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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C ZhangJ Hui A B Wong N Lau T K Leung T N | 2004 | Clin Chem2004，50，： | 1 |
| 4 | Refinery planning under uncertainty 显示文摘 | Li W K Hui C W Li P Li A X | 2004 | Industrial & Engineering Chemistry Research2004，43，21： | 1 |
| 5 | Molecular analysis of hypoxanthine phosphoribosyltransferase gene deletions induced by alpha- and X- radiation in human lymphoblastoid cells显示文摘 | Bao C Y Ma A H Evans H H Horng M F Mencl J Hui T E Sedwick W D | 1995 | Mutation Research1995，326，： | 1 |
| 6 | Adhesion, friction, and compliance of bio-mimetic and bio-inspired structured interfaces 显示文摘 | JAGOTA A HUI C Y | 2011 | Materials Science and Engineering2011，72，12： | 1 |
| 7 | Wind turbulence characteristics study at the Stonecutters Bridge site: Part I-Mean wind and turbulence intensities显示文摘 | HUI M C H LARSEN A XIANG H F | 2009 | Journal of Wind Engineering and Industrial Aerodynamics2009，97，1： | 1 |
| 8 | Cyelin D1, EMS1 and 11q13 amplification in breast cancer显示文摘 | Ormandy C J Musgrove E A Hui R | 2003 | Breast Cancer Res Treat2003，78，3： | 1 |
| 9 | Mining a web citation database for document clustering 显示文摘 | HE Y HUI S C FONG A C M | 2002 | Applied Artificial Intelligence2002，16，： | 1 |
| 10 | An improved adaptive detection methods for power quality improvement 显示文摘 | QIAN Le-wei DAVID A C LI Hui | 2008 | IEEE Transactions on Industry Applications2008，44，2： | 1 |
| 11 | Comparison of FEM and BEM for interactive object simulation显示文摘 | TANG Y M ZHON A F HUI K C | 2006 | Computer Aided Design2006，38，8： | 1 |
| 12 | An intelligent online machine fault diagnosis system 显示文摘 | Fong A C M Hui S C | 2001 | Computing & Control Engineering Journal2001，25，10： | 1 |
| 13 | Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma显示文摘 | Chan H L Hui A Y Wong M L Tse A M Hung L C Wong V W | 2004 | Gut2004，53，： | 1 |
| 14 | Day-of-the-week Effects:Evidence from Developing Stock Markets 显示文摘 | Wong K A Hui T K Chan C Y | 1992 | Applied Financial Economics1992，2，1： | 1 |
| 15 | The crystal structure of the β'phase in Al-Mg-Si alloys显示文摘 | VISSERS R van HUIS M A ZANDBERGEN H W MARIOARA C D | 2007 | Acta Mater2007，55，： | 1 |
| 16 | Hepatitis B virus genotype C takes a more aggressive disease course than hepatitis B virus genotype B in hepatitis B e antigen-positive patients显示文摘 | Chan H L Wong M L Hui A Y Hung L C Chan F K Sung J J | 2003 | J Clin Microbiol2003，41，： | 1 |
| 17 | Associative Classification with Artificial Immune System显示文摘 | Do T D Hui S C Fong A C M | 2009 | IEEE Trans on Evol Comput2009，2，13： | 1 |
| 18 | Adhesion enhancement in a biomimetic fibrillar interface显示文摘 | Glassmaker N J Jagota A Hui C Y | | 0，，04： | 1 |
| 19 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C Zhang J Hui A B | 2004 | Clin Chem2004，50，1： | 1 |
| 20 | Cyclin D1, EMS1 and 11q13 amplification in breast cancer 显示文摘 | Ormandy C J Musgrove E A Hui R | 2003 | Breast Cancer Res Treat2003，78，3： | 1 |
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