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| 1 | Clinical use of bone-targeting radiopharmaceuticals with focus on alpha-emitters显示文摘Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer.Different radionuclides that emitβ-rays such as 153Samarium and 89Strontium and achieve palliation are commercially available.In contrast toβ-emitters,223Radium as a a-emitter has a short path-length.The advantage of the a-emitter is thus a highly localized biological effect that is caused by radiation induced DNA double-strand breaks and subsequent cell killing and/or limited effectiveness of cellular repair mechanisms.Due to the limited range of the a-particles the bone surface to red bone marrow dose ratio is also lower for 223Radium which is expressed in a lower myelotoxicity.The a emitter 223Radium dichloride is the first radiopharmaceutical that significantly prolongslife in castrate resistant prostate cancer patients with wide-spread bone metastatic disease.In a phaseⅢ,randomized,double-blind,placebo-controlled study 921patients with castration-resistant prostate cancer and bone metastases were randomly assigned.The analysis confirmed the 223Radium survival benefit compared to the placebo(median,14.9 mo vs 11.3 mo;P<0.001).In addition,the treatment results in pain palliation and thus,improved quality of life and a delay of skeletal related events.At the same time the toxicity profile of223Radium was favourable.Since May 2013,223Radium dichloride(Xofigo?)is approved by the US Food and Drug Administration. | Hinrich A Wieder Michael Lassmann Martin S Allen-Auerbach Johannes Czernin Ken Herrmann | 2014 | World Journal of Radiology2014，6，7： | 4 |
| 2 | Fluorometric assay for bacterial primase 显示文摘 | Koepsell S A Hanson S Hinrichs S H | 2005 | Analytical Biochemistry2005，339，2： | 1 |
| 3 | Influence of partial sleep deprivation on energy balance and insulin sensitivity in healthy women 显示文摘 | Bosy-Westphal A Hinrichs S Jauch-Chara K | 2008 | Obes Facts2008，1，5： | 1 |
| 4 | Towards an oral influenza vaccine: comparison be- tween intragastric and intracolonie delivery of influen za subunit vaccine in a murine model显示文摘 | AMORIJ J P WESTRA T A HINRICHS W L | 2007 | Vaccine2007，26，1： | 1 |
| 5 | Microbial diversity of hydrothermal sediments in the Guaymas Basin: evidence for anaerobic methanotrophic communities显示文摘 | Teske A Hinrichs K U Edgcomb V | 2002 | Applied and Environmental Microbiology2002，68，4： | 1 |
| 6 | Microbial diver- sity of hydrothermal sediments in the Guaymas Basin: Evidence for anaerobic methanotrophic communities 显示文摘 | TESKE A HINRICHS K U EDGCOMB V | 2002 | Appl Environ Mi- crobio12002，68，： | 1 |
| 7 | Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity显示文摘 | HINRICHS C S BORMAN Z A CASSARD L | 2009 | Proc Natl Acad Sci USA2009，106，17： | 1 |
| 8 | Deter-mination of relative sensitivity factors for trace element analysis of solar cell silicon by fast-flow glow discharge mass spectrometry 显示文摘 | Di Sabatino M Dons A L Hinrichs J Amberg L | 2011 | Spectrochimica Acta Part B : Atomic Spectroscopy2011，66，2： | 1 |
| 9 | Changing sedimentation in tidal flat sediments of the southern North Sea from the Holocene to the present:a geochemical approach显示文摘 | Dellwig O Hinrichs J Hild A | 2000 | Journal of Sea Research2000，44，： | 1 |
| 10 | Rheology of a Lower Critical Solution Temperature Binary Polymer Blend in the Homogeneous, Phase-separated, and Transitional Regimes 显示文摘 | Kapnistos M Hinrichs A Vlassopoulos D | 1996 | Macromolecules1996，29，： | 1 |
| 11 | Improved texture of stirred fermented milk by integrating fat globules into the gel structure 显示文摘 | SCHKODA P HECHLER A HINRICHS J | 2001 | Milchwissenschaft Germany2001，56，： | 1 |
| 12 | Effects of stage of oestrous cycle and progesterone supplementation during cultureon maturation of canine oocytes in vitro显示文摘 | Willingham-Rocky L A Hinrichs K | 2003 | Reproduction2003，126，4： | 1 |
| 13 | Microbial diversity of hydrothermal, sediments in the Guaymas Basin: Evidence for anaerobic methanotrophic communities显示文摘 | Teske A Hinrichs KU Edgcomb V | 2002 | Applied and Environmental Microbiology2002，68，4： | 1 |
| 14 | Type 17 CD8+T cells display enhanced anti-tumor immunity显示文摘 | Hinrichs CS Kaiser A Paulos CM | 2009 | Blood2009，114，： | 1 |
| 15 | Removal of SO2 and Particulates with Copper-containing Absorbers显示文摘 | Kretchmer R A Hinrichs L M | 1986 | US1986，4，61： | 1 |
| 16 | Lymphogranuloma venereum-A rare cause of genital ulcers in central Europe显示文摘 | Rampf J Essig A Hinrichs R | 2004 | Dermatology2004，209，3： | 1 |
| 17 | Vibrational nano-spectroscopic imaging correlating structure with intermolecular coupling and dynamics显示文摘 | Pollard B Muller E A Hinrichs K | 2014 | Nature Communications2014，5，： | 1 |
| 18 | The choice of a suitable oligosaccharide to prevent aggregation of PEGylated nanoparticles during freeze thawing and freeze drying显示文摘 | HINRICHS W L J MANCENIDO F A SANDERS N N | 2006 | International Journal of Pharrnaceutics2006，311，12： | 1 |
| 19 | Type 17 CD8+ T cells display enhanced antitumor immunity 显示文摘 | Hinrichs CS Kaiser A Paulos CM | 2009 | Blood2009，114，3： | 1 |
| 20 | Genetic studies of alcoholism and substance dependence显示文摘 | Reich T Hinrichs A Culverhouse R | 1999 | Am J Hum Genet1999，65，： | 1 |
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