|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 2 | On the nomenclature, classification, and abstractions of compliant mechanisms显示文摘 | MIDHA A NORTON T W HOWELL L L | 1994 | ASME J of Mechanical Design1994，116，1： | 2 |
| 3 | Limit positions of compliant mechanisms using the pseudo-rigid-body model concept显示文摘 | Midha A Howell L L Norton T W | 2000 | Mechanism and Machine Theory2000，35，： | 2 |
| 4 | Evalution ofequivalent spring stiffness for use in a pseudo--rigid-body model of large-deflection compliant mechanisms显示文摘 | HOWELL L L MIDRA A NORTON T W | 1996 | Transactions of the ASME1996，118，3： | 1 |
| 5 | The Direct Linearization Method Applied to Position Error in Kinematic Linkages显示文摘 | WITTWER J W CHASE K W HOWELL L L | 2004 | Mechanism and Machine Theory2004，39，7： | 1 |
| 6 | Tracheosto- my in Children with Emphasis on Home Care显示文摘 | Duncan W D Howell L J deLorimier A A | 1992 | Pediatr Surg1992，27，4： | 1 |
| 7 | On the nomenclature, classification, and abstractions of compliant mechanisms 显示文摘 | Midha A Norton T W Howell L L | 1994 | Journal of Mechanical Design1994，116，1： | 1 |
| 8 | The preparation of primary poly-hexafluoropropylene oxide halides (poly HFPO- CF2X where X=I, Br, C1 and F) 显示文摘 | HOWELL J L LU N PEREZ E W | 2004 | J Fluorine Chem2004，125，10： | 1 |
| 9 | Nimbus-6 Earth radiation budget experiment显示文摘 | Smith W L Hickey J Howell H B | | 0，，02： | 1 |
| 10 | On the nomenclature, classification and abstractions of compliant mechanisms 显示文摘 | MIDHA A NORTON T W HOWELL L | 1994 | Journal of Mechanical Design1994，116，1： | 1 |
| 11 | On the nomenclature, classification, and abstractions of compliant mechanisms 显示文摘 | Midha A Norton T W Howell L L | 1994 | ASME Journal of Mechanical Design1994，116，1： | 1 |
| 12 | On nomenclature, classification, and abstraction of compliant mechanisms 显示文摘 | Midha A Norton T W Howell L L | 1994 | Trans ASME d Mech Design1994，116，1： | 1 |
| 13 | On the Nomenclature, Classification, and Abstractions of Compliant Mecha- nisms显示文摘 | Midha A Norton T W Howell L L | 1994 | Journal of Mechanical Design1994，116，3： | 1 |
| 14 | Application of cap- illary electrophoresis to study the enantioselective transformation of five chiral pesticides in aerobic soil slurries 显示文摘 | JARMAN J L JONES W J HOWELL L A | 2005 | Journal of Agriculture Food Chemistry2005，53，： | 1 |
| 15 | Limit positions of compliant mechanisms using the pseudo-rigid-body model concept显示文摘 | MIDHA A HOWELL L L NORTON T W | 2000 | Mech and Mach Theory2000，35，1： | 1 |
| 16 | Evalution of Equivalent Spring Stiffness for Use in a Pseudo-rigid-body Model of Large-deflection Compliant Mechanisms显示文摘 | Howell L L Midra A Norton T W | 1996 | Transactions of the ASME1996，118，3： | 1 |
| 17 | The direct linearization method applied to position error in kine- matic linkages 显示文摘 | Wittwer J W Chase K W Howell L L | 2004 | Mechanism and Machine Theory2004，39，7： | 1 |
| 18 | Com- pliant High-precision E-quintet Rateheting Mecha- nism for Safety and Arming Devices显示文摘 | Kennedy J A Howell L L Greenwood W | 2007 | Precision Engineering2007，31，1： | 1 |
| 19 | A quantitative analysis of DNA extraction and purification from compost 显示文摘 | Howeler M Ghiorse W C Walker L P | 2003 | J Micro Methods2003，54，： | 1 |
| 20 | On the nomenclature,classification,and abstractions of fully compliant mechanisms显示文摘 | Midha A Norton T W Howell L L | 1994 | Journal of Mechanical Design1994，116，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员