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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Colorectal neoplasia in Asia: a multicenter colonscopy survey in symptomatic patients显示文摘 | LEUNG W K HO K Y KIM W H | 2006 | Gastrointest Endosc2006，64，： | 1 |
| 3 | Using the Oxford classification of IgA nephropathy to predict long-term outcomes of Henoch-SchSnlein purpura nephritis in adults 显示文摘 | Ho Kim C Jin Lim B Sung Bae Y | 2014 | Modem Pathology2014，27，7： | 1 |
| 4 | A compact hall-effect-sensing 6-DOFprecision positioner 显示文摘 | Ho Y Kim W J | 2010 | IEEE/ASME Transactionson Mechatronics2010，，6： | 1 |
| 5 | Intestinal goblet cells and mucins in health and disease: recent insights and progress 显示文摘 | Kim Y S Ho S B | 2010 | Curr Gastroentero! Rep2010，12，5： | 1 |
| 6 | Comparison of the condyle-fossa relationship between skeletal class ill malocclusion patients with and without asymmetry-a retrospective three-dimensional cone-beam com?puted tomograpy study显示文摘 | Kim HO Lee W Kook Y A | 2013 | Korean J Orthod2013，43，5： | 1 |
| 7 | 3D video player system with haptic interaction based on depth image-based representation显示文摘 | Cha J Kim S Y Ho Y S | 2006 | IEEE Transactions on Consumer Electronics2006，52，2： | 1 |
| 8 | Midfield wireless powering for implantable systems 显示文摘 | HO J S KIM S POON A S Y | 2013 | Proceedings of the IEEE2013，101，6： | 1 |
| 9 | Gene frequencies of the five major human platelet antigens in African American, white,and Korean population显示文摘 | Kim HO Jin Y Kickler TS | 1995 | Transfution1995，35，10： | 1 |
| 10 | Predictive compression of geometry, color and normal data of 3-D mesh models 显示文摘 | Ahn J H Kim C S Ho Y S | 2006 | IEEE Transactions on Circuits and Systems for Video Technology2006，2，16： | 1 |
| 11 | Development of a new injection molding technology : Momentary mold surface heating process显示文摘 | Kim Dongak Kangmyung Ho Chun Y H | 2001 | Journal of Injection Molding Technology2001，5，22： | 1 |
| 12 | Dynamic simulation of a fish cage system subjected to currents and waves 显示文摘 | Lee C W Kim Y B Ho G | 2008 | Ocean Eng2008，35，： | 1 |
| 13 | The impact of aerosols on the summer rainfall frequency in China显示文摘 | CHOI Y S HO C H KIM J Y | 2008 | J Appl Meteor2008，47，6： | 1 |
| 14 | Structure and mechanical properties of ZrCrAlN nanostructured thin films by closed-field unbalanced magnetron sputtefing显示文摘 | Youn J Kim Ho Y Lee Yong M Kim | 2007 | Surface & Coatings Technology2007，201，： | 1 |
| 15 | A theoretical model for the evaluation of measurement uncertainty of a sound level meter calibration by comparison method in an anechoic room显示文摘 | Kim Y T Lee Y B J ho M J | 2004 | Applied Acoustics2004，65，3： | 1 |
| 16 | Formation process and microstruetural evolution of Ni-silicide layers grown by chemical vapor deposition of Si on Ni substrates显示文摘 | JIN-KOOK Y JI YOUNG B GYEUNG HO Kim | 2003 | Surface and Coatings Technology2003，168，23： | 1 |
| 17 | Gene frequencies of the five major human platelet antigens in African American,white,and Korean populations显示文摘 | Kim HO Jin Y Kickler TS | | 0，，10： | 1 |
| 18 | Differential effect of Coriolus versicolor ( Yunzhi ) extract on cytokine production by murine lymphocytes in vitro 显示文摘 | HO C Y LAU C B KIM C F | 2004 | Int Immunopharmacol2004，4，12： | 1 |
| 19 | Validation study of the Korean version of the McGill Quality of Life Questionnaire显示文摘 | Hyun Kim S Kyung Gu S Ho Yun Y | 2007 | Palliat Med2007，21，5： | 1 |
| 20 | Gene frequencies of the five major human platelet antigens in African American,White and Korean populations显示文摘 | Kim HO Jin Y Kickler TS | 1995 | Transfusion1995，35，10： | 1 |
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