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| 1 | THE SUPERCONVERGENCE ANALYSIS OF AN ANISOTROPIC FINITE ELEMENT显示文摘这篇论文在各向异性的矩形的网孔的班上处理双线性的有限元素的高精确性分析。各向异性的网孔上的反的不平等被建立。超级结束和超级集中被获得因为第二订椭圆形的问题。数字测试被给,它与我们的理论分析与一致。 | SHI Dongyang ZHU Huiqing | 2005 | Journal of Systems Science & Complexity2005，18，4： | 32 |
| 2 | LA-ICPMS锆石U-Pb定年的准确度:多实验室对比分析显示文摘近10多年来LA-ICPMS锆石U-Pb定年技术得到迅速发展和应用,其特点是成本低、分析速度快,U-Pb定年的内部精度可以优于1%,但其外部重现性(准确度)则相对较差.为了定量评估LA-ICPMS锆石U-Pb定年的准确性,本文在多个SIMS和LA-ICPMS实验室对一个中生代闪长质暗色包体的锆石样品(FS06)和一个新元古代闪长岩的锆石样品(WC09-32)进行对比分析.三台SIMS对FS06和WC09-32锆石的U-Pb分析获得了在误差范围一致的定年结果,其最佳形成年龄分别为132.2和760.5 Ma(不确定度~1%,2RSD).6个LA-ICPMS实验室获得的FS06锆石的U-Pb年龄结果范围为(128.3±1.0)^(135.0±0.9)Ma(2SE),WC09-32锆石的U-Pb年龄结果范围为(742.9±3.1)^(777.8±4.7)Ma(2SE),外部误差达到~4%(2RSD).LA-ICPMS锆石U-Pb定年的误差来源包括单点同位素比值测定时引入的误差、用标样计算分馏因子时引入的误差、普通铅校正造成的年龄误差和标准样品推荐值的误差以及数据处理及相关软件的使用.本文的结果客观地反映了目前的LA-ICPMS分析技术对锆石U-Pb定年的不确定度水平在~4%(2RSD).因此,在对LA-ICPMS锆石U-Pb定年结果的解释和应用时,必须考虑该方法的不确定度水平. | 李献华 柳小明 刘勇胜 苏犁 孙卫东 HUANG HuiQing YI Keewook | 2015 | 中国科学:地球科学2015，45，9： | 22 |
| 3 | MicroRNAs and prostate cancer显示文摘MicroRNAs (miRNAs ) 是否定地调整基因表示由的小、非编码的、搁浅单人赛的 RNA 的一个类对在 post-transcriptional 水平的目标 mRNAs 的 3 untranslated 区域(UTR ) 主要有约束力。最近的研究证明了 miRNAs 的异常表情仔细包括前列腺癌症(PCa ) 与各种各样的癌症的发展,侵略,转移和预后被联系。位于 miRNAs 的异常表示下面的建议分子的机制源于基因变化, epigenetic 修正和 Dicer 丰富的改变。尽管多达 50 miRNAs 被报导了显著地在人的 PCa 被表示,仅仅他们的一个小数字试验性地被显示做贡献到 PCa 的致病。这评论的目的是描述几已知的 miRNAs 的机制,在 oncogenic miRNAs 的改变的表示的关联上总结最近的研究(例如 miR-221/-222 , miR-21 ,和 miR-125b )并且肿瘤 suppressor miRNAs (例如 miR-101 , miR-126 *, miR-146a , miR-330 , miR-34 簇,并且 miR-200 家庭)为 PCa 。另外,他们在 PCa 的潜在的临床的应用和前景例如 biomarkers 和临床的治疗,简短也被讨论。 | Yingxin Pang Charles Y.F. Young Huiqing Yuan | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 15 |
| 4 | Accuracy of LA-ICPMS zircon U-Pb age determination:An inter-laboratory comparison显示文摘LA-ICPMS zircon U-Pb dating has been greatly advanced and widely applied in the past decade because it is a cheap and fast technique.The internal error of LA-ICPMS zircon U-Pb dating can be better than 1%,but reproducibility(accuracy)is relatively poor.In order to quantitatively assess the accuracy of this technique,zircons from two dioritic rocks,a Mesozoic dioritic microgranular enclave(FS06)and a Neoproterozoic diorite(WC09-32),were dated independently in eight laboratories using SIMS and LA-ICPMS.Results of three SIMS analyses on FS06 and WC09-2 are indistinguishable within error and give a best estimate of the crystallization age of 132.2 and 760.5 Ma(reproducibility is^1%,2RSD),respectively.Zircon U-Pb ages determined by LA-ICPMS in six laboratories vary from 128.3±1.0 to 135.0±0.9 Ma(2SE)for FS06 and from 742.9±3.1 to777.8±4.7 Ma(2SE)for WC09-32,suggesting a reproducibility of^4%(2RSD).Uncertainty produced during LA-ICPMS zircon U-Pb analyses comes from multiple sources,including uncertainty in the isotopic ratio measurements,uncertainty in the fractionation factor calculation using an external standard,uncertainty in the age determination as a result of common lead correction,age uncertainty of the external standards and uncertainty in the data reduction.Result of our study suggests that the uncertainty of LA-ICPMS zircon U-Pb dating is approximately 4%(2RSD).The uncertainty in age determination must be considered in order to interpret LA-ICPMS zircon U-Pb data rationally. | LI XianHua LIU XiaoMing LIU YongSheng SU Li SUN WeiDong HUANG HuiQing YI Keewook | 2015 | Science China Earth Sciences2015，58，10： | 15 |
| 5 | In Vitro Probiotic Effect of Pseudostellaria heterophylla Fibrous Roots on Feed Bacillus subtilis and Preliminary Study on Its Solid Fermentation显示文摘Traditional Chinese medicine Pseudostellaria heterophylla fibrous roots have been widely studied and applied in non-antibiotic clinical breeding of livestock and poultry. In vitro probiotic effect of P. heterophylla fibrous roots extract on feed probiotics Bacillus subtilis BD-K010 was studied, and the feasibility of solid fermentation of P. heterophylla fibrous roots was preliminarily evaluated. For in vitro probiotic effect, the increased concentration of P. heterophylla fibrous roots extract dependently increased the total biomass of B. subtilis BD-K010;1.0% P. heterophylla fibrous roots extract received the best effect, and the final p H of 1.0% experimental group was closer to neutral. Meantime, B. subtilis BD-K010 with optimum concentration of P. heterophylla fibrous roots showed significantly higher in vitro antibacterial effect than the control group(P<0.01),and the antibacterial effects on Escherichia coli and Staphylococcus aureus were improved by 51.99% and 63.16%, but it was ineffective to Salmonella. For solid fermentation, the profile of substrate complex and appendage flocculent structure on substrate surface at the end of fermenta-tion in experimental groups added with B. subtilis BD-K010 and cellulase plus BD-K010 were more complex;the live bacteria number, polysaccharide content and saponin content at fermentation end-point in two experimental groups were extremely higher than those in the control group(P<0.01).P. heterophylla fibrous roots extract had good in vitro probiotic effect on B. subtilis BD-K010 and promoted its antibacterial effect, and it is feasible to use probiotics for solid fermentation of P. heterophylla fibrous roots and to improve effective components. It is of great significance to further de-velop and utilize P. heterophylla fibrous roots resources in modern animal husbandry. | Pan Huiqing Zhang Yanda Li Zhujin Zhao Qi | 2019 | Animal Husbandry and Feed Science2019，11，2： | 14 |
| 6 | Effects of resolvin D1 on inflammatory responses and oxidative stress of lipopolysaccharide-induced acute lung injury in mice显示文摘 | Yuan Ruixia Wang Lei Yao Chengyue Wu Qingping Marie Christelle Xie Wanli Zhang Xingcai Sun Wei Wang Huiqing Yao Shanglong | 2014 | Chinese Medical Journal2014，，5： | 10 |
| 7 | Observation and modeling of NPP for Pinus elliottii plantation in subtropical China显示文摘Based on the stem analysis of 59 individuals of Pinus elliottii in combination with tree biomass models, we calculated annual biomass increment of forest plots at Qianyanzhou Ecological Station, Chinese Academy of Sciences in subtropical China. In addition, canopy layer and community NPP were calcu- lated based on 12 years’ litter fall data. NPP of the 21-year-old forest was estimated by using the BIOME BGC model; and both measured NPP and estimated NPP were compared with flux data. Community biomass was 10574 g·m-2; its distribution patterns in tree layer, shrub layer, herbaceous layer, tree root, herbaceous and shrub roots and fine roots were 7542, 480, 239, 1810, 230, 274 and 239 g·m-2, respectively. From 1999 to 2004, the average annual growth rate and litter fall were 741 g·m-2·a-1 (381.31 gC·m-2·a-1) and 849 g·m?2·a?1 (463 gC·m-2·a-1), respectively. There was a significant corre- lation between annual litter fall and annual biomass increment; and the litter fall was 1.19 times the biomass increment of living trees. From 1985 to 2005, average NPP and GPP values based on BGC modeling were 630.88 (343.31 - 906.42 gC·m-2·a-1) and 1 800 gC·m-2·a-1 (1351.62 - 2318.26 gC·m-2·a-1). Regression analysis showed a linear relationship (R2=0.48) between the measured and simulated tree layer NPP values. NPP accounted for 30.2% (25.6%-32.9%) of GPP, while NEP ac- counted for 57.5% (48.1%-66.5%) of tree-layer NPP and 41.74% (37%-52%) of stand NPP. Soil respi- ration accounted for 77.0% of measured tree NPP and 55.9% of the measured stand NPP. NEE based on eddy covariance method was 12.97% higher than the observed NEP. | MA ZeQing LIU QiJing WANG HuiMin LI XuanRan ZENG HuiQing XU WenJia | 2008 | Science China Earth Sciences2008，51，7： | 9 |
| 8 | Adaptive perturb and observe maximum power point tracking with current predictive and decoupled power control for gridconnected photovoltaic inverters显示文摘In order to improve maximum power point tracking(MPPT) performance, a variable and adaptive perturb and observe(P&O)method with current predictive control is proposed. This is applied in three-phase threelevel neutral-point clamped(NPC) photovoltaic(PV)generation systems. To control the active power and the reactive power independently,the decoupled power control combined with a space vector modulation block is adopted for three-phase NPC inverters in PV generation systems.To balance the neutral-point voltage of the three-phase NPC grid-connected inverter, a proportional and integral control is used by adj usting the dwell time of small voltage vectors. A three-phase NPC inverter rated at 12 kVA was established. The performance of the proposed method was tested and compared with the fixed perturbation MPPT algorithm under different conditions. Experimental results confirm the feasibility and advantages of the proposed method. | Yong YANG Huiqing WEN | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，2： | 8 |
| 9 | Clinical characterization and diagnosis of cystic fibrosis throughexome sequencing in Chinese infants with Bartter-syndrome-like hypokalemia alkalosis显示文摘Cystic fibrosis (CF) is a fatal autosomal-recessive disease caused by mutations in the CFtransmembrane conductance regulator (CFTR) gene. CF is characterized by recurrent pulmonary infectionwith obstructive pulmonary disease. CF is common in the Caucasian population but is rare in the Chinesepopulation. The symptoms of early-stage CF are often untypical and may sometimes manifest as Bartter syndrome(BS)-like hypokalemic alkalosis. Therefore, the ability of doctors to differentiate CF from BS-like hypokalemicalkalosis in Chinese infants is a great challenge in the timely and accurate diagnosis of CF. In China, sporadic CFhas not been diagnosed in children younger than three years of age to date. Three infants, who were initiallyadmitted to our hospital over the period of June 2013 to September 2014 with BS-like hypokalemic alkalosis, werediagnosed with CF through exome sequencing and sweat chloride measurement. The compound heterozygousmutations of the CFTR gene were detected in two infants, and a homozygous missense mutation was found in oneinfant. Among the six identified mutations, two are novel point mutations (c.1526G 〉 C and c.3062C 〉 T) that arepossibly pathogenic. The three infants are the youngest Chinese patients to have been diagnosed with sporadic CFat a very early stage. Follow-up examination showed that all of the cases remained symptom-free after earlyintervention, indicating the potential benefit of very early diagnosis and timely intervention in children with CF.Our results demonstrate the necessity of distinguishing CF from BS in Chinese infants with hypokalemic alkalosisand the significant diagnostic value of powerful exome sequencing for rare genetic diseases. Furthermore, ourfindings expand the CFTR mutation spectrum associated with CF. | Liru Qiu Fengjie Yang Yonghua He Huiqing Yuan Jianhua Zhou | 2018 | Frontiers of Medicine2018，12，5： | 7 |
| 10 | NUMERICAL SIMULATION FOR A PROCESS ANALYSIS OF A COKE OVEN显示文摘A computational fluid dynamic model is established for a coking process analysis of a coke oven using PHOENICS CFD package. The model simultaneously calculates the transient composition, temperatures of the gas and the solid phases, velocity of the gas phase and porosity and density of the semi-coke phase. Numerical simulation is illustrated in predicting the evolution of volatile gases, gas flow paths, profiles of density, porosity of the coke oven charge,profiles of temperatures of the coke oven gas and the semi-coke bed. On the basis of above modeling, the flow of coke oven gas (COG) blown from the bottom of the coke oven into the porous semi-coke bed is simulated to reveal whether or not and when the blown COG can uniformly flow through the porous semi-coke bed for the purpose of desulfurizing the semi-coke by recycling the COG. The simulation results show that the blown COG can uniformly flow through the semi-coke bed only after the temperature at the center of the semi-coke bed has risen to above 900 ℃. | Zhancheng Guo Huiqing Tang | 2005 | China Particuology2005，3，6： | 7 |
| 11 | Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle显示文摘mRNA is a novel class of therapeutic modality that holds great promise in vaccination,protein replacement therapy,cancer immunotherapy,immune cell engineering etc.However,optimization of mRNA molecules and efficient in vivo delivery are quite important but challenging for its broad application.Here we present an ionizable lipid nanoparticle(iLNP)based on iBL0713 lipid for in vitro and in vivo expression of desired proteins using codon-optimized mRNAs.mRNAs encoding luciferase or erythropoietin(EPO)were prepared by in vitro transcription and formulated with proposed iLNP,to form iLP171/mRNA formulations.It was revealed that both luciferase and EPO proteins were successfully expressed by human hepatocellular carcinoma cells and hepatocytes.The maximum amount of protein expression was found at 6 h post-administration.The expression efficiency of EPO with codon-optimized mRNA was significantly higher than that of unoptimized mRNA.Moreover,no toxicity or immunogenicity was observed for these mRNA formulations.Therefore,our study provides a useful and promising platform for mRNA therapeutic development. | Tongren Yang Chunhui Li Xiaoxia Wang Deyao Zhao Mengjie Zhang Huiqing Cao Zicai Liang Haihua Xiao Xing-Jie Liang Yuhua Weng Yuanyu Huang | 2020 | Bioactive Materials2020，5，4： | 7 |
| 12 | Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway显示文摘OBJECTIVE: To investigate the effect of Banxia Xiexin decoction(BXD) on Helicobacter pylori(Hp)-related peptic ulcers(PUs) and the possible mecha-nism underlying BXD actions via the transforming growth factor-β/small mothers against decapentaplegic(TGF-β/Smad) signaling pathway.METHODS: PU patients with cold-heat complex syndrome were randomly assigned to groups that received Chinese or Western medicines with 20 patients in each group. Serum was collected after 7 d of treatment. The healthy group included 20 individuals. Gastric mucosal epithelial cell line GES-1 was cultured in vitro and randomly divided into the following seven groups: control, model, healthy,Western Medicine, prior treatment, low dosage,and high dosage. After 72 h of treatment with the corresponding serum, the m RNA and protein expression levels of TGF-β1, Smad3, and Smad7 were measured by reverse transcription quantitative polymerase chain reaction and western blotting, respectively.RESULTS: The m RNA expression levels of TGF-β1 and Smad3 in GES-1 cells were increased after Hp introduction, and these increased levels were reduced by the BXD-containing serum. The protein levels of p-Smad3, but not TGF-β1 or Smad3, were significantly increased in Hp-treated GES-1 cells,and treatment with the BXD-containing serum markedly decreased the protein levels. Smad7 expression was significantly enhanced following treatment with the BXD-containing serum at transcriptional and protein levels in a dose-dependent manner.CONCLUSION: BXD regulates the TGF-β/Smad signaling pathway by inhibiting the expression of TGF-β1 and Smad3, and increasing the expression of Smad7. | Chen Shaofang Liang Huiqing Chen Shaodong Huang Yanping Wan Shichuan Huang Yanxia | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 7 |
| 13 | Characteristics of volatile compounds removal in biogas slurry of pig manure by ozone oxidation and organic solvents extraction显示文摘Biogas slurry is not suitable for liquid fertilizer due to its high amounts of volatile materials being of complicated composition and peculiar smell. In order to remove volatiles from biogas slurry efficiently, the dynamic headspace and gas chromatography-mass spectrometry were used to clear the composition of volatiles. Nitrogen stripping and superfluous ozone were also used to remove volatiles from biogas slurry. The results showed that there were 21 kinds of volatile compounds in the biogas slurry, including sulfur compounds, organic amines, benzene, halogen generation of hydrocarbons and alkanes, some of which had strong peculiar smell. The volatile compounds in biogas slurry can be removed with the rate of 53.0% by nitrogen stripping and with rate of 81.7% by the oxidization and stripping of the superfluous ozone. On this basis, the removal rate of the volatile compounds reached 99.2% by chloroform and n-hexane extraction, and almost all of odor was eliminated. The contents of some dissolved organic compounds decreased obviously and however main plant nutrients had no significant change in the biogas slurry after being treated. | Yujun Wang Lianshuang Feng Xiaosong Zhao Xiulan Ma Jingmin Yang Huiqing Liu Sen Dou Miping Zhou Zhonglei Xie | 2013 | Journal of Environmental Sciences2013，25，9： | 7 |
| 14 | Controlled preparation of P-doped g-C3N4 nanosheets for efficient photocatalytic hydrogen production显示文摘Hydrogen production by photolysis of water by sunlight is an environmentally-friendly preparation technology for renewable energy.Graphitic carbon nitride(g-C3N4),despite with obvious catalytic effect,is still unsatisfactory for hydrogen production.In this work,phosphorus element is incorporated to tune g-C3N4's property through calcinating the mixture of g-C3N4 and Na H2PO2,sacrificial agent and co-catalyst also been supplied to help efficient photocatalytic hydrogen production.Phosphorus(P)doped g-C3N4 samples(PCN-S)were prepared,and their catalytic properties were studied.X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM)and ultraviolet diffuse reflection(UV-DRS)were used to study their structures and morphologies.The results show that the reaction rate of PCN-S is 318μmol·h^-1·g^-1,which is 2.98 times as high as pure carbon nitride nanosheets(CN)can do.Our study paves a new avenue,which is simple,environment-friendly and sustainable,to synthesize highly efficient P doping g-C3N4 nanosheets for solar energy conversion. | Qiachun Lin Zesheng Li Tingjian Lin Bolin Li Xichun Liao Huiqing Yu Changlin Yu | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 6 |
| 15 | Optimization of dosage ratio of chlorogenic acid and gardenia glycosides in the treatment of rats with fatty liver disease induced by high-fat feed显示文摘OBJECTIVE: To investigate the optimal dosage ratio of chlorogenic acid and gardenia glycosides in treating the rates with fatty liver disease induced by high-fat feed.METHODS: A rat model of non-alcoholic fatty liver disease(NAFLD) was established by using a high-fat diet. According to mathematical model 'uniform design', varying doses of chlorogenic acid and gardenia glycosides have been combined to form 6 medications for the treatment of NAFLD.Samples were then taken to observe pathological changes of the liver tissue(HE staining); changes in the fat metabolism pathway e.g. triglyceride(TG)and free fatty acid(FFA) content; alterations in liver function, i.e. serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST) activity; and differences in Malondialdehyde(MDA) and superoxide dismutase(SOD) content in the liver tissue. Multiple regression analysis was conducted to test the optimal dosage ratio of chlorogenic acid and gardenia glycosides.RESULTS: Fatty degeneration and vacuole-like changes of different degrees occurred in hepatic cells of the model group. Markers for fat metabolism, serum ALT and AST activities, and expression of MDA in liver tissue significantly increased, while SOD decreased. Combination of 90 mg chlorogenic acid and 90 mg Gardenia glycosides was the optimal dosage ratio of chlorogenic acid and gardenia glycosides in the treatment of rats with fatty liver induced by high-fat diet.CONCLUSION: Chlorogenic acid of 90 mg plus gardenia glycosides of 90 mg was the best combination in the treatment of fatty liver disease in rats induced by high-fat feed. | Liang Huiqing Yang Jiaen Tang Jinmo Wu Chuncheng Li Hongshan Chen Shaodong | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 6 |
| 16 | Research on Mechanisms of Steam Breakthrough and Profile Control Design for Steam Soaking Well显示文摘Scaled physical model tests for steam breakthrough were conducted based on the analysis of mechanisms and influence factors of steam breakthrough. Physical simulation results showed that at the initial steam breakthrough, preferential flow channels were formed in narrow sand packs and most residual oil left in these channels was immobile. This shortened the steam breakthrough time of follow-up steam flooding and decreased the increment of oil recovery efficiency. Steam breakthrough occurred easily for a smaller producer-injector spacing, and a bigger difference in physical properties between fluids and rock. Steam breakthrough is more likely to occur at a larger formation permeability (k), greater steam displacement velocity (u) and smaller producer-injector spacing (L). Steam breakthrough time is a function of the parameter group (uk/L), i.e. tb=3.2151 (uk/L) -0.5142. A non piston-like displacement model was built based on steam breakthrough observation for a steam stimulated well in the Jinglou Oilfield, Henan Oilfield Company. The steam volume swept in different directions could be obtained from inter-well permeability capacity and breakthrough angle, and the steam swept pore volume (SSPV) was also determined. Numerical simulation showed that steam sweep efficiency reached its peak value when a slug of profile control agent (slug size 10%-15% SSPV) was set at one half of the inter-well spacing. Field test with 12.5% SSPV of profile control agents in the Jinglou Oilfield achieved success in sealing breakthrough channels and good production performance of adjacent producers. | Liu Huiqing Zhang Hongling Wang Shulin Wang Han Bao Shucheng | 2006 | Petroleum Science2006，3，3： | 5 |
| 17 | Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates显示文摘MyD88 独立的小径,发信号的二关键 TLR 之一发送,被认为是脊椎动物革新。然而,一个新奇 Toll/interleukin-1 受体(TIR ) 适配器,指明的 bbtTICAM,在基础脊索动物文昌鱼被识别,连接这条小径到无脊椎动物。bbtTICAM 的蛋白质建筑学类似于脊椎动物 TICAM1 的(包含 TIR 适配器 molecule-1,也作为 TRIF 知道) 当种系发生的分析基于 TIR 领域显示了那时, bbtTICAM 是脊椎动物 TICAM1 和 TICAM2 的最旧的 ortholog (包含 TIR 适配器 molecule-2,是也知道电车) 。类似于人的 TICAM1, bbtTICAM 激活 NF-κ以由与受体交往蛋白质交往的一种 MyD88 独立的方式的 B (裂开) 经由它的 RHIM 主题。如此的激活要求 bbtTICAM 形成 homodimers 在里面内涵体,和它可以被文昌鱼 SARM 否定地调整(无菌的 α并且犰狳包含主题的蛋白质) 并且 TRAF2。然而, bbtTICAM 没导致类型的生产我干扰素。因此,我们的学习不仅介绍脊椎动物 TICAM1 和 TICAM2 的祖先的特征,而且从基础脊索动物揭示 MyD88 独立的小径的进化起源,它将帮助理解脊椎动物 TLR 网络的开发。 | Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu | 2011 | Cell Research2011，21，10： | 5 |
| 18 | Inactivation of TFEB and NF-kB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion显示文摘It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy. | Huanmin Niu Lilin Qian Bin Sun Wenjian Liu Fang Wang Qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa Hongxiang Lou Huiqing Yuan | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 4 |
| 19 | Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness显示文摘A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions.However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections(ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls.Prediction of the patients' outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level. | Ping Chen Qiuyou Xie Xiaoyan Wu Huiyuan Huang Wei Lv Lixiang Chen Yequn Guo Shufei Zhang Huiqing Hu You Wang Yangang Nie Ronghao Yu Ruiwang Huang | 2018 | Neuroscience Bulletin2018，34，4： | 4 |
| 20 | Influence of Fabrication Parameters on the Phase Formation and Dielectric Properties of CaCu_3Ti_4O_(12 )Ceramics显示文摘The giant dielectric permittivity materials CaCu 3 Ti 4 O 12(CCTO) were synthesized by conventional solid-state reaction techniques.X-ray diffraction and Raman scattering for the powder indicate that the powder calcined at 950 C for 12 h has been completely transformed into the purer CCTO phase.Furthermore,the morphology and size of the grains of the ceramics sintered at 1090 C in the dwell time range from 0 to 26 h were observed by scanning electron microscopy(SEM).Dielectric properties of the polycrystalline CCTO ceramics were characterized in a broad frequency range(100 Hz-1 MHz) and at a temperature ranged from 300 to 500 K.The longer sintering time may lead to more defect structures and the enhanced conductivity,also leads to substantial improvements in permittivity.Grain size and density differences were not large enough to account for the enhancement in dielectric permittivity.Based on the observations,it is believed that the primary factor affecting dielectric behavior is the development of internal defects.The CCTO ceramics sintered at 1090 C for 15 h exhibit lower dielectric loss(~0.05) near room temperature,and the dielectric relaxation behavior above 1 kHz was observed to follow the Arrhenius law.The activation energy(E a) of 0.65 eV indicates that the doubly ionized oxygen vacancies in the grain boundaries are responsible for the dielectric relaxation of the CCTO ceramics. | Qian Zheng Huiqing Fan | 2012 | Journal of Materials Science & Technology2012，28，10： | 4 |
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