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| 1 | Numerical simulation of mechanisms of deformation,failure and energy dissipation in porous rock media subjected to wave stresses显示文摘The pore characteristics,mineral compositions,physical and mechanical properties of the subarkose sandstones were acquired by means of CT scan,X-ray diffraction and physical tests.A few physical models possessing the same pore characteristics and matrix properties but different porosities compared to the natural sandstones were developed.The 3D finite element models of the rock media with varied porosities were established based on the CT image processing of the physical models and the MIMICS software platform.The failure processes of the porous rock media loaded by the split Hopkinson pressure bar(SHPB) were simulated by satisfying the elastic wave propagation theory.The dynamic responses,stress transition,deformation and failure mechanisms of the porous rock media subjected to the wave stresses were analyzed.It is shown that an explicit and quantitative analysis of the stress,strain and deformation and failure mechanisms of porous rocks under the wave stresses can be achieved by using the developed 3D finite element models.With applied wave stresses of certain amplitude and velocity,no evident pore deformation was observed for the rock media with a porosity less than 15%.The deformation is dominantly the combination of microplasticity(shear strain),cracking(tensile strain) of matrix and coalescence of the cracked regions around pores.Shear stresses lead to microplasticity,while tensile stresses result in cracking of the matrix.Cracking and coalescence of the matrix elements in the neighborhood of pores resulted from the high transverse tensile stress or tensile strain which exceeded the threshold values.The simulation results of stress wave propagation,deformation and failure mechanisms and energy dissipation in porous rock media were in good agreement with the physical tests.The present study provides a reference for analyzing the intrinsic mechanisms of the complex dynamic response,stress transit mode,deformation and failure mechanisms and the disaster mechanisms of rock media. | JU Yang1,2,WANG HuiJie1,YANG YongMing1,HU QinAng3 & PENG RuiDong1 1 State Key Laboratory of Coal Resources and Safe Mining,Beijing Key Laboratory of Fracture and Damage Mechanics of Rock and Concrete,China University of Mining and Technology,Beijing 100083,China 2 Department of Mechanical and Manufacturing Engineering,University of Calgary,Calgary,Alberta,T2N 1N4,Canada 3 School of Environment and Civil Engineering,College of Engineering,Oklahoma State University,Stillwater,OK 74078,USA | 2010 | Science China(Technological Sciences)2010，53，4： | 32 |
| 2 | Analysis of sea surface temperature fronts in the Taiwan Strait and its adjacent area using an advanced edge detection method显示文摘A morphology-based edge detection method has been used to study sea surface temperature (SST) fronts in the Taiwan Strait and its adjacent area. The method is based on mathematical morphology with multi-dimensional and multi-structural elements. Using six years’ SST data from September 2002 to August 2008, we distinguished the large SST front like Kuroshio Front as well as the smaller ones: namely Taiwan Bank Front, Zhe-Min Coastal Front and Zhang-Yun Ridge Front. The seasonal and monthly variations of these fronts were also studied. Generally, the SST fronts are stronger in winter but weaker in summer. And the fronts are at their active stage during the period from January to May but at their declining stage during the period from July to October. | PI QingLing1,2,3 & HU JianYu1,2 1 State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China 2 Department of Oceanography, Xiamen University, Xiamen 361005, China 3 China Communications Construction Company First Harbor Consultants CO., LTD., Tianjin 300222, China | 2010 | Science China Earth Sciences2010，53，7： | 29 |
| 3 | Geochemistry of the high-Mg andesites at Zhangwu, western Liaoning: Implication for delamination of newly formed lower crust显示文摘Ten volcanic samples at Zhangwu,western Liaoning Province,North China were selected for a sys-tematic geochemical,mineralogical and geochronological study,which provides an opportunity to ex-plore the interaction between the continental crust and mantle beneath the north margin of the North China craton.Except one basalt sample(SiO2= 50.23%),the other nine samples are andesitic with SiO2 contents ranging from 53% to 59%.They have relatively high MgO(3.4%―6.1%,Mg#=50―64) and Ni and Cr contents(Ni 27×10?6―197×10?6,Cr 51×10?6―478×10?6).Other geochemical characteristics of Zhangwu high-Mg andesites(HMAs) include strong fractionation of light rare earth elements(LREE) from heavy rare earth elements(HREE),and Sr from Y,with La/Yb greater than 15,and high Sr/Y(34― 115).Zircons of andesite YX270 yield three age groups with no Precambrian age,which precludes ori-gin of the Zhangwu HMAs from the partial melting of the Precambrian crust.The oldest age group peaking at 253 Ma is interpreted to represent the collision of the Siberia block and the North China block,resulting in formation of the Central Asian orogenic belt by closure of the Mongol-Okhotsk Ocean.The intermediate age group corresponds to the basalt underplating which caused the wide-spread coeval granitoids in the North China craton with a peak 206Pb/238U age of 172 Ma.The youngest age group gives a 206Pb/238U age of 126±2 Ma,which is interpreted as the eruption age of the Zhangwu HMAs.The high 87Sr/86Sri(126 Ma)>0.706 and low εNd(t)= ?6.36―?13.99 of the Zhangwu HMAs are distinct from slab melts.The common presence of reversely zoned clinopyroxene phenocrysts in the Zhangwu HMAs argues against the origin of the Zhangwu HMAs either from melting of the water saturated mantle or melting of the lower crust.In light of the evidence mentioned above,the envisaged scenario for the formation of the Zhangwu HMAs is related to the basaltic underplating at the base of the crust,which led to the thickening of the lower crust and formation of lower crustal eclogite,followed by foundering of the eclogitic lower crust into the asthenosphere.The foundered eclogite then melted and the resul-tant melts interacted with surrounding peridotite during their upward transport,which finally produced the high-Mg andesites.This well explains the high-Mg adakitic characters and absence of ancient in-herited zircon in the Zhangwu lavas. | HUANG Hua1,GAO Shan1,2,HU ZhaoChu1,LIU XiaoMing2 & YUAN HongLing2 1 State Key Laboratory of Geological Processes and Mineral Resources,China University of Geosciences,Wuhan 430074,China 2 State Key Laboratory of Continental Dynamics,Department of Geology,Northwest University,Xi’an 710069,China | 2007 | Science China Earth Sciences2007，50，12： | 20 |
| 4 | Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China显示文摘AIM To study the relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhebitants of China, which is a unique Littoral high-risk area of esophageal carcinoma in China. The poor communication and transportation in the psst has made Cheoshan a relatively closed area and kept its culture and costure of old China thousend years ago.``METHODS Data on age, sex, ABO blood type and X-rayor psthological diagnose of the pstients with carcinoma of esophagus or cardia were collected from the Tumor Hospital. First Affiliated Hospital, Second Affiliated Hospital of Shantou University Medical College; and the Central Hospital of Shantou and the Central Hospital of Jieyang. A total of 6685 pstients with esophageal carcinoma (EC) and 2 955 patients with cardiac cancer (CC) in Chaoshen district were retrospectively assessed for their association with ABO blood groups.``RESULTS The distribution of ABO blood groups in patients with EC or CC was similar to the norrnal local population in Chaoshen. However, blood group B in male patients with CC and in the pstients with carcinoma in the upper third esophagus was 2.3% and 4.7% higher than the corresponding controls. The relative risk B: O was 1. 1415 (P<0.05)and 1 .2696 (P<0.05), respectively. No relationship was found between ABO blood groups and tumor differentiation.``CONCLTUSION ABO blood group B is associated with the incidence of CC in male individuals and carcinona in the upper third esophagus. The distribution of ABO blood groups varies in the different geographical and ethnic groups. As a result, proper controls are very important for such studies. | Min Su~1 Shan-Ming Lu~1 Dong-Ping Tian~1 Hu Zhao~1 Xiao-Yun Li~2 De-Rui Li~3 Zhi-Chao Zheng~4 1 Department of Pathology,2 Tumor Hospital,3,4 Second Teaching Hospital,Shantou University Medical College,Shantou 515031,China | 2001 | World Journal of Gastroenterology2001，7，5： | 20 |
| 5 | Preliminary study on the origin identification of natural gas by the parameters of light hydrocarbon显示文摘The light hydrocarbon composition of 209 natural gas samples and individual light hydrocarbon carbon isotopes of 53 natural gas samples from typical humic-sourced gas and sapropelic-sourced gas in the four basins of China have been determined and analyzed.Some identification parameters for humic-sourced gas and sapropelic-sourced gas are proposed or corrected.The differences of compound-specificδ13C value of individual light hydrocarbon between humic-sourced gas and sapropelic-sourced gas have been founded.The humic-sourced gas has the distribution ofδ13C benzene > -24‰,δ13C toluene >-23‰,δ13C cyclohexane >-24‰andδ13C methyl cyclohexane >-24‰,while the sapropelicsourced gas has the distribution ofδ13C benzene <-24‰,δ13C toluene <-24‰,δ13C cyclohexane <-24‰and δ13C methyl cyclohexane <-24‰.Among the components of C7 light hydrocarbon compound,such as normal heptane(nC7),methyl cyclohexane(MCH)and dimethyl cyclopentane(ΣDMCP),etc,relative contents of nC7 and MCH are influenced mainly by the source organic matter type of natural gas.Therefore,it is suggested that the gas with relative content of nC7 of more than 30%and relative content of MCH of less than 70%is sapropelic-sourced gas,while gas with relative content of nC7 of less than 35%and relative content of MCH of more than 50%is humic-sourced gas.Among components of C5-7 aliphatics, the gas with relative content of C5-7 normal alkane of more than 30%is sapropelic-sourced gas,while the gas with relative content of C5-7 normal alkane of less than 30%is humic-sourced gas.These paremeters have been suggested to identify humic-sourced gas and sapropelic-sourced gas. | HU GuoYi 1,2,3 ,LI Jian 1,2 ,LI Jin 1,2 ,LI ZhiSheng 1,2 ,LUO Xia 1,2 ,SUN QingWu 1,2 &MA ChengHua 1,2 1 Research Institute of Petroleum Exploration and Development(Langfang Branch),Petrochina,Langfang 065007,China 2 The Key Laboratory of Gas Formation and Development,Petrochina,Langfang 065007,China 3 College of Geo-Resources and Information,China University of Petroleum,Beijing 102200,China | 2008 | Science China Earth Sciences2008，51，S1： | 19 |
| 6 | The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice显示文摘INTRODUCTIONHepatitis B virus (HBV) is regarded as one of themain etiologic factors involved in the developmentof human hepatocellular carcinoma (HCC).The open reading frame (orf)of X gene of HBVencoded a transactivating factor is the evidence thatstrongly supported the notion that the X gene ofHBV DNA integrated in HCC genomic DNA couldcontribute to the carcinogenesis of liver cells byactivation of some related cellular genes | Yi Ping Hu~1 Yu Cheng Yao~1 Jian Xiu Li~1 Xin Min Wang~1 Hong Li~2 Zhong Hua Wang~1 Zhang Heng Lei~3 1 Department of Cell Biology,Second Military Medical University,Shanghai 200433,China 2 Department of Biology,Department of Basic Medicine,West-China University of Medical Sciences,Chengdu 610041,China 3 Department of Biology,North Sichuan Medical College,Nanchong 637007,China | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 7 | Orbit determination and prediction accuracy analysis for a regional tracking network显示文摘China's COMPASS satellite navigation system relies on a regional tracking network to provide navigation services. Limited by its geographic border,the regional network is able to cover only 30% of the medium-earth-orbits(MEO). Accuracy of determined and predicted orbits is not able to satisfy system requirements if the tracking data processing strategy for global tracking network processing is used for the regional network. Two major error sources for orbital prediction are accuracy of initial orbital elements and dynamical modeling. To achieve better prediction accuracy,we propose a two-step orbit determination and prediction strategy. For step 1,only solar radiation pressure(SRP) parameters are estimated along with the orbital elements and other parameters; for step 2,all parameters are estimated but the SRP parameters are tightly constrained to their step 1 estimates. Experimenting with data from a regional GPS network,we conclude for orbital prediction using the proposed two-step strategy,the average user range error(URE) for 24-h prediction arcs is better than 0.6 m. | ZHOU ShanShi 1,2,3 ,HU XiaoGong 1 & WU Bin 1 1 Shanghai Astronomical Observatory,Chinese Academy of Sciences,Shanghai 200030,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 Research Center of GNSS,Wuhan 430079,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 16 |
| 8 | Copper-chelating therapeutic effect in Wilson disease with different clinical phenotypes and polymorphisms of ATP7B gene显示文摘CopperchelatingtherapeuticefectinWilsondiseasewithdiferentclinicalphenotypesandpolymorphismsofATP7BgeneRENMingShan1,HUWen?.. | REN MingShan1, HU WenBin1, ZHANG Zhi1, JU ShuangWu1, FAN YuXin2, WANG GongQiang1 and YANG RenMin1Keywords Wilson disease/therapy copper chelating agents ATP7B gene mutations | 1998 | World Journal of Gastroenterology1998，4，4： | 15 |
| 9 | Mn content of reservoir calcite cement: A novel inorganic geotracer of secondary petroleum migration in the tectonically complex Junggar Basin (NW China)显示文摘Electronic probe microanalysis(EPMA) results of reservoir calcite cement from fourteen core samples in the Junggar Basin show that Mn-content varies largely between different samples from below the detect limitation to 4.14%,while it displays a generally good correlation with oil-gas shows.This,therefore,likely indicates that concentration of the Mn-content of the calcite cement has a close rela-tion to the intensity of petroleum fluid charging during hydrocarbon secondary migration.In order to assess this hypothesis,oxygen and strontium isotopic measurements on sixteen calcite veins host in source sequences were carried out to investigate the feature of the oil-source petroleum fluid.Analytical results imply that during hydrocarbon generation and migration,deep hot fluid has dissolved volcanic minerals interlined between mudstone source rocks.As Mn is a kind of typical trace element enriched in volcanic rocks,it is reasonable to conclude that the petroleum fluid formed in the source sequences would be Mn-rich.Consequently,calcite cements precipitated from such Mn-rich petroleum fluid would be Mn-rich accordingly.Due to the geologic chromatographic effect during migration along reservoir rocks,the decreasing of the Mn-content of the reservoir calcite cements indicates the migration direction.Then,this novel geotracer was further successfully applied in the study of hydrocarbon migration in the Junggar Basin in combination with organic geochemical analyses during the hydrocarbon migration.The Mn content of the reservoir calcite cement appears promising as a novel inorganic geotracer for the petroleum migration.This paper represents a search for novel indicators of secondary petroleum migration in tectonically complex basins based on fundamentals of the reservoir fluid-rock interactions. | CAO Jian1,HU WenXuan1,YAO SuPing1,ZHANG YiJie2,WANG XuLong3,ZHANG YueQian3,TANG Yong3 & SHI XinPu3 1 State Key Laboratory for Mineral Deposit Research,Department of Earth Sciences,Nanjing University,Nanjing 210093,China 2 Research Institute of Exploration and Development,PetroChina,Beijing 100083,China 3 Research Institute of Exploration and Development,PetroChina Xinjiang Oilfield Company,Karamay 834000,China | 2007 | Science China Earth Sciences2007，50，12： | 14 |
| 10 | Orbit determination for geostationary satellites with the combination of transfer ranging and pseudorange data显示文摘Geostationary satellites(GEOs) play a significant role in the regional satellite navigation system.Simulation experiments show that the clock corrections could be mitigated through a single strategy or double differencing strategies for a navigation constellation,but for the mode of individual GEO orbit determination,high precision orbit and clock correction could not be obtained in the orbit determination based on the pseudorange data.A new GEO combined precise orbit determination(POD) strategy is studied in this paper,which combines pseudorange data and C-band transfer ranging data.This strategy overcomes the deficiency of C-band transfer ranging caused by limited stations and tracking time available.With the combination of transfer ranging and pseudorange data,clock corrections between the GEO and the stations can be estimated simultaneously along with orbital parameters,maintaining self-consistency between the satellite ephemeris and clock correction parameters.The error covariance analysis is conducted to illuminate the contributions from the transfer ranging data and the psudoranging data.Using data collected for a Chinese GEO satellite with 3 C-band transfer ranging stations and 4 L-band pseudorange tracking stations,POD experiments indicate that a meter-level accuracy is achievable.The root-mean-square(RMS) of the post-fit C-band ranging data is about 0.203 m,and the RMS of the post-fit pseudorange is 0.408 m.Radial component errors of the POD experiments are independently evaluated with the satellite laser ranging(SLR) data from a station in Beijing,with the residual RMS of 0.076 m.The SLR evaluation also suggests that for 2-h orbital predication,the predicted radial error is about 0.404 m,and the clock correction error is about 1.38 ns.Even for the combination of one C-band transfer ranging station and 4 pseudorange stations,POD is able to achieve a reasonable accuracy with the radial error of 0.280 m and the 2-h predicted radial error of 0.888 m.Clock synchronization between the GEO and tracking stations is achieved with an estimated accuracy of about 1.55 ns,meeting the navigation service requirements. | GUO Rui1,2,3,4,HU XiaoGong2,4,LIU Li1,WU XiaoLi1,HUANG Yong2,4 & HE Feng1 1 Beijing Global Information Application and Development Center,Beijing 100094,China 2 Shanghai Astronomical Observatory,Chinese Academy of Sciences,Shanghai 200030,China 3 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 4 Space Navigation and Positioning Technology,Laboratory of Shanghai Municipal,Shanghai 200030,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，9： | 13 |
| 11 | An improvement on summer regional climate simulation over East China: Importance of data assimilation of soil moisture显示文摘The Newtonian relaxation is used to assimilate data from the Second Global Soil Wetness Project (GSWP2) into the initial field for soil moisture in a regional climate model (i.e., BCC_RegCM 1.0, hereinafter called RegCM). The results show that different nudging parameters can improve the simulation of the air temperature and the precipitation to some extent in summertime season over East China. When the nudging intensity is 0.5 and nudging duration is 5 days, the result is desirable. Introducing the data assimilation of soil moisture into RegCM, the amelioration is not only in the spatial distribution pattern but also in the magnitude of the temperature and the precipitation. More specifically, the assimilation experiments have corrected the systematical cold bias of the air temperature and the precipitation on the low side, which is much closer to the observation compared with the control experiment. On the whole, the assimilation experiments shed light on the fact that the simulated bias in the original RegCM may be affected by the description of soil moisture in the land surface process. Therefore, the effect of soil moisture in RegCM should be paid more attention in the future. | HU YaMin1,2,3, DING YiHui4 & LIAO Fei2 1 Institute of Tropical and Marine Meteorology, China Meteorological Administration, Guangzhou 510080, China 2 Guangdong Climate Center, Guangzhou 510080, China 3 Chinese Academy of Meteorological Sciences, Beijing 100081, China 4 National Climate Center, China Meteorological Administration, Beijing 100081, China | 2010 | Chinese Science Bulletin2010，55，9： | 13 |
| 12 | In situ experiments on width and evolution characteristics of excavation damaged zone in deeply buried tunnels显示文摘The seven long tunnels of Jinping II hydropower station are deeply buried.The width and evolution characteristics of excavation damaged zone(EDZ) are the key problem to the design of tunnels excavation and supports.In order to study this problem,several specific experimental tunnels with different overburden and geometric sizes were excavated at this site.Digital borehole camera,sliding micrometer,cross-hole acoustic wave equipment and acoustic emission apparatus were adopted.This paper introduced the comprehensive in situ experimental methods through pre-installed facilities and pre-drilled boreholes.Typical properties of the surrounding rock mass,including cracks,deformation,elastic wave and micro fractures,were measured during the whole process of the tunnel excavation.The width and characteristics of formation and evolution of tunnels EDZ were analyzed under different construction methods involving of TBM and drilling and blasting,the test tunnels were excavated by full-face or two benches.The relationships between EDZ and tunnel geometry sizes,overburden and excavation method were described as well.The results will not only contribute a great deal to the analysis of rock mass behavior in deeply buried rock mass,but also provide direct data for support design and rockburst prediction. | LI ShaoJun 1,FENG XiaTing 1,LI ZhanHai 3,CHEN BingRui 1,JIANG Quan 1,WU ShiYong 2,HU Bin 2 &XU JinSong 2 1 State Key Laboratory of Geomechanics and Geotechinical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences,Wuhan 430071,China 2 Ertan Hydropower Development Company,Ltd.,Chengdu 610051,China 3 School of Resources and Civil Engineering,Northeastern University,Shenyang 110004,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 13 |
| 13 | Dynamics analysis and experiment on the fishtailing type of valveless piezoelectric pump with rectangular vibrator显示文摘In recent years, the research and development of piezoelectric pumps have become an increasingly popular topic. Minimization, structure simplification and stronger output become the focus of piezoelectric pumps’ research due to its possible application in MEMS technology. The valveless fishtailing piezoelectric pump, neither a volumetric nor a rotating pump, was invented according to the bionics of fish swimming. With assumption that the head of the fish is fixed while its tail is swinging, fluid would flow toward the end of the tail, achieving the function of a valveless pump. This type of pumps creates a new branch for the piezoelectric pump research, which is proposed for the first time in this paper. The relationship between the flow rates and vibrating frequencies was derived from the interaction between the vibrator and fluid. Numerical simulations with FEM software were conducted to study the first and second vibration modes of the piezoelectric vibrator. The results showed that the maximum amplitude of the vibrator was 0.9 mm at the frequency of 76 Hz for the first vibration mode, while the maximum amplitude of the vibrator was 0.22 mm at the frequency of 781 Hz for the second vibration mode. Experiments were conducted with the Doppler laser vibration measurement system, and the results were compared to those of the FEM simulation. It was shown that in the first vibration mode the piezoelectric vibrator reached its maximum amplitude of about 0.9 mm at the driving frequency of 49 Hz, which gives the flow rate of 2.0 mL/min, in the second vibration mode, the maximum amplitude was about 0.25 mm at the frequency of 460 Hz with the flow rate being 6.4 mL/min. | HUANG Yi1, ZHANG JianHui1, HU XiaoQi1, XIA QiXiao2, HUANG WeiQing1 & ZHAO ChunSheng1 1 Department of Aerospace Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China 2 Department of Mechanical and Electrical Engineering, Beijing Union University, Beijing 100020, China | 2010 | Science China(Technological Sciences)2010，53，12： | 10 |
| 14 | Total control-based unified allocation model for allowable basin water withdrawal and sewage discharge显示文摘In this paper,a new model with a total amount control target of allowable water withdrawal based on initial water right is built for the implementation of initial water right allocation scheme as well as unified allocation for allowable water withdrawal and sewage discharge.The model couples the water allocation simulation model and the computational model of permissible pol-lution bearing capacity.In view of the model complexity,a new technology which synthesizes system simulation,iterative reservoir turns and intelligent computation is proposed to improve the operability of allocation scheme and computational efficiency.Taking the Beijiang River Basin in the Pearl River Basin as an example,the study explains the model establishment,solution and application,and draws an optimized operation graph of large-scale reservoirs.The study also obtains a long-term operation strategy of river basin water resources system,the allocation schemes of allowable water withdrawal and sewage discharge in a typical year and the flow hydrographs of trans-boundary sections.The validity of the model and the allocation rationality are analyzed as well. | HU SiYi1,2,WANG ZongZhi1,WANG YinTang1 & ZHANG LingLing3 1 State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering,Nanjing Hydraulic Research Institute,Nanjing 210029,China 2 Ministry of Water Resources,the People’s Republic of China,Beijing 100053,China 3 School of Public Administration,HoHai University,Nanjing 210098,China | 2010 | Science China(Technological Sciences)2010，53，5： | 10 |
| 15 | Identification of in vivo induced protein antigens of Salmonella enterica serovar Typhi during human infection显示文摘During infectious disease episodes, pathogens express distinct subsets of virulence factors which allow them to adapt to different environments. Hence, genes that are expressed or upregulated in vivo are implicated in pathogenesis. We used in vivo induced antigen technology (IVIAT) to identify antigens which are expressed during infection with Salmonella enterica serovar Typhi. We identified 7 in vivo induced (IVI) antigens, which included BcfD (a fimbrial structural subunit), GrxC (a glutaredoxin 3), SapB (an ABC-type transport system), T3663 (an ABC-type uncharacterized transport system), T3816 (a putative rhodanese-related sulfurtransferase), T1497 (a probable TonB-dependent receptor) and T3689 (unknown function). Of the 7 identified antigens, 5 antigens had no cross-immunoreactivity in adsorbed control sera from healthy subjects. These 5 included BcfD, GrxC, SapB, T3663 and T3689. Antigens identified in this study are potential targets for drug and vaccine development and may be utilized as diagnostic agents. | HU Yong1,2, CONG YanGuang1, LI Shu1, RAO XianCai1, WANG Gang3 & HU FuQuan1 1 Department of Microbiology, Third Military Medical University, Chongqing 400038, China 2 Department of Biotechnology, Chongqing University of Technology, Chongqing 400050, China 3 Department of Clinical Laboratory, The 3rd Hospital of People’s Liberation Army, Baoji 721004, China | 2009 | Science China(Life Sciences)2009，52，10： | 9 |
| 16 | Cloning of the non-structural gene 3 of hepatitis C virus and its inducible expression in cultured cells显示文摘METHODSThens3genewasobtainedfromplasmidpBns3bypolymerasechainreactionandinsertedintothecloningvectorpGEMT.Then,thens3wassubc... | ZHANG Shu Zhong 1, LIANG Jia Jing 1, QI Zhong Tian 2 and HU Yi Ping 1 | 1999 | World Journal of Gastroenterology1999，5，2： | 9 |
| 17 | Effects of sand burial on biomass, chlorophyll fluores-cence and extracellular polysaccharides of man-made cyanobacterial crusts under experimental conditions显示文摘Soil cyanobacterial crusts occur throughout the world, especially in the semiarid and arid regions. It always encounters sand burial, which is an important feature of mobile sand dunes. A greenhouse study was conducted to determine the effects of sand burial on biomass, chlorophyll fluorescence and extracellular polysaccharides of man-made cyanobacterial crusts in six periods of time (0, 5, 10, 15, 20 and 30 d after burying) and at five depths (0, 0.2, 0.5, 1 and 2cm). The results indicated that with the increase of the burial time and burial depth extracellular polysaccharides content and Fv/Fm decreased correspondingly and there were no significant differences between 20 and 30 burial days under dif-ferent burial depths. The degradation of chlorophyll a content appeared only at 20 and 30 burial days and there was also no significant difference between them under different burial depths. It was also observed a simultaneous decrease of the values of the Fv/Fm and the content of extracellular poly-saccharides happened in the crusted cyanobacterium Microcoleus vaginatus Gom. It may suggest that there exists a relationship between extracellular polysaccharides and recovery of the activity of pho-tosystem II (PS II) after rehydration. | WANG WeiBo1,2, YANG CuiYun1,2, TANG DongShan1,2, LI DunHai1, LIU YongDing1& HU ChunXiang1 1 State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100039, China | 2007 | Science China(Life Sciences)2007，50，4： | 9 |
| 18 | A semi-implicit semi-Lagrangian global nonhydrostatic model and the polar discretization scheme显示文摘The Global/Regional Assimilation and PrEdiction System(GRAPES) is a newly developed global non-hydrostatic numerical prediction model,which will become the next generation medium-range opera-tional model at China Meteorological Administration(CMA).The dynamic framework of GRAPES is featuring with fully compressible equations,nonhydrostatic or hydrostatic optionally,two-level time semi-Lagrangian and semi-implicit time integration,Charney-Phillips vertical staggering,and complex three-dimensional pre-conditioned Helmholtz solver,etc.Concerning the singularity of horizontal momentum equations at the poles,the polar discretization schemes are described,which include adoption of Arakawa C horizontal grid with ν at poles,incorporation of polar filtering to maintain the computational stability,the correction to Helmholtz equation near the poles,as well as the treatment of semi-Lagrangian interpolation to improve the departure point accuracy,etc.The balanced flow tests validate the rationality of the treatment of semi-Lagrangian departure point calculation and the polar discretization during long time integration.Held and Suarez tests show that the conservation proper-ties of GRAPES model are quite good. | YANG XueSheng1,CHEN JiaBin2,HU JiangLin1,CHEN DeHui1,SHEN XueShun1,ZHANG HongLiang1 1 State Key Laboratory of Severe Weather,Chinese Academy of Meteorological Sciences,Beijing 100081,China 2 State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics,Institute of Atmospheric Physics,Beijing 100029,China | 2007 | Science China Earth Sciences2007，50，12： | 9 |
| 19 | Expression of liver cancer associated gene HCCA3显示文摘AIM: To study and clone a novel liver cancer reisted gene,and to explore the molecular basis of liver cancer genesis.METHODS: Using mRNA differential display polymerasechain reaction (DDPCR), we investigated the difference of mRNA in human hepatocellular carcinoma (HCC) and paired surrounding liver tissues, and got a gene probe. By screening a human placenta cDNA library and genomic homologous extend, we obtained a full-length cDNA named HCCA3. We analyzed the expression of this novel gene in 42pairs of HCC and the surrounding liver tissues, and distribution in human normal tissues by means of Northern blot assay.RESULTS: A full-length cDNA of liver cancer associated gene HCCA3 has been submitted to the GeneBank nucleotide sequence databases ( Accession No. AF276707 ). The positive expression rate of this gene was 78.6% (33/42) in HCC tissues, and the clinical pathological data showed that the HCCA3 was closely associated with the invasion of tumor capsule ( P = 0.023) and adjacant small metastasis satellite nodules lesions ( P= 0.041). The HCCA3 was widely distributed in the human normal tissues, which was intensively expressed in lungs, brain and colon tissues,while lowly expressed in the liver tissues.CONCLUSION: A novel full-length cDNA was cloned and differentiated, which was highly expressed in liver cancer tissues. The high expression was closely related to the tumor invasiveness and metastasis, that may be the late heredited change in HCC genesis. | Zheng-Xu Wang~1 Gui-Fang Hu~1 Hong-Yang Wang~2 Meng-Chao Wu~2 1 Department of General Surgery,Chinese PEA General Hospital of Lanzhou Military Command,Lanzhou 730050,Gansu Province,China2 Eastern Hepatobilliary Surgical Hospital,Second Military Medical University,Shanghai 200438,China | 2001 | World Journal of Gastroenterology2001，7，6： | 9 |
| 20 | Natural gas geochemistry and its origins in Kuqa depression显示文摘According to gas compositional and carbon isotopic measurement of 114 gas samples from the Kuqa depression,accumulation of the natural gases in the depression is dominated by hydrocarbon gases, with high gas dryness(C1/C1-4)at the middle and northern parts of the depression and low one towards east and west sides and southern part.The carbon isotopes of methane and its homologues are relatively enriched in 13 C,and the distributive range ofδ13C 1 ,δ13C 2 andδ13C 3 is-32‰―-36‰,-22‰―-24‰and-20‰―-22‰,respectively.In general,the carbon isotopes of gaseous alkanes become less negative with the increase of carbon numbers.Theδ13C CO2 value is less than-10‰in the Kuqa depression,indicating its organogenic origin.The distributive range of 3 He/ 4 He ratio is within n×10-8 and a decrease in 3 He/ 4 He ratio from north to south in the depression is observed.Based on the geochemical parameters of natural gas above,natural gas in the Kuqa depression is of characteristics of coal-type gas origin.The possible reasons for the partial reversal of stable carbon isotopes of gaseous alkanes involve the mixing of gases from one common source rock with different thermal maturity or from two separated source rock intervals of similar kerogen type,multistages accumulation of natural gas under high-temperature and over-pressure conditions,and sufficiency and diffusion of natural gas. | LIU QuanYou 1 ,QIN ShengFei 1 ,LI Jian 2 ,LIU WenHui 3 ,ZHANG DianWei 3 ,ZHOU QingHua 1 &HU AnPing 1 1 Research Institute of Petroleum Exploration and Development,PetroChina,Beijing 100083,China 2 Langfang Branch of Research Institute of Petroleum Exploration and Development,PetroChina,Langfang 065007,China 3 Exploration and Production Research Institute,SINOPEC,Beijing 100083,China | 2008 | Science China Earth Sciences2008，51，S1： | 9 |
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