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| 1 | Effects of Enriched Biochars Containing Magnetic Iron Nanoparticles on Mycorrhizal Colonisation,Plant Growth,Nutrient Uptake and Soil Quality Improvement显示文摘At present, there is little commercial sale of biochar, since farmers find they can not gain a return on their investment in this amendment in the first few years after its application, because of the high cost associated with large application rates. To overcome this constraint, development of artificially aged enriched biochar-mineral complexes(BMCs), having a higher mineral content, surface functionality, exchangeable cations, high concentration of magnetic iron(Fe) nanoparticles, and higher water-extractable organic compounds has been undertaken by a combined team of researchers and a commercial company. Two biochars produced under different pyrolysis conditions were activated with a phosphoric acid treatment. A mixture of clay, chicken litter, and minerals were added to the biochar, and then this composite was torrefied at either 180 or 220?C. In this study a pot experiment was carried out in glasshouse conditions to determine the effects of four different BMCs, with different formulations applied at rates of 100 and 200 kg ha-1, on the mycorrhizal colonisation, wheat growth and nutrient uptake, and soil quality improvement. It was found that the phosphorus(P) and nitrogen uptake in wheat shoots were significantly greater for a low application rate of BMCs(100 kg ha-1). The present formulation of BMC was effective in enhancing growth of wheat at low application rate(100 kg ha-1). The increase in growth appeared due to an increase in P uptake in the plants that could be partly attributed to an increase in mycorrhizal colonisation and partly due to the properties of the BMC. | Stephen JOSEPH Hossain M.ANAWAR Paul STORER Paul BLACKWELL Chee CHIA Yun LIN Paul MUNROE Scott DONNE Josip HORVAT Jianli WANG Zakaria M.SOLAIMAN | 2015 | Pedosphere2015，25，5： | 7 |
| 2 | Effects of transferrin on the growth and proliferation of porcine hepatocytes:a comparison with epidermal growth factor and nicotinamide显示文摘Objective To seek an appropriate culture condition in which porcine hepatocytes can continuously proliferate and express their normal differentiation phenotypes for a longer period of time. Methods Different types and dosages of reagents,transferrin,epidermal growth factor and nicotinamide were used to culture porcine hepatocytes in serum-free Dulbecco’s modified Eagle’s medium (DMEM). And the proliferative effects and functions of the cells were detected at different culture times. Results Transferrin at 5 ng/ml,nicotinamide at 10 mmol/L and epidermal growth factor at 10 ng/ml had better effects on the viability of hepatocytes than DMEM,DMEM+10% fetal cattle serum FCS and other dosages of these reagents ( P <0.05). OD values of MTS were still high in culture at day 7 and day 10,while nearly 30%-35% cells went into the S phase. Good hepatocyte funcitons were found in these groups,and the secretion of albumin was positively correlated with OD value of MTS. The levels of aspartate transaminase and ammonia in these media were lower than those in DMEM and DMEM+FCS.Conclusion Transferrin at 5 ng/ml,epidermal growth factor at 10 ng/ml and nicotinamide at 10 mmol/L are benefitial to the viability and proliferation of hepatocytes. | 刘玉兰 孙君泓 张捷 张丽丽 Gretel Horvat | 2003 | Chinese Medical Journal2003，，8： | 7 |
| 3 | Evaluation of mercury biogeochemical cycling at the sediment–water interface in anthropogenically modified lagoon environments显示文摘The Marano and Grado Lagoon is well known for being contaminated by mercury(Hg) from the Idrija mine(Slovenia) and the decommissioned chlor-alkali plant of Torviscosa(Italy).Experimental activities were conducted in a local fish farm to understand Hg cycling at the sediment–water interface. Both diffusive and benthic fluxes were estimated in terms of chemical and physical features. Mercury concentration in sediments(up to 6.81 μg/g)showed a slight variability with depth, whereas the highest methylmercury(MeHg) values(up to 10 ng/g) were detected in the first centimetres. MeHg seems to be produced and stored in the 2–3 cm below the sediment–water interface, where sulphate reducing bacteria activity occurs and hypoxic–anoxic conditions become persistent for days. DMeHg in porewaters varied seasonally(from 0.1 and 17% of dissolved Hg(DHg)) with the highest concentrations in summer. DHg diffusive effluxes higher(up to 444 ng/m^2/day) than those reported in the open lagoon(~ 95 ng/m^2/day), whereas DMeHg showed influxes in the fish farm(up to-156 ng/m^2/day). The diurnal DHg and DMeHg benthic fluxes were found to be higher than the highest summer values previously reported for the natural lagoon environment. Bottom sediments, especially in anoxic conditions, seem to be a significant source of MeHg in the water column where it eventually accumulates. However, net fluxes considering the daily trend of DHg and DMeHg, indicated possible DMeHg degradation processes. Enhancing water dynamics in the fish farm could mitigate environmental conditions suitable for Hg methylation. | Elisa Petranich Stefano Covelli Alessandro Acquavita Jadran Faganeli Milena Horvat Marco Contin | 2018 | Journal of Environmental Sciences2018，30，6： | 4 |
| 4 | Current status and future perspectives of radiomics in hepatocellular carcinoma显示文摘Given the frequent co-existence of an aggressive tumor and underlying chronic liver disease,the management of hepatocellular carcinoma(HCC)patients requires experienced multidisciplinary team discussion.Moreover,imaging plays a key role in the diagnosis,staging,restaging,and surveillance of HCC.Currently,imaging assessment of HCC entails the assessment of qualitative characteristics which are prone to inter-reader variability.Radiomics is an emerging field that extracts high-dimensional mineable quantitative features that cannot be assessed visually with the naked eye from medical imaging.The main potential applications of radiomic models in HCC are to predict histology,response to treatment,genetic signature,recurrence,and survival.Despite the encouraging results to date,there are challenges and limitations that need to be overcome before radiomics implementation in clinical practice.The purpose of this article is to review the main concepts and challenges pertaining to radiomics,and to review recent studies and potential applications of radiomics in HCC. | Joao Miranda Natally Horvat Gilton Marques Fonseca Jose de Arimateia Batista Araujo-Filho Maria ClaraFernandes Charlotte Charbel Jayasree Chakraborty Fabricio Ferreira Coelho Cesar Higa Nomura Paulo Herman | 2023 | World Journal of Gastroenterology2023，29，1： | 3 |
| 5 | Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in ratsPentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats显示文摘BACKGROUND Recently,as a possible therapy resolving solution,pentadecapeptide BPC 157 therapy,has been used in alleviating various vascular occlusion disturbances.BPC 157 was previously reviewed as novel mediator of Robert cytoprotection and endothelium protection in the stomach,and gut-brain axis,beneficial therapy in gastrointestinal tract,with particular reference to vascular recruitment,ulcerative colitis and tumor cachexia,and other tissues healing.Here we raised new hypothesis about BPC 157 therapy in the Budd-Chiari syndrome in rats,rapid bypassing of the suprahepatic inferior caval vein occlusion,and rats recovery with the active and effective pharmacotherapy treatment.AIM To investigate Budd-Chiari syndrome model(inferior caval vein suprahepatic occlusion)resolution,since BPC 157 resolves various rat vascular occlusion.METHODS We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt,counteracted caval/portal hypertension,aortal hypotension,venous/arterial thrombosis,electrocardiogram disturbances,liver and gastrointestinal lesions(i.e.,stomach and duodenum hemorrhages,in particular,congestion).Rats with suprahepatic occlusion of the inferior vena cava by ligation were medicated at 1 min,15 min,24 h,or 48 h post-ligation.Medication consisted of 10μg/kg BPC 157,10 ng BPC 157 or 5 m L/kg saline,administered once as an abdominal bath or intragastric application.Gross and microscopic observations were made,in addition to assessments of electrical activity of the heart(electrocardiogram),portal and caval hypertension,aortal hypotension,thrombosis,hepatomegaly,splenomegaly and venography.Furthermore,levels of nitric oxide,malondialdehyde in the liver and serum enzymes were determined.RESULTS BPC 157 counteracted increased P wave amplitude,tachycardia and ST-elevation,i.e.,right heart failure from acute thrombotic coronary occlusion.The bypassing pathway of the inferior vena cava-azygos(hemiazygos)vein-superior vena cava and portocaval shunt occurred rapidly.Even with severe caval portal hypertension,BPC 157 antagonized portal and caval hypertension and aortal hypotension,and also reduced refractory ascites.Thrombosis of portal vein tributaries,inferior vena cava,and hepatic and coronary arteries was attenuated.In addition,there was reduced pathology of the lungs(severe capillary congestion)and liver(dilated central veins and terminal portal venules),decreased intestine hemorrhagic lesions(substantial capillary congestion,submucosal edema and architecture loss),and increased liver and spleen weight.During the period of ligation,nitric oxide-and malondialdehyde-levels in the liver remained within normal healthy values,and increases in serum enzymes were markedly reduced.CONCLUSION BPC 157 counteracts Budd Chiari syndrome in rats. | Slaven Gojkovic Ivan Krezic Borna Vrdoljak Dominik Malekinusic Ivan Barisic andreja Petrovic Katarina Horvat Pavlov Marijan Kolovrat Antonija Duzel Mario Knezevic Katarina Kasnik Kovac Domagoj Drmic Lovorka Batelja Vuletic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric | 2020 | World Journal of Gastrointestinal Pathophysiology2020，11，1： | 2 |
| 6 | 汞污染渔业的恢复显示文摘本文中,我们综合了有关生态系统无机汞(Hg)载荷变化与鱼体内甲基汞(MeHg)浓度之间联系的现有信息。尽管人们普遍假定水生生态系统汞载荷的增加导致鱼体内甲基汞浓度的增加,验证这一假定的定量数据尚很有限。这里,我们研究了源于一系列出处的现有证据:关于被工业排放物污染的生态系统的研究;关于鱼类甲基汞对大气载荷的响应的观测资料;跨越空间和环境梯度的研究以及实验操作。本文概述了目前对从汞载荷到鱼体甲基汞的运输和转化所涉及的主要过程的了解情况。还结合影响与鱼体内甲基汞响应的时机和大小有关的汞循环和生物积累的其他因素探讨了汞载荷的作用。所得出的主要结论是,汞载荷的变化(增加或减少)将引起鱼体内甲基汞的反应,这种反应的时间和大小将根据生态系统特有的变量和所添加的汞的形态而变化。 | John Munthe R. A. (Drew) Bodaly Brian A. Branfireun Charles T. Driscoll Cynthia C. Gilmour Reed Harris Milena Horvat Marc Lucotte Olaf Malm 林宝法(译) | 2007 | AMBIO-人类环境杂志2007，36，1： | 2 |
| 7 | Changes in nonvolatile acids, sugars, pectin and sugar composition of pectin during peach (cv Monroe) maturation显示文摘 | Chapman G W Horvat R J | 1990 | J Agric Food Chem1990，38，： | 1 |
| 8 | Immunological decision-making: how does the immune system decide to mount a helper T-cell response? 显示文摘 | Kaiko G E Horvat J C Beagley K W | 2008 | Immunology2008，123，3： | 1 |
| 9 | Differential surface plasmon resonance imaging for high-throughput bioanalyses 显示文摘 | BOECKER D ZYBIN A HORVATIC V | 2007 | Analytical Chemistry2007，79，： | 1 |
| 10 | The correlation between the frequency of micronuclei and specific chromosome aberrations in human lymphocytes exposed to microwave radiation in vitro 显示文摘 | Garaj-Vrhovac V Fucic A Horvat D | 1992 | Mutat Res1992，281，3： | 1 |
| 11 | Porewater distribution and benthic flux measurements of mercury and methylmercury in the Gulf of Trieste (Northern Adriatic Sea)显示文摘 | Covelli S Faganeli J Horvat M | 1999 | Estuarine Coastal and Shelf Science1999，48，： | 1 |
| 12 | An event-driven approach to the current control of a BLDC motor using FPGA 显示文摘 | Horvat R Jezemik K CUrkovic M | 2014 | Industrial Electronics2014，61，7： | 1 |
| 13 | Electrochemical properties of hydrous ruthenium oxide films formed and measured at different potentials显示文摘 | KVASTEK K HORVAT V | 2001 | Journal of Electroanalytical Chemistry2001，511，： | 1 |
| 14 | Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo 显示文摘 | Hu Y Cherton Horvat G Dragowska V | 2003 | Clin Cancer Res2003，9，： | 1 |
| 15 | Procalcitonin in patients with acute myocardial infarction显示文摘 | Remskar M Horvat M Hojker S | 2002 | Wien Klin Wochenschr2002，114，56： | 1 |
| 16 | An Event-drivenApproach to the Current Control of a BLDC Motor UsingFPGA显示文摘 | HORVAT R JEZERNIK K CURKOYIC M | 2014 | IEEE Transactions on Industrial Electronics2014，61，7： | 1 |
| 17 | Cross-correlations between volume change and price change 显示文摘 | Podobnik B Horvatic D Petersen A M | 2009 | Proceed- ings of the National Academy of Sciences2009，106，22： | 1 |
| 18 | Modeling dye degradation kinetic using dark-and photo-Fenton type processes 显示文摘 | Kusic H Koprivanac N Horvat S | 2009 | Chemical Engineering Journal2009，155，： | 1 |
| 19 | Total mercury, methylmercury and selenium in mercury polluted areas in the province Guizhou, China 显示文摘 | Horvat M Nolde N Fajon V | 2003 | Science of the Total Environment2003，，13： | 1 |
| 20 | Sample preparation in analysis of pharmaceuticals显示文摘 | MUTAVDZIC D BABIC S Horvat A J M | 2007 | Trends Anal Chem2007，26，11： | 1 |
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