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| 1 | Release of interleukin-10 and neurotrophic factors in the choroid plexus:possible inductors of neurogenesis following copolymer-1 immunization after cerebral ischemia显示文摘Copolymer-1(Cop-1) is a peptide with immunomodulatory properties, approved by the Food and Drug Administration of United States in the treatment of multiple sclerosis. Cop-1 has been shown to exert neuroprotective effects and induce neurogenesis in cerebral ischemia models. Nevertheless, the mechanism involved in the neurogenic action of this compound remains unknown. The choroid plexus(CP) is a network of cells that constitute the interphase between the immune and central nervous systems, with the ability to mediate neurogenesis through the release of cytokines and growth factors. Therefore, the CP could play a role in Cop-1-induced neurogenesis. In order to determine the participation of the CP in the induction of neurogenesis after Cop-1 immunization, we evaluated the gene expression of various growth factors(brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3) and cytokines(tumor necrosis factor alpha, interferon-gamma, interleukin-4(IL-4), IL-10 and IL-17), in the CP at 14 days after ischemia. Furthermore, we analyzed the correlation between the expression of these genes and neurogenesis. Our results showed that Cop-1 was capable of stimulating an upregulation in the expression of the genes encoding for brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3 and IL-10 in the CP, which correlated with an increase in neurogenesis in the subventricular and subgranular zone. As well, we observed a downregulation of IL-17 gene expression. This study demonstrates the effect of Cop-1 on the expression of growth factors and IL-10 in the CP, in the same way, presents a possible mechanism involved in the neurogenic effect of Cop-1. | Yolanda Cruz Edna E.García Jessica V.Gálvez Stella V.Arias-Santiago Horacio G.Carvajal Raúl Silva-García Herlinda Bonilla-Jaime Julio Rojas-Castaneda Antonio Ibarra | 2018 | Neural Regeneration Research2018，13，10： | 7 |
| 2 | Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury显示文摘Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides(INDP), inhibition of glial scar formation(dipyridyl: DPY), as well as the use of biocompatible matrix(fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells(MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI. Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups: 1) phosphate buffered saline; 2) DPY; 3) INDP + DPY; 4) DPY+ FG; 5) INDP + DPY + FG + MSCs. In all rats, intervention was performed 72 hours after spinal cord injury. Locomotor and sensibility recovery was assessed in all rats. At 60 days after treatment, histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining) were performed. Our results showed that the combination therapy(DPY+ INDP + FG+ MSCs) was the best strategy to promote motor and sensibility recovery. In addition, significant increases in tissue preservation and axonal density were observed in the combination therapy group. Findings from this study suggest that the combination theapy(DPY+ INDP + FG + MSCs) exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury. All procedures were approved by the Animal Bioethics and Welfare Committee(approval No. 178544; CSNBTBIBAJ 090812960)on August 15, 2016. | Elisa García Roxana Rodríguez-Barrera Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla Marco Guerrero-Godinez Estefanía De la Cruz-Castillo Laura Castillo-Carvajal Monserrat Rivas-Gonzalez Paola Santiago-Tovar Ivis Morales Cesar Borlongan Antonio Ibarra | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 3 | Larval growth and survival of two catarina scallop ( Argopecten circularis , Sowerby, 1835 )populations and their reciprocal crosses 显示文摘 | Cruz P Ibarra A M | 1997 | Journal of Experimental Marine Biology and Ecology1997，212，： | 1 |
| 4 | Pheochromocytoma of the urinary bladder 显示文摘 | Albores-Saavedra J Maldonado M E Ibarra J Rodriguez H A | 1969 | Cancer1969，23，5： | 1 |
| 5 | Effects of in- breeding on growth and survival of self-fertilized catarina scallop larvae, Argopecten circularis 显示文摘 | Ana M Ibarra Pedro Cruz Blanca A | 1995 | Aquaculture1995，134，： | 1 |
| 6 | Larval growth and survival of two catarina scallop (Argopecten circularis, Sowerby, 1835 )populations and their reciprocal crosses显示文摘 | CRUZ P IBARRA A M | 1997 | Journal of Experimental Marine Biologl and Ecology1997，212，： | 1 |
| 7 | Use of cholinesterase activity in monitoring organophosphate pesticide exposure of cattle produced in tropical areas显示文摘 | PARDIO V T IBARRA N RODRIGUEZ M A | 2001 | J Agric Food Chem2001，49，12： | 1 |
| 8 | How far do shocks move across borders? Examining volatility transmission in major agricultural futures markets显示文摘 | Hernandez M A Ibarra R Trupkin D R | 2011 | European Review of Agricultural Economics2011，41，2： | 1 |
| 9 | FT-IR investigation on char formation during the early stages of coal pyrolysis显示文摘 | IBARRA J V MILINER R BONET A J | 1994 | Fuel1994，73，6： | 1 |
| 10 | Hexabromo- cyclododecanes in indoor dust from Canada, the United Kingdom, and the United States 显示文摘 | Abdallah M A E Harrad S Ibarra C | 2008 | Environ Sci Technol2008，42，2： | 1 |
| 11 | Cdc45-MCM-GINS,a new power player for DNA replication显示文摘 | Aparicio T Ibarra A Mendez J | 2006 | Cell Div2006，1，： | 1 |
| 12 | FIR investigation on char formation during the early stages of coal pyrolysis 显示文摘 | Ibarra J V Moliner R Bonet A | 1994 | Fuel1994，73，6： | 1 |
| 13 | Detection of new cry genes of Bacillus thuringiensis by use of a novel PCR primer system显示文摘 | Noguera P A Ibarra J E | | 0，，18： | 1 |
| 14 | Feasible predictive criteria for reproductive performance of white shrimp Litopenaeus vannamei : egg quality and female physiological condition显示文摘 | Arcos F G Ibarra A M Palacios E | 2003 | Aquaculture2003，228，14： | 1 |
| 15 | Physical Review B 显示文摘 | Morellon L Algarabel P A Ibarra M R | 1998 | 58(22): R147211998，58，14： | 1 |
| 16 | Photosynthesis, soil temperature and yield of cucumber as affected by colored plastic mulch显示文摘 | IBARRA J L ZERMENO G A MUNGUIA L J | 2008 | Acta Agriculturae Scandinavica (Section B) -Soil and Plant Science2008，58，4： | 1 |
| 17 | Larval growth and survival of two catarinascallop(Argopecten cirularis,Sowerby,1835)population and theirreciprocal crosses显示文摘 | Pedro C Ibarra A M | 1997 | Journal of Experimental Marine Biology andEcology1997，212，1： | 1 |
| 18 | Vaccination with a Nogo-A-derived peptide after incomplete spinal-cord injury promotes recovery via a T-cell-mediated neuroprotective response: comparison with other myelin antigens显示文摘 | Hauben E Ibarra A Mizrahi T | 2001 | Proc Natl Acad Sci USA2001，98，15： | 1 |
| 19 | Effects of cyclosporin-A on immune response,tissue protection and motor function of rats subjected to spinal cord injury显示文摘 | Ibarra A Correa D Willms K | 2003 | Brain Res2003，979，12： | 1 |
| 20 | Comparing cell viability and ethanol fermentation of the thermotolerant yeast Kluyvero- myces marxianus and Saccharomyces cerevisiae on steam-exploded biomass treated with laccase显示文摘 | MORENO A D IBARRA D BALLESTEROS I | 2013 | Bioresource Technol2013，135，： | 1 |
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