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| 1 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 2 | The Impact of Satisfaction and Payment Equity on Cross - buying: A Dynamic Model for a Multi - service Provider 显示文摘 | Verhoef P C Franses P H Hoekstra J C | 2001 | Journal of Retailing2001，77，3： | 1 |
| 3 | Portal venous flow and followup in patients with liver disease and healthy subjects显示文摘 | Vries PJ Hoekstra JBL Hooge P | 1994 | Seand J Gastroenterol1994，29，： | 1 |
| 4 | Modelling of microstructured waveguides using a finite-element-based vectorial mode solver with transparent boundary conditions 显示文摘 | URANUS H P HOEKSTRA H J W M | 2004 | Opt Express2004，12，： | 1 |
| 5 | Estrogenic activity of dicofol with the human estrogen recep- tor: isomer-and enantiomer-specific implications 显示文摘 | Hoekstra P F Burnison B K Garrison A W | 2006 | Chemosphere2006，64，1： | 1 |
| 6 | Associa- tion of small life events with self reports of tic severity in pe- diatric and adult tic disorder patients : a prospective longitudi- nal study显示文摘 | Hoekstra P J Steenhuis MP Kallenberg CG | 2004 | J Clin Psychiatry2004，65，： | 1 |
| 7 | Going against the flow: A critical analysis of inter - state virtual water trade in the context of India's National River Linking Program 显示文摘 | VERMA S KAMPMAN D A ZAAG P HOEKSTRA A Y | 2009 | Physics and Chemistry of the Earth2009，34，45： | 1 |
| 8 | Globalisation of water resources:international virtual water flows in relation to crop trade显示文摘 | Hoekstra A Y Hung P Q | 2005 | Global Environmental Changes2005，，15： | 1 |
| 9 | The external water footprint of the Netherlands: Geographically-explicit quantification and impact assessment显示文摘 | Van Oel P R Mekonnen M M Hoekstra A Y | 2009 | Ecological Econom- ics2009，69，1： | 1 |
| 10 | Is 18F23' 2flu2oro23' 2deoxy2L2thymidine useful for the staging and restaging of non2small cell lung cancer显示文摘 | Cobber D C Elsinga P H Hoekstra H J | 2004 | J NuclMed2004，45，10： | 1 |
| 11 | Globalization of water resources : international virtual water flows in relation to crop trade 显示文摘 | Hoekstra A Y Hung P Q | 2005 | Global Environ Chang2005，，15： | 1 |
| 12 | Modeling of loss-in- duced superluminal and negative group velocity in two- port ring-resonator circuits 显示文摘 | Uranus H P Hoekstra H J W | 2007 | Journal of Lightwave Technology2007，25，9： | 1 |
| 13 | In vitro comparison of two bioartificial liver support systems: MEIS Cell Module and AMC-BAL显示文摘 | Poyck P P Pless G Hoekstra R | 2007 | Int J Artif Organs2007，30，3： | 1 |
| 14 | Sexual dysfunction in nonseminoma testicular cancer patients is related to chemotherapy-induced angiopathy显示文摘 | van Basten J P Hoekstra H J van Driel M F | 1997 | J Clin Oncol1997，15，6： | 1 |
| 15 | The External Water Footprint of the Netherlands: Geo- graphically-explicit Quantification and Impact As sessment显示文摘 | Van Oel P R Mekonnen M M Hoekstra A Y | 2009 | Ecological Economics2009，69，1： | 1 |
| 16 | Calculation of the EC50 and its confidence interval when subtoxic stimulus is present 显示文摘 | Van EWIJK P H HOEKSTRA J A | 1993 | Ecotuxicology and Environmental Safety1993，25，： | 1 |
| 17 | Anaphylaxis and severe systemic reactions caused by skin contact with persulfates in hair-bleaching products显示文摘 | HOEKSTRA M van der HEIDE S COENRAADS P J | 2012 | Contact Dermatitis2012，66，6： | 1 |
| 18 | Par- tial volume correction strategies for quantitative FDG PET in oncology 显示文摘 | Hoetjes N J Velden F H P Hoekstra O S | 2010 | Eur J Nucl Med Mol Imaging2010，37，9： | 1 |
| 19 | Is 18F-3′-fluoro-3′-deoxy-L-thymidine useful for the staging and restaging of non-small cell lung cancer?显示文摘 | COBBEN D C ELSINGA P H HOEKSTRA H J | 2004 | J Nucl Med2004，45，10： | 1 |
| 20 | Calculation of the EC50 and its confidence interval when subtoxic stimulus is present显示文摘 | Van Ewijk P H Hoekstra J A | 1993 | Ecotoxicology and Environmental Safety1993，25，： | 1 |
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