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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hbouxucv5oco06uux.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 4 | Valuing Foreign Cur- rency Options with a Mean-Reverting Process : A Study of Hong Kong Dollar 显示文摘 | Hui C H Lo C F Yeung V | 2008 | International Journal of Finance & Econom- ics2008，13，1： | 1 |
| 5 | A framework for a logistics E-commerce community network:The Hong Kong air cargo industry显示文摘 | Leung L C Cheung W Hui Y V | 2000 | IEEE Transactions on SMC2000，30，4： | 1 |
| 6 | CD8( + ) T-cell re- sponses to adeno-associated virus eapsid in humans显示文摘 | Mingozzi F Maus M V Hui D J | 2007 | Nat Med2007，13，4： | 1 |
| 7 | Microbial and biochemical spoilage of foods: an overview显示文摘 | JOS H J HUIS I V | 1996 | International Journal of Food Microbiology1996，33，2： | 1 |
| 8 | A double-blind, crossover assessment of the sedative and analgesic effects of in- tranasal dexmedetomidine显示文摘 | YUEN V M IRWIN M G HUI T W | 2007 | Anesthesia and Analgesia2007，105，2： | 1 |
| 9 | A parameter optimization method for the radial basis function type models显示文摘 | PENG Hui Ozaki T Haggan-Ozaki V | 2003 | IEEE Transactions on Neural Networks2003，14，2： | 1 |
| 10 | An empirical assessment and ap- plication of SERVQUAL in a Mainland Chinese department store显示文摘 | ZHAO X D BAI C H HUI Y V | 2002 | Total Quality Management2002，13，2： | 1 |
| 11 | Kappa- Hefutoxinl, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function: Importance of the functional diad in potassium channel selectivity显示文摘 | SRINIVASAN K N SIVARAJA V HUYS I | 2002 | J Biol Chem2002，277，30： | 1 |
| 12 | Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma显示文摘 | Chan H L Hui A Y Wong M L Tse A M Hung L C Wong V W | 2004 | Gut2004，53，： | 1 |
| 13 | An analysis of spatial forest structure using neighborhood-based variables 显示文摘 | AGUIRRE O HUI G Y GADOW K V | 2003 | Forest Ecology and Management2003，183，： | 1 |
| 14 | Airfreight forwarder shipment planning: A mixed 0-1 model and managerial issues in the integration and consolidation of shipments 显示文摘 | Wong W H Leung L C Hui Y V | 2009 | European Journal of Operational Researeh2009，193，： | 1 |
| 15 | (x)2 optimal semistable control for linear dynamical systems:An LMI approach显示文摘 | HADDAD W M HUI Q CHELLABOINA V | | 0，，： | 1 |
| 16 | Das Winkelmass-Theoretische Uberlegungen zum optimalen Standardwinkel 显示文摘 | Hui G Y Gadow K V | 2002 | Allgemeine Forst- Und Jagdzei- tung2002，173，： | 1 |
| 17 | A 0-1 LP Model for the integration and consolidation of air cargo Shipments显示文摘 | Leung L C Hui Y V Wang Y | 2009 | Operation Research2009，57，2： | 1 |
| 18 | An analysis of spatial forest structure using neighborhood-based variables 显示文摘 | Aguirre O Hui G Y Gadow K V | 2003 | For Ecol Manage2003，183，： | 1 |
| 19 | Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis:in vivo显示文摘 | Williams JM Plaza V Hui F | 1997 | Osteoarthritis Cartilage1997，5，4： | 1 |
| 20 | Das Winkelmass-Theoretische uberlegungen zum optimalen Standardwinkel 显示文摘 | Hui G Y Gadow K V | 2002 | Allg Forst-u J-Ztg2002，173，： | 1 |
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