylamine oxide in benzene and water 显示文摘 | DAVIS M M HETZER H B | 1954 | Am Chem Soc1954，76，： | 1 |
| 14 | Echocardiographic strain and strain rate imaging-clinical applications显示文摘 | Dandel M Hetzer R | | 0，，1： | 1 |
| 15 | Echocardiographic strain and strain rate imaging-clinical applications显示文摘 | Dandel M Hetzer R | 2009 | Int J Cardiol2009，132，1： | 1 |
| 16 | Echocardiographic strain and strain rate ima ging-clinical applications显示文摘 | DANDEL M HETZER R | 2009 | Int J Cardiol2009，132，1： | 1 |
| 17 | Echocardiographic strain and strain rate imaging-clinical applications 显示文摘 | Dandel M Hetzer R | 2009 | Int J Caraiol2009，132，1： | 1 |
| 18 | Blood contact with artificial surfaces during BVAD support显示文摘 | Hasper D Hummel M Hetzer R | 1996 | Int J Artif Organs1996，19，10： | 1 |
| 19 | Echocardiographic strain and strain rate ima- ging-Clinical applications 显示文摘 | Dandel M Hetzer R | 2009 | Int J Cardio12009，132，1： | 1 |
| 20 | Status of patients present- ly living 9 to 13 years after orthotopic heart transplantation显示文摘 | Hetzer R Albert W Hummel M | 1997 | Ann Thorac Surg1997，64，6： | 1 |
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