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| 1 | Unstable Head-Flow Characteristic Generation Mechanism of a Low Specific Speed Mixed Flow Pump显示文摘This paper treats the flow instabilities in a mixed flow pump with a vaned diffuser. Test pump has a positive slope of a head-flow performance curve at 65% flow rate of BEP (Best Efficiency Point) because of a rotating stall. Dynamic Particle Image Velocimetry (PIV) and pressure fluctuation measurements are used for investigating the propagation mechanism of a rotating stall. It was found that unstable performance was caused by periodical large scale abrupt backflow generated from the vaned diffuser to the outlet of impeller. Further, the relation between the static pressure at the inlet of diffuser vane and the internal flow condition was clarified. From these experimental results, in order to improve the positive slope of a head-flow performance curve, to suppress the growth of strong vortex toward the inlet of diffuser vane was proved to be a key point. | Masahiro MIYABE Hideaki MAEDA Isamu UMEKI Yoshinori JITTANI | 2006 | Journal of Thermal Science2006，15，2： | 53 |
| 2 | Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma显示文摘AIM: To assess the clinical features and prognosis of 151 patients with extrahepatic metastases from primary hepatocellular carcinoma (HCC), and describe the treatment strategy for such patients. METHODS: After the diagnosis of HCC, all 995 consecutive HCC patients were followed up at regular intervals and 151 (15.2%) patients were found to have extrahepatic metastases at the initial diagnosis of primary HCC or developed such tumors during the follow-up period. We assessed their clinical features, prognosis, and treatment strategies. RESULTS: The most frequent site of extrahepatic metastases was the lungs (47%), followed by lymph nodes (45%), bones (37%), and adrenal glands (12%). The cumulative survival rates after the initial diagnosis of extrahepatic metastases at 6, 12, 24, and 36 mo were 44.1%, 21.7%, 14.2%, 7.1%, respectively. The median survival time was 4.9 mo (range, 0-37 mo). Fourteen patients (11%) died of extrahepatic HCC, others died of primary HCC or liver failure. CONCLUSION: The prognosis of HCC patients with extrahepatic metastases is poor. With regard to the cause of death, many patients would die of intrahepatic HCC and few of extrahepatic metastases. Although most of HCC patients with extrahepatic metastases should undergo treatment for the primary HCC mainly, treatment of extrahepatic metastases in selected HCC patients who have good hepatic reserve, intrahepatictumor stage (T0-T2), and are free of portal venous invasion may improve survival. | Kiminori Uka Hiroshi Aikata Shintaro Takaki Hiroo Shirakawa Soo Cheol Jeong Keitaro Yamashina Akira Hiramatsu Hideaki Kodama Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，3： | 44 |
| 3 | Single-incision laparoscopic cholecystectomy:Single institution experience and literature review显示文摘Single-incision laparoscopic surgery is a rapidly evolving field as a bridge between traditional laparoscopic surgery and natural orifice transluminal endoscopic surgery.We report one of the initial clinical experiences in Japan with this new technique.Four cases of gallbladder diseases were selected for this new technique.A single curved intra-umbilical 25-mm incision was made by pulling out the umbilicus.A 12-mm trocar was placed through an open approach,and the abdominal cavity was explored with a 10-mm semiflexible laparoscope.Two 5-mm ports were inserted laterally from the laparoscope port.A 2-mm mini-loop retractor was inserted to retract the fundus of the gallbladder.Dissection was performed using an electric cautery hook and an Endograsper roticulator.There were two women and two men with a mean age of 50.5 years(range:40-61 years).All procedures were completed successfully without any perioperative complications.In all cases,there was no need to extend the skin incision.Average operative time was 88.8 min.Postoperative follow-up didnot reveal any umbili-cal wound complication.Single-incision laparoscopic cholecystectomy is feasible and a promising alternative method as scarless abdominal surgery for the treatment of some patients with gallbladder disease. | Yasumitsu Hirano Toru Watanabe Tsuneyuki Uchida Shuhei Yoshida Kanae Tawaraya Hideaki Kato Osamu Hosokawa | 2010 | World Journal of Gastroenterology2010，16，2： | 23 |
| 4 | Infrequent p53 gene mutation and expression of the cardia adenocarcinomas from a high-incidence area of Southwest China显示文摘INTRODUCTIONAdenocarcinomas of the cardia are the lesionsarising from the proximal stomach or within 3 cm ofthe gastroesophageal junction.These cancerstended to be advanced at the time of presentation,usually with poor prognosis.In recent decade,the incidence of adenocarcinoma of gastric eardiaand esophagus are increasing steadily,while therehas been a decrease in the proportion of the cancersarising from the distal stomach.The | Naoko lida Hideaki Oda Shigetoshi Aiso Takatoshi Ishikawa | 2000 | World Journal of Gastroenterology2000，6，5： | 17 |
| 5 | Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis显示文摘AIM:To elucidate the correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis(AL-LC).METHODS:The subjects included 35 patients with ALLC(34 men,1 woman;mean age,58.9±10.7 years;median age,61 years;range:37-76 years).All patientswere enrolled in this study after obtaining written informed consent.Liver function was measured with tests measuring albumin(Alb),prothrombin time(PT),brain natriuretic peptide(BNP),branched amino acid and tyrosine ratio(BTR),branched chain amino acid(BCAA),tyrosine,ammonia(NH3),cholinesterase(Ch E),immunoreactive insulin(IRI),total bile acid(TBA),and the retention rate of indocyanine green 15 min after administration(ICG R15).Hepatic blood flow,hepatic arterial tissue blood flow(HATBF),portal venous tissue blood flow(PVTBF),and total hepatic tissue blood flow(THTBF)were simultaneously calculated using xenon computed tomography.RESULTS:PVTBF,HATBF and THTBF were 30.2±10.4,20.0±10.7,and 50.3±14.9 m L/100 m L/min,respectively.Alb,PT,BNP,BTR,BCAA,tyrosine,NH3,Ch E,IRI,TBA,and ICG R15 were 3.50±0.50 g/d L,72.0%±11.5%,63.2±56.7 pg/m L,4.06±1.24,437.5±89.4μmol/L,117.7±32.8μmol/L,59.4±22.7μg/d L,161.0±70.8 IU/L,12.8±5.0μg/d L,68.0±51.8μmol/L,and 28.6%±13.5%,respectively.PVTBF showed a significant negative correlation with ICG R15(r=-0.468,P<0.01).No significant correlation was seen between ICG 15R,HATBF and THTBF.There was a significant correlation between PVTBF and Alb(r=0.2499,P<0.05),and NH3 tended to have an inverse correlation with PVTBF(r=-0.2428,P=0.0894).There were also many significant correlations between ICG R15 and liver function parameters,including Alb,NH3,PT,BNP,TBA,BCAA,and tyrosine(r=-0.2156,P<0.05;r=0.4318,P<0.01;r=0.4140,P<0.01;r=0.3610,P<0.05;r=0.5085,P<0.001;r=0.4496,P<0.01;and r=0.4740,P<0.05,respectively).CONCLUSION:Our investigation showed that there is a close correlation between liver function and hepatic blood flow. | Hideaki Takahashi Ryuta Shigefuku Yoshihito Yoshida Hiroki Ikeda Kotaro Matsunaga Nobuyuki Matsumoto Chiaki Okuse Shigeru Sase Fumio Itoh Michihiro Suzuki | 2014 | World Journal of Gastroenterology2014，20，45： | 14 |
| 6 | Treatment of over 20 mm gastric cancer by endoscopic submucosal dissection using an insulation-tipped diathermic knife显示文摘AIM: To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife (IT-ESD) for the treatment of patients with over 20 mm early gastric cancer (EGC). METHODS: A total of 112 patients with over 10 mm EGC were treated with IT-ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 5 year period from January 2002 to December 2006, including 40 patients with over 20 mm EGC. We compared patient backgrounds, the one-piece resection rate, complete resection (CR) rate, operation time, bleeding rate, perforation rate between patients with over 20 mm EGC [over 20 mm group (21-40 mm)] and the remaining patients (under 20 mm group). RESULTS: We found no significant difference in the rate of underlying cardiopulmonary disease (over 20 mm group vs under 20 mm group, 5.0% vs 5.6%), one- piece resection rate (95% vs 96%), CR rate (85% vs 89%), operation time (72.3 min vs 66.5 min), bleeding rate (5% vs 4.2%), and perforation rate (0% vs 1.4%) between the 2 groups. Three patients in each group had submucosal invasion and two in each groups underwent additional surgery. CONCLUSION: There was no significant difference in the outcome resulting from IT-ESD between the 2 groups. Our study proves that IT-ESD is a feasible treatment for patients with over 20 mm mucosal gastric cancer although the long-term outcome should be evaluated in the future. | Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei Fujita Fusao Ikeda Hideaki Taniguchi Eiichiro Yumoto Seiyuu Suzuki | 2007 | World Journal of Gastroenterology2007，13，29： | 13 |
| 7 | 激光诱导击穿光谱技术对钢中缺陷的快速表征显示文摘激光诱导击穿光谱技术(LIBS)作为一种快速而简单地检查钢表面缺陷的技术,可直接观测到激光脉冲被聚焦于样品之上而感生的等离子体发射物。一个平凸透镜把斑直径大约为1 mm的光量开关Nd:YAG激光器(脉宽:12 ns;重复频率:10 Hz)辐照聚焦于样品表面,用来烧蚀样品的一部分,形成一个微等离子体。等离子体的发射由光纤传送至帕邢-龙校格装置多色仪(焦距:500 mm)。在已被流入和流出的氩气排空的空间里,样品被安装在一个二维移动台上进行两点分析——常规分析和缺陷分析。通过比较两个分析结果,可检测到缺陷部分有显著信号强度的元素。由不同类型的夹杂物可以检测出典型的元素,由氧化铝可检测出铝,由保护渣可检测出铝、钙、镁、硅和钠,由矿渣可检测出铝、钙和镁。经证实,由LIBS分析得到的结果与EPMA(电子探针)研究得到的结果一致。因此,导致缺陷的夹杂物的类型都能通过LIBS技术确定属性。当涂层被激光烧蚀去掉后,镀锌钢也可以被直接分析出来。包括制样,该项技术评定时间不到半小时,因此在炼钢过程中,可以迅速采取合适措施。 | KONDO Hiroyuki AIMOTO Michihiro YAMAMURA Hideaki TOH Takehiko | 2009 | 冶金分析2009，29，1： | 13 |
| 8 | Decomposition patterns of leaf litter of seven common canopy species in a subtropical forest: dynamics of mineral nutrients显示文摘矿物质元素的动态模式在分解过程期间我们为七普通华盖种在的 reinvestigated 一副热带常绿树借助于在 2 年的崽袋子技术的阔叶的森林。学习的种类为在学习区域的植被是代表性的并且在他们的崽的化学质量显著地不同。没有重要关系在分解率之间被发现(百分比干燥集体留下和分解常数 k ) 并且起始的元素集中。然而,在为大多数盒子的在留下的崽的干燥集体留下和矿物质元素集中的百分比之间有重要关联。在分解过程的元素活动性的等级如下:Na= K >
Mg ≧ Ca >
N ≧ Mn ≧ Zn ≧ P >
Cu >
>
艾尔 >
>
Fe。当分解继续了, K 和 Na 的集中在所有种类减少了。当另外的元素(Zn, Cu,艾尔,和 Fe ) 的集中与在不同种类揭示了一个不同模式的 Mn 的例外为所有种类增加了时,钙和 Mg 也在集中,但是随分解的起始的阶段的永久增加减少了。在里面大多数种类,微型元件(Cu,艾尔,和 Fe ) 显著地在崽袋子孵化的结束在绝对数量增加了,它能被归功于到大程度到不能生活的固定的机制到腐殖的物质而非生物固定。 | XU Xiao-niu Hideaki SHIBATA Tsutomu ENOKI | 2006 | Journal of Forestry Research2006，17，1： | 12 |
| 9 | Conjugate Heat Transfer Analysis of Film Cooling Flows显示文摘这研究的目的是评估各种各样的格子的潜力令人满意地模仿一部冷却电影的发展,用考虑完整的几何学的 a coupled 计算。30 度的单个排的详细计算在一个扁平的盘子上绕行洞为吹 0.764, 1.01 和 1.54 的比率被介绍。模拟结果与试验性的数据被作比较很好。二层的模型给了更精确的结果,但是比标准墙工作的消费了更计算的时间。有有 y + 的适当的值的墙函数的 k- 蔚骚乱模型对实际使用合适。结果为精确地在冷却电影以内描述热转移的影响显示出 conjugate 计算的重要性。关键词拍摄冷却 - 结合热转移 - 刮的比率 CLC 数字 | Xiaochen LU Peixue JIANG Hideaki SUGISHITA Hideyuki UECHI Kiyoshi SUENAGA | 2006 | Journal of Thermal Science2006，15，1： | 12 |
| 10 | Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique显示文摘AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus(HCV) using superb microvascular imaging(SMI) and investigate the use of SMI in the evaluation of liver fibrosis.METHODS: SMI was performed in 100 HCV patients. SMI images were classified into five types according to the vascular pattern, and these patterns were compared with the fibrosis stage. Moreover, the images were analyzed to examine vascularity by integrating the number of SMI signals in the region of interest ROI [number of vascular trees(VT)]. The number of VT, fibrosis stage, serum parameters of liver function, and CD34 expression were investigated.RESULTS: There was a significant difference between SMI distribution pattern and fibrosis stage(P < 0.001). The mean VT values in each of the fibrosis stages were as follows: 26.69 ± 7.08 in F0, 27.72 ± 9.32 in F1, 36.74 ± 9.23 in F2, 37.36 ± 5.32 in F3, and 58.14 ± 14.08 in F4. The VT showed excellent diagnostic ability for F4 [area under the receiver operator characteristic(AUROC): 0.911]. The VT was significantly correlated with the CD34 labeling index(r = 0.617, P < 0.0001).CONCLUSION: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients. | Hidekatsu Kuroda Tamami Abe Keisuke Kakisaka Yudai Fujiwara Yuichi Yoshida Akio Miyasaka Kazuyuki Ishida Hideaki Ishida Tamotsu Sugai Yasuhiro Takikawa | 2016 | World Journal of Gastroenterology2016，22，26： | 12 |
| 11 | Review of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography using several endoscopic methods in patients with surgically altered gastrointestinal anatomy显示文摘The endoscopic approach for biliary diseases in patients with surgically altered gastrointestinal anatomy(SAGA) had been generally deemed impractical. However, it was radically made feasible by the introduction of double balloon endoscopy(DBE) that was originally developed for diagnosis and treatments for small-bowel diseases. Followed by the subsequent development of singleballoon endoscopy(SBE) and spiral endoscopy(SE), interventions using several endoscopes for biliary disease in patients with SAGA widely gained an acceptance as a new modality. Many studies have been made on this new technique. Yet, some problems are to be solved. For instance, the mutual unavailability among devices due to different working lengths and channels, and unestablished standardization of procedural techniques can be raised. Additionally, in an attempt to standardize endoscopic procedures, it is important to evaluate biliary cannulating methods by case with existence of papilla or not. A full comprehension of the features of respective scope types is also required. However there are not many papers written as a review. In our manuscript, we would like to evaluate and make a review of the present status of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography applying DBE, SBE and SE for biliary diseases in patients with SAGA for establishment of these modalities as a new technology and further improvement of the scopes and devices. | Masaaki Shimatani Makoto Takaoka Mitsuo Tokuhara Hideaki Miyoshi Tsukasa Ikeura Kazuichi Okazaki | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 11 |
| 12 | Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?显示文摘AIM:To investigate the effects of Helicobacter pylori (H pylori)eradication therapy for treatment of peptic ulcer on the incidence of gastric cancer. METHODS:A multicenter prospective cohort study was conducted between November 2000 and December 2007 in Yamagata Prefecture,Japan.The study included patients with H pylori-positive peptic ulcer who decided themselves whether to receive H pylori eradication(eradication group)or conventional antacid therapy(non-eradication group).Incidence of gastric cancer in the two groups was determined based on the results of annual endoscopy and questionnaire surveys,as well as Yamagata Prefectural Cancer Registry data,and was compared between the two groups and by results of H pylori therapy.RESULTS:A total of 4133 patients aged between 13 and 91 years(mean 52.9 years)were registered,and 56 cases of gastric cancer were identified over a mean follow-up of 5.6 years.The sex-and age-adjusted incidence ratio of gastric cancer in the eradication group, as compared with the non-eradication group,was 0.58 (95%CI:0.28-1.19)and ratios by follow-up period(<1 year,1-3 years,>3 years)were 1.16(0.27-5.00),0.50 (0.17-1.49),and 0.34(0.09-1.28),respectively.Longer follow-up tended to be associated with better prevention of gastric cancer,although not to a significant extent.No significant difference in incidence of gastric cancer was observed between patients with successful eradication therapy(32/2451 patients,1.31%)and those with treatment failure(11/639 patients,1.72%).Among patients with duodenal ulcer,which is known to be more prevalent in younger individuals,the incidence of gastric cancer was significantly less in those with successful eradication therapy(2/845 patients,0.24%)than in those with treatment failure(3/216 patients,1.39%). CONCLUSION:H pylori eradication therapy for peptic ulcer patients with a mean age of 52.9 years at registration did not significantly decrease the incidence of gastric cancer. | Katsuhiro Mabe Mikako Takahashi Haruhumi Oizumi Hideaki Tsukuma Akiko Shibata Kazutoshi Fukase Toru Matsuda Hiroaki Takeda Sumio Kawata | 2009 | World Journal of Gastroenterology2009，15，34： | 10 |
| 13 | Prognosis of hepatocellular carcinoma accompanied by microscopic portal vein invasion显示文摘AIM:To investigate the prognostic factors in patients with hepatocellular carcinoma(HCC) accompanied by microscopic portal vein invasion(PVI).METHODS:Of the 267 patients with HCC undergoing hepatic resection at Aso Iizuka Hospital,71 had PVI.After excluding 16 patients with HCC that invaded the main trunk and the first and second branches of the portal vein,55 patients with microscopic PVI were enrolled.RESULTS:The patients with HCC accompanied by microscopic invasion were divided into two groups:solitary PVI(PVI-S:n = 44),and multiple PVIs(PVI-M:n = 11).The number of portal vein branches invaded by tumor thrombi was 5.4 ± 3.8(2-16) in patients with PVI-M.In cumulative survival,PVI-M was found to be a significantly poor prognostic factor(P = 0.0019);while PVI-M and non-anatomical resection were significantly poor prognostic factors in disease-free survival(P = 0.0213,and 0.0115,respectively).In patients with PVI-M,multiple intrahepatic recurrence was more common than in the patients with PVI-S(P = 0.0049).In patients with PVI-S,non-anatomical resection was a significantly poor prognostic factor in disease-free survival(P = 0.0370).Operative procedure was not a significant prognostic factor in patients with PVI-M.CONCLUSION:The presence of PVI-M was a poor prognostic factor in patients with HCC,accompanied by microscopic PVI.Anatomical resection is recommended in these patients with HCC.Patients with HCC and PVI-M may also be good candidates for adjuvant chemotherapy. | Ken Shirabe Kiyoshi Kajiyama Norifumi Harimoto Hideaki Masumoto Tatsuro Fukuya Masafumi Ooya Yoshihiko Maehara | 2009 | World Journal of Gastroenterology2009，15，21： | 10 |
| 14 | Optimization of causative factors using logistic regression and artificial neural network models for landslide susceptibility assessment in Ujung Loe Watershed, South Sulawesi Indonesia显示文摘Landslide susceptibility maps(LSMs) play a vital role in assisting land use planning and risk mitigation. This study aims to optimize causative factors using logistic regression(LR) and an artificial neural network(ANN) to produce a LSM. The LSM is produced with 11 causative factors and then optimized using forward-stepwise LR(FSLR), ANN, and their combination(FSLR-ANN) until eight causative factors were found for each method. The ANN method produced superior validation results compared with LR. The ROC values for the training data set ranges between 0.8 and 0.9. On the other hand, validation with the percentage of landslide fall into LSM class high and very high, ANN method was higher(92.59%) than LR(82.12%). FSLR-ANN with nine causative factors gave the best validation results with respect to area under curve(AUC) values, and validation with the percentage of landslide fall into LSM class high and very high. In conclusion, ANN was found to be better than LR when producing LSMs. The best Optimization was combination of FSLR-ANN with nine causative factors and AUC success rate 0.847, predictive rate 0.844 and validation with landslide fall into high and very high class with 91.30%. It is an encouraging preliminary model towards a systematic introduction of FSLR-ANN model for optimization causative factors in landslide susceptibility assessment in the mountainous area of Ujung Loe Watershed. | Andang Suryana SOMA Tetsuya KUBOTA Hideaki MIZUNO | 2019 | Journal of Mountain Science2019，16，2： | 10 |
| 15 | 不同森林群落类型溪流水化学特征的季节动态显示文摘以小兴安岭凉水自然保护区内的阔叶红松林、云冷杉林和落叶松人工林为研究对象,于2006年3—10月,分析了其溪流水化学特征的动态变化.结果表明:不同月份3种森林群落溪流水的主要阳离子含量均表现为Ca2+>Na+>K+>Mg2+,主要阴离子含量均为HCO3->SO42->NO3->C l-;不同群落类型的主要离子含量影响显著,3种森林群落溪流水中Na+、Ca2+、Mg2+、Fe2+和Fe3+平均含量为云冷杉林>落叶松人工林>阔叶红松林,而K+为落叶松人工林>云冷杉林>阔叶红松林;主要阴离子平均含量均以落叶松人工林溪流水中为最高. | 石福臣 李凤英 蔡体久 Hideaki Shibata | 2008 | 应用生态学报2008，19，4： | 9 |
| 16 | Effects of acupuncture treatment on natural killer cell activity,pulse rate,and pain reduction for older adults:an uncontrolled,observational study显示文摘OBJECTIVE: The aim of this study was to examine the changes in natural killer (NK) cell activity, pulse rate, and pain intensity among older adults before and after acupuncture treatment. METHODS: Fifty-six individuals (16 males and 40 females), aged 60 to 82 years (mean age 72.4 ± 5.0), who were experiencing pain in the shoulder, low back, or knee, participated in the study. NK cell activity, leukocyte differentiation (granulocytes and lymphocytes), pulse rate, and blood pressure values were obtained. Pain intensity was evaluated by using the visual analog scale (VAS). The Wilcoxon test was used to analyze NK cell activity, leukocytes (granulocyte counts and granulocyte-to-lymphocyte ratio), and the VAS score in accordance with the location of pain complaints before and after acupuncture treatment. RESULTS: NK cell activity decreased after acupuncture treatment for pain in the shoulder-pain and knee-pain groups. Further, the lymphocyte and granulocyte counts increased after acupuncture treatment for the shoulder-pain group. Pulse rate decreased for the shoulder-pain, low-back-pain, and knee-pain groups after acupuncture treatment. The VAS score decreased after acupuncture treatment for the shoulder-pain, low-back-pain, and knee-pain groups. CONCLUSION: This study showed that in older adults, acupuncture treatment decreases pulse rate, relieves pain in the shoulder, low back, and knee, and reduces NK-cell activity. | Hidetoshi Mori Hiroshi Kuge Tim Hideaki Tanaka Eiichi Taniwaki Kazuyo Hanyu Tateyuki Morisawa | 2013 | Journal of Integrative Medicine2013，11，2： | 9 |
| 17 | Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes显示文摘Type 2 diabetes is one of the most prevalent and serious metabolic diseases.Under diabetic conditions,chronic hyperglycemia and subsequent induction of oxidative stress deteriorate pancreaticβ-cell function,which leads to the aggravation of type 2 diabetes.Although such phenomena are well known as glucose toxicity,its molecular mechanism remains unclear.In this review article,we describe the possible molecular mechanism forβ-cell dysfunction found in type 2 diabetes,focusing on(1)oxidative stress,(2)pancreatic transcription factors(PDX-1 and MafA)and(3)incretin receptors(GLP-1 and GIP receptors).Under such conditions,nuclear expression levels of PDX-1 and MafA are decreased,which leads to suppression of insulin biosynthesis and secretion.In addition,expression levels of GLP-1 and GIP receptors are decreased,which likely contributes to the impaired incretin effects found in diabetes.Taken together,it is likely that downregulation of pancreatic transcription factors(PDX-1and MafA)and down-regulation of incretin receptors(GLP-1 and GIP receptors)explain,at least in part,the molecular mechanism forβ-cell dysfunction found in type 2 diabetes. | Hideaki Kaneto Taka-aki Matsuoka | 2013 | World Journal of Diabetes2013，4，6： | 9 |
| 18 | Endoscopic retrograde pancreatography: When should we do it?显示文摘Endoscopic retrograde pancreatography(ERP) is an accurate imaging modality in the diagnosis of pancreatobiliary diseases. However, its use has been substantially reduced due to the invasiveness of procedure, the risk of complications and the widespread availability of non-invasive cross-section imaging techniques(computed tomography, magnetic resonance imaging, and endoscopic ultrasound). Since the introduction of endoscopic sphincterotomy, ERP has transformed from diagnostic method to an almost exclusively therapeutic procedure. Pancreatic duct injection substantially increased the risk of post-ERP pancreatitis(1.6%-15.7%); therefore, according to international guidelines ERP is recommended only in cases where biliary intervention is required. However, the role of ERP in the management of pancreatic diseases is currently not clearly defined, but in some cases the filling of pancreatic duct may provide essential information complementing the results of non-invasive imaging techniques. The aim of this publication is to systematically summarize the literature dealing with the diagnostic yield of ERP. We would like to define the precise indications of ERP and overview a diagnostic protocol of pancreatic diseases depending on international guidelines and the opinion of Hungarian experts, because it may improve the diagnostic accuracy, minimize of burden of patients and reduce the risk of procedure related complications. | Masaaki Shimatani Makoto Takaoka Mitsuo Tokuhara Hideaki Miyoshi Tsukasa Ikeura Kazuichi Okazaki | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，11： | 8 |
| 19 | Phase Ⅱ study of protracted irinotecan infusion and a low-dose cisplatin for metastatic gastric cancer显示文摘AIM: To test protracted irinotecan infusion plus a low-dose cisplatin in this Phase Ⅱ trial to decrease its toxic-ity. METHODS: The eligibility criteria were: (1) histologi-cally proven measurable gastric cancer; (2) performance status of 0 or 1; (3) no prior chemotherapy or comple-tion of prior therapy at least 4 wk before enrollment; (4) adequate function of major organs; (5) no other active malignancy; and (6) written informed consent. The regi-men consisted of irinotecan (60 mg/m2) on d 1 and 15 by 24-h infusion and cisplatin (10 mg/m2) on d 1, 2, 3, 15, 16, and 17. Treatment was repeated every 4 wk. RESULTS: Thirty-one patients were registered between April 2000 and January 2001. The response rate for all 31 patients, 20 patients without prior chemotherapy, and 11 patients with prior chemotherapy was 52% (16/31), 60% (12/20), and 36% (4/11), respectively. The median survival time was 378 d. The median number of courses given to all patients was 2. Grade 4 neutropenia oc-curred in 11 (35%) patients, while grade 3 to 4 diarrhea or nausea occurred in 1 (3%) and 3 (10%) patients, respectively. Fatigue was minimal as grade 1 fatigue was found only in 3 (10%) patients. Other adverse events were mild and no treatment-related deaths occurred.CONCLUSION: This regimen showed a high level of ac-tivity and acceptable toxicity in patients with metastatic gastric cancer. | Hiroshi Imamura Masataka Ikeda Hiroshi Furukawa Toshimasa Tsujinaka Kazumasa Fujitani Kenji Kobayashi Hiroyuki Narahara Michio Kato Haruhiko Imamoto Arimichi Takabayashi Hideaki Tsukuma | 2006 | World Journal of Gastroenterology2006，12，40： | 7 |
| 20 | Bed morphology and grain size characteristics around a spur dyke显示文摘这份报纸在透不过的刺激女同性恋附近在本地床形态学和谷物尺寸特征上论述试验性的研究。一系列实验与沉积床的不同类型被进行。沉积的异质在刺激塘附近对详细的床地形学施加影响,这被发现,但是不影响搜索免职形态学的典型特征。吝啬的谷物尺寸和床沉积的几何标准差是在在刺激塘附近描绘床形态学和床作文的变化的二个重要、实际的参数。排序过程的沉积在谷物尺寸分发起一个关键作用,并且这个过程发生纵,旁边地并且垂直地。在刺激塘的最近,床通常被变粗从对在上游下游并且由好粒子组成的沙带子被观察。在 scour 洞以内,底部沉积在顶是比那粗糙的。 | Hao ZHANG Hajime NAKAGAWA Hideaki MIZUTANI | 2012 | International Journal of Sediment Research2012，27，2： | 7 |
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