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	题名	作者	年代	出处	被引量
1	4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.	Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon	2017	Cellular & Molecular Immunology2017，14，9：	6
2	Ohioensins and pallidisetins:ovel cytotoxic agents from the moss polytrichum pallidisetum 显示文摘	ZHENG G HO D K ELDER P L	1994	J Nat Prod1994，57，1：	2
3	A cluster of cases of severe acute respiratory syndrome in Hong Kong 显示文摘	Tsang K W Ho P L Ooi G C	2003	N Engl J Med2003，31，：	1
4	Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘	Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C	2009	Nature2009，458，7238：	1
5	Biological markers of oxidative stress:Applications to cardiovascular research and practice 显示文摘	HO E KARIMI G K LIU C C	2013	Redox Biological2013，，1：	1
6	Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics显示文摘	Ho K K Moody G B Peng C K	1997	Circulation1997，96，3：	1
7	Preparation of highly photocatalytic active nano-sized TiO2 particles via ultrasonic irradiation 显示文摘	YU J C YU J G Ho W K	2001	Chem Commun2001，，19：	1
8	Proteomics in gastric cancer research: Benefits and challenges 显示文摘	Li J J Qi R Z Ho Ng G K	2009	Proteomics Clin Appl2009，3，2：	1
9	Effects of F-doping on the Photocatalytic Activity and Microstructures of Nanocrystalline TiO2 Powders显示文摘	Yu J C Yu J G Ho W K	2002	Chem Mater2002，14，9：	1
10	Characterization of selected volatile organic compounds, polycyclic aromatic hydrocarbons and carbonyl compounds at a roadside monitoring station 显示文摘	Ho K F Lee S C Chiu G M Y	2002	Atmospheric Envi- ronment2002，36，1：	1
11	A cluster of cases of severe acute respiratory syndrome in Hong kong显示文摘	Tsang K W Ho P L Ooi G C	2003	New Engl J Med2003，348，20：	1
12	Residence time distribution analysis in controllable flow conditions : Case of rotating disc reactor 显示文摘	Myung J K Yong S G Ho N C	1984	Chemical Engineering Science1984，39，5：	1
13	A cluster of cases of severe acute respiratory syndrome in Hong Kong 显示文摘	Tsang K W Ho P L Ooi G C	2003	N Engl Jmed2003，348，：	1
14	Anodophilic biofilm cata- lyzes cathodic oxygen reduction 显示文摘	Cheng K Y Ho G Cord-Ruwisch R A	2010	Environmental Science and Technology2010，44，1：	1
15	Selective adsorbents from ordered mesoporous silica显示文摘	HO K Y MCKAY G YEUNG K L	2003	Langmuir2003，19，7：	1
16	Design and Development of Agent- based Procurement System to Enhance Business Intelligence显示文摘	LEE( K M LAU H C W HO G T S el al	2009	Expert Systems with Applications2009，36，1：	1
17	A ruthenium complex with superhigh light-harvesting capacity for dye-sensitized solar cells显示文摘	Chen C Y Wu S J Wu C G Chen J G Ho K C		0，，35：	1
18	显示文摘	Yu J C Yu J G Ho W K	2002	Chem Mater2002，14，：	1
19	Corporate ownership structure and the informativeness of earnings显示文摘	Yeo G H Tan P M Ho K M Sheng- Syan Chen	2002	Joumal of Bussiness Finance and Accounting2002，29，7：	1
20	Wealth Effects of Private Equity Placements:Evidence from Singapore显示文摘	Chen S Ho K W Lee C Yeo G	2002	The Financial Review2002，，37：	1

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