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| 1 | Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins显示文摘AIM: To examine the influence of dexamethasone on pancreatitis-associated protein (PAP) gene expression using both in vitro and in vivo models of acute pancreati- tis and to study how PAP gene expression correlates with severity of pancreatitis. METHODS: In vitro, IL-6 stimulated pancreas acinar AR42J cells were cultured with increasing concentrations of dexamethasone and assayed for PAP expression (RT-PCR). In vivo , pancreatitis was induced in rats by retrograde injection of 40 g/L taurocholate into the pancreatic duct. Animals were pretreated with dexamethasone (2 mg/kg) daily or saline for 4 d. Pancreata and serum were harvested after 24 h and gene expression levels of PAPⅠ, Ⅱ and Ⅲ were measured by RT-PCR. Severity of pancreatitis was based on serum amylase, pancreatic wet weight, and histopathological score. RESULTS: In vitro, dexamethasone and IL-6 induced a marked transcription of PAPⅠ, Ⅱ and Ⅲ genes in AR42J cells at 24 h (P < 0.05 for all comparisons). In vivo, pancreas mRNA levels of PAPⅠ, Ⅱ or Ⅲ increased by 2.6-fold, 1.9-fold, and 1.3-fold respectively after dexa- methasone treatment, compared with saline treated ani- mals. Serum amylase levels and edema were significantly lower in the dexamethasone group compared with the saline group. Histopathologic evaluation revealed less inflammation and necrosis in pancreata obtained from dexamethasone treated animals (P < 0.05). CONCLUSION: Dexamethasone significantly decreases the severity of pancreatitis. The protective mechanism ofdexamethasone may be via upregulating PAP gene ex- pression during injury. | Emad Kandil Yin-Yao Lin Martin H Bluth Hong Zhang Gabriel Levi Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
| 2 | A comparison of the low moisture content limit to the logarithmic relation between seed moisture content and longevity in twelve species显示文摘 | Ellis R H Hong T D Roberts E H | 1989 | Annals of Botany1989，，63： | 1 |
| 3 | Genetic vari- ations in the sodium balance-regulating genes ENaC, NEDD4L, NDFIP2 and USP2 influence blood pres- sure and hypertension显示文摘 | JIN H S HONG K W LIM J E | 2010 | Kidney Blood Press Res2010，33，： | 1 |
| 4 | A novel cleavage product formed by autoxidation of lycopene induces apoptosis in HL-60 cells显示文摘 | ZHANG Hong KOTAKE-NARA E ONO H | 2003 | Free Radic Biol Med2003，35，12： | 1 |
| 5 | A low-moisture-content limit to logarithmic relation between seed moisture content and longevity显示文摘 | Ellis R H Hong T D Roberts E H | 1989 | Annals of Botany1989，61，： | 1 |
| 6 | Association of re- sistance to avian coccidiosis with single nucleotide polymorphisms in the Zyxin gene 显示文摘 | Hong Y Kim E S Lillehoj H | 2009 | Poultry Sci- ence2009，88，3： | 1 |
| 7 | Tunable refractive index of magnetic fluids and its applications 显示文摘 | C Y Hong H E Horng S Y Yang | 2004 | Physica Status Solidi C2004，1，7： | 1 |
| 8 | Data cleaning: problems and current approaches显示文摘 | Rahm E Hong H D | 2000 | IEEE Data Engineering Bulletin2000，23，4： | 1 |
| 9 | Expression of cytokeratins 7 and 20 in primary carcinomas of the stomach and colorectum and their value in the differential diagnosis of metastatic carcinomas to the ovary显示文摘 | Park S K Kim H S Hong E K Kim W H | 2002 | Hum Patho12002，33，11： | 1 |
| 10 | Low moisture content limit to relation between seed longevity and moisture显示文摘 | Ellis R H Hong T D Roberts E H | 1990 | Annals of Botany1990，，65： | 1 |
| 11 | A potyvirus P1 protein interacts with the Rieske Fe/S protein of its host 显示文摘 | Shi Y H Chen J Hong X E | 2007 | Molecular Plant Pathology2007，8，6： | 1 |
| 12 | Low moisture content limits or relation between seed longevity and moisture显示文摘 | Ellis R H Hong T D Roberts E H | 1990 | Annals of Botany1990，，65： | 1 |
| 13 | Electroencephalographic study of drowsiness insimulated driving with sleep deprivation显示文摘 | HONG J E MIN K C KIM S H | 2005 | International Journal of Industrial Ergonomics2005，35，4： | 1 |
| 14 | Wheat pentosans Ⅱ: estimating kernel hardness and pentosans in water extracts by Near-Infrared Reflectance 显示文摘 | Hong B H Rubenthater G L Allen R E | 1989 | Cereal Chem1989，66，5： | 1 |
| 15 | Translation elongation factor 1-α gene from Pichia pastoris:molecular cloning,sequence,and use of its promoter显示文摘 | Ahn J Hong J Lee H Park M Lee E Kim C Choi E Jung J Lee H | 2007 | Applied Microbiology and Biotechnology2007，74，： | 1 |
| 16 | Moisture content and the longevity of seeds of Phascolus vulgaris 显示文摘 | Ellis R H Hong T D Roberts E H | 1990 | Annals of Botany1990，，66： | 1 |
| 17 | Context-aware system: a literature review and classification 显示文摘 | HONG J Y SUH E H KIM S J | 2009 | Expert Systems with Applications2009，36，4： | 1 |
| 18 | Wheat pentosans Ⅰ: cultivar variation and relationship to Kernel hardness 显示文摘 | Hong B H Rubent'hater G L Allen R E | 1989 | Cereal Chem1989，66，5： | 1 |
| 19 | Extra axillary sentinel node biopsy in the management of early breast cancer显示文摘 | Hong J Choy E Soni H | 2005 | Eur J Surg Oncol2005，31，9： | 1 |
| 20 | Partial cylindrical algebraic deeom- position for quantifier dimination显示文摘 | Collins G E Hong H | 1991 | Journal of Symbolic Computation1991，12，： | 1 |
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