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| 1 | Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation显示文摘Splenomegaly is a well-known phenomenon typically associated with inflammation.However,the underlying cause of this phenotype has not been well characterized.Furthermore,the splenomegaly phenotype seen in lymphotoxin(LT)signaling-deficient mice is characterized by increased numbers of splenocytes and splenic neutrophils.Splenomegaly,as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues,is thought to result from the absence of secondary lymphoid tissues in LT-deficient mice.We now present evidence that mice deficient in LTα1β2 or LTβR develop splenomegaly and increased numbers of lymphocytes in non-lymphoid tissues in a microbiota-dependent manner.Antibiotic administration to LTα1β2-or LTβR-deficient mice reduces splenomegaly.Furthermore,re-derived germ-free Ltbr−/−mice do not exhibit splenomegaly or increased inflammation in non-lymphoid tissues compared to specific pathogen-free Ltbr−/−mice.By using various LTβ-and LTβR-conditional knockout mice,we demonstrate that retinoic acid-related orphan receptorγT-positive type 3 innate lymphoid cells provide the required active LT signaling to prevent the development of splenomegaly.Thus,this study demonstrates the importance of LT-mediated immune responses for the prevention of splenomegaly and systemic inflammation induced by microbiota. | Yuan Zhang Tae-Jin Kim Joanna A Wroblewska Vera Tesic Vaibhav Upadhyay Ralph R Weichselbaum Alexei V Tumanov Hong Tang Xiaohuan Guo Haidong Tang Yang-Xin Fu | 2018 | Cellular & Molecular Immunology2018，15，7： | 3 |
| 2 | On-line fingerprint verification 显示文摘 | Jain A K Hong L Bolle R | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，4： | 1 |
| 3 | The impact of daily setup variations on head and-neck intensity-modulated radiation therapy显示文摘 | Hong T S Tome W A Chappell R J | 2005 | Int J Radiat Oneol Biol Phys2005，61，3： | 1 |
| 4 | Epitaxial Cubic Gadolinium Oxide as a Dielectric for Gallium Arsenide Passivation显示文摘 | Hong M Kwo J Kortan A R | 1999 | Science1999，283，5409： | 1 |
| 5 | Extremely high prevalence of neural tube defects in a 4 - county area in Shanxi Province, China 显示文摘 | Li Z Ren A Zhang L Ye R Li S Zheng J Hong S Wang T Li Z | 2006 | Birth Defects Res A Clin Mol Teratol2006，76，4： | 1 |
| 6 | Variable- temperature microelectrode voltammetry: applica- tion to diffusion coefficients and electrode reaction mechanisms 显示文摘 | JAXOB A R HONG Q COLES B A | 1999 | J Phys Chem B1999，，103： | 1 |
| 7 | Online fingerprint verification显示文摘 | JAIN A K HONG L BOLLE R | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，4： | 1 |
| 8 | Kinetics of adiabatic anionic copolymerization of ε-caprolactam in the presence of various activators 显示文摘 | Kim K J Hong D S Tripathy A R | 1997 | Journal of Applied Polymer Science1997，66，6： | 1 |
| 9 | Nucleotide sequence of bacteriophage lambda DNA显示文摘 | Sanger F Coulson A R Hong G F | 1982 | J Mol Biol1982，162，： | 1 |
| 10 | On-line fingerprint verification显示文摘 | Jain A Hong L Bolle R | 1997 | IEEE Transactions on PAMI1997，19，4： | 1 |
| 11 | Regulatory elements of the floral homeotie gene AGAMOUS identified by phylogenetic footprinting and shadowing显示文摘 | HONG R L HAMAGUCHI L H BUSCH M A WEIGEL D | 2003 | The Plant Cell2003，15，： | 1 |
| 12 | On-line fingerprint verification显示文摘 | Jain A Hong Lin Bolle R | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelli-gence1997，19，4： | 1 |
| 13 | ECG-gated reconstructed multi- detector row CT coronary angiography:effect of varying trigger delay on image quality 显示文摘 | Hong C Becker C R Huber A | 2001 | Radiology2001，220，3： | 1 |
| 14 | A cytochrome P450 serves as an unexpected terpene eyclase during fungal meroterpe- noid biosynthesis显示文摘 | Chooi Y-H Hong Y J Cacho R A | 2013 | Journal of the American Chemical Society2013，135，16： | 1 |
| 15 | On-line fingerprint verification 显示文摘 | Jain A K Hong L Bolle R | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，4： | 1 |
| 16 | Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease 显示文摘 | Hong Ye Tracey A R | 2010 | Biochemistry2010，49，24： | 1 |
| 17 | Perceptual Focus Effects in Choice显示文摘 | HAMILTON R HONG J CHERNEV A | 2007 | Journal of Consumer Research2007，34，18： | 1 |
| 18 | Structure of an elastin-mimetic polypeptide by solid-state NMR chemical shift analysis显示文摘 | Hong M Isailovic D McMillan R A | 2003 | Biopolymers2003，70，2： | 1 |
| 19 | Significance of intracellular localiza- tion of survivin in cervical squamous cell lesions: Corre- lation with disease progression显示文摘 | KIM S A HONG R | 2014 | Oncol Lett2014，7，5： | 1 |
| 20 | Tensile extension properties and deformation mechanisms of multiaxial noncrimp fabrics显示文摘 | HU Hong MOURIT A P PATON Z R | 2004 | Composite Structure2004，，66： | 1 |
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