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| 1 | Dry matter intake and nutrient digestibility in Muzaffarari lambs fed diet with varing concentrate roughage rations显示文摘 | Hyder M D | | 0，，： | 1 |
| 2 | Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures显示文摘 | Petroff O A Hyder F Rothman D L | 2001 | Neurology2001，56，6： | 1 |
| 3 | Seedling morphology and seedling failures with blue grama显示文摘 | Hyder D N Everson A C Bement R E | 1971 | Journal of Range Management1971，24，： | 1 |
| 4 | Neurophysiology of Functional imaging显示文摘 | van Eijsden P Hyder F Rothman D L | 2009 | Neuro Image2009，45，4： | 1 |
| 5 | In vivo NMR studies of the neurotransmitter flux and neuroenergetics -im- plications for brain function显示文摘 | ROTHMAN D L BEHAR K L HYDER F | 2003 | Annu Rev Physiol2003，65，： | 1 |
| 6 | Cadmium exposure and liver disease among US adults显示文摘 | Hyder O Chung M Cosgrove D | 2013 | J Gastrointest Surg2013，17，7： | 1 |
| 7 | Treated Kaolin Combines Effective Pitch Control with Handling Ease显示文摘 | Carter A R D Hyder J | 1993 | Pulp & Paper1993，67，11： | 1 |
| 8 | Dy-namic fMRI and EEG recordings during spike-wave seizuresand generalized tonic-clonic seizures in wag/Rij rats显示文摘 | NERSESYAN H HYDER F ROTHMAN D L | 2004 | JCereb Blood Flow Metab2004，24，6： | 1 |
| 9 | Hydro- gels:assembly of viral hydrogels for three-dimensional conducting nanocomposites ( Adv Mater 30/2014 ) 显示文摘 | CHEN P Y HYDER M rq MACKANIC D | 2014 | Advanced Materials2014，26，30： | 1 |
| 10 | Slug tests in par- tially penetrating wells显示文摘 | Hyder Z Butler JR JJ Mcelwee C D | 1994 | Water Resources Research1994，30，11： | 1 |
| 11 | A brief primer on Good Samaritan law for health care professionals显示文摘 | Hyder G John D | 2007 | Australian Health Review2007，31，3： | 1 |
| 12 | Influence of soil geochemical and physical properties on the sorption and bioaccessibility of chromium (III)显示文摘 | STEWART M A JARDINE P M BARNETT M O MEHLHOM T L HYDER L K MCKAY L D | 2003 | Journal of Environmental Quality2003，32，1： | 1 |
| 13 | Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States显示文摘BACKGROUND Helicobacter pylori(H.pylori),a bacterium that infects approximately half of the world’s population,is associated with various gastrointestinal diseases,including peptic ulcers,non-ulcer dyspepsia,gastric adenocarcinoma,and gastric lymphoma.As the burden of antibiotic resistance increases,the need for new adjunct therapies designed to facilitate H.pylori eradication and reduce negative distal outcomes associated with infection has become more pressing.Characterization of the interactions between H.pylori,the fecal microbiome,and fecal fatty acid metabolism,as well as the mechanisms underlying these interactions,may offer new therapeutic approaches.AIM To characterize the gut microbiome and metabolome in H.pylori patients in a socioeconomically challenged and underprivileged inner-city community.METHODS Stool samples from 19 H.pylori patients and 16 control subjects were analyzed.16S rRNA gene sequencing was performed on normalized pooled amplicons using the Illumina MiSeq System using a MiSeq reagent kit v2.Alpha and beta diversity analyses were performed in QIIME 2.Non-targeted fatty acid analysis of the samples was carried out using gas chromatography-mass spectrometry,which measures the total content of 30 fatty acids in stool after conversion into their corresponding fatty acid methyl esters.Multi-dimensional scaling(MDS)was performed on Bray-Curtis distance matrices created from both the metabolomics and microbiome datasets and a Procrustes test was performed on the metabolomics and microbiome MDS coordinates.RESULTS Fecal microbiome analysis showed that alpha diversity was lowest in H.pylori patients over 40 years of age compared to control subjects of similar age group.Beta diversity analysis of the samples revealed significant differences in microbial community structure between H.pylori patients and control subjects across all ages.Thirty-eight and six taxa had lower and higher relative abundance in H.pylori patients,respectively.Taxa that were enriched in H.pylori patients included Atopobium,Gemellaceae,Micrococcaceae,Gemellales and Rothia(R.mucilaginosa).Notably,relative abundance of the phylum Verrucomicrobia was decreased in H.pylori patients compared to control subjects.Procrustes analysis showed a significant relationship between the microbiome and metabolome datasets.Stool samples from H.pylori patients showed increases in several fatty acids including the polyunsaturated fatty acids(PUFAs)22:4n6,22:5n3,20:3n6 and 22:2n6,while decreases were noted in other fatty acids including the PUFA 18:3n6.The pattern of changes in fatty acid concentration correlated to the Bacteroidetes:Firmicutes ratio determined by 16S rRNA gene analysis.CONCLUSION This exploratory study demonstrates H.pylori-associated changes to the fecal microbiome and fecal fatty acid metabolism.Such changes may have implications for improving eradication rates and minimizing associated negative distal outcomes. | Brian White John D Sterrett Zoya Grigoryan Lauren Lally Jared D Heinze Hyder Alikhan Christopher A Lowry Lark J Perez Joshua DeSipio Sangita Phadtare | 2021 | World Journal of Gastroenterology2021，27，33： | 1 |
| 14 | 查看详情显示文摘 | Hyder M N Lee S W Cebeci F C Schmidt D J Yang S H Hammond P T | | 0，，11： | 1 |
| 15 | Emergency medical system in low and middle-income countries:recommendations for action显示文摘 | Kobusingye O Hyder A Bishai D | 2005 | Bulletin of WHO2005，，83： | 1 |
| 16 | Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partialseizures显示文摘 | Petroff O A Hyder F Rothman D L | 2001 | Neurology2001，56，6： | 1 |
| 17 | Dry matter intake and nutrient digestibility in Muzaffarari lambs fed diet with raring concentrate roughage rations显示文摘 | Hyder M D | 1979 | Anim Sci1979，49，： | 1 |
| 18 | Newspaper reports as a sourcefor injury data in developing countries显示文摘 | GHAFFAR A HYDER AA BISHAI D | 2001 | Health Policy Plan2001，16，3： | 1 |
| 19 | Neurophysiology of functional imaging 显示文摘 | EIJSDEN P van HYDER F ROTHMAN D L | 2009 | Neuroimage2009，45，4： | 1 |
| 20 | Investigations ofelectrospray sample deposition for polymer MALDI mass spectrometry显示文摘 | Hanton S D Hyder l Z Stets J R | 2004 | J Am Soc Mass Spectrom2004，15，： | 1 |
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