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| 1 | Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization显示文摘AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were used.Corneal NV was induced by NaOH in the left eyes of each rat.Following the establishment of alkali burn,the animals were randomized into five groups according to topical treatment.Group 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone phosphate.On the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer-imaging analysis.The corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by immunostaining.RESULTS:A statistically significant difference in the percent area of corneal NV was found among the groups(P<0.001).Although the Group 5 had the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and 2.CONCLUSION:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats. | Halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Effect of dietary protein level and strain on growth performance of heat stressed broiler chicks显示文摘 | Rashid H O S Huwaida E E M Ibrahim Y A | 2012 | International Journal of Poultry Science2012，11，10： | 1 |
| 3 | Improvement of functional properties of egg white protein through phosphorylation by dryheating in the presence of pyrophosphate显示文摘 | LI C P IBRAHIM H R SUGIMOTO Y | 2004 | J Agric Food Chem2004，52，： | 1 |
| 4 | Study of gastro-intestinal helminths of scavenging chickens in four rural districts of Amhara region, Ethiopia 显示文摘 | Eshetu Y Mulualem E Ibrahim H | 2001 | Revue seientifique et technique (International Office of Epizootics)2001，20，： | 1 |
| 5 | The theoretical and experimental investigation of blank holder forces plate effect in deep drawing process of AL 1050 material 显示文摘 | H Ibrahim Demirci Mustafa Y Kemal Demiray b | 2008 | Materials and Design2008，29，： | 1 |
| 6 | Optimization of medium for the production of β-cyclodextrin glucanotransferase using central composite design (CCD)显示文摘 | IBRAHIM H M WAN M Y HAMID A A | 2005 | Process Biochemistry2005，，40： | 1 |
| 7 | Recent advances in flat plate photovoltaic/thermal (PV II) solar collectors显示文摘 | Ibrahim A Othman M Y Ruslan M H | 2011 | Renewable and Sustainable Energy Reviews2011，15，1： | 1 |
| 8 | Temperature-dependent evolution of the electronic and local atomic structure in the cubic colossal magnetoreslstlve mangamte Rev B,2008,77 125134 (1 Lal-x Srx Mn03 显示文摘 | Mannella N Booth C H Rosenhahn A Sell B C Nam-bu A Marchesini S Mun B S Yang S H Watanabe M Ibrahim K Arenholz E Young A Guo J Tomioka Y Fadley C S | 2008 | Phys2008，19，： | 1 |
| 9 | Magnetic sol- id-phase extraction based on modified ferum oxides for enrichment, preconcentration, and isolation of pesticides and selected pollutants显示文摘 | Wa Wan Ibrahim Nodeh H R Ahoul-Enein H Y | 2015 | Critical Reviews in Analytical Chemistry2015，45，3： | 1 |
| 10 | Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice显示文摘 | Yang H Y Liu S L Ibrahim S A | 2009 | Nutrition Research2009，29，4： | 1 |
| 11 | Identification of a distinct antibacterial domain within the N-lobe of ovotransferrin显示文摘 | Ibrahim H R E Iwamori Y Sugimoto | 1998 | Biochim Biophys Acta1998，1401，3： | 1 |
| 12 | Ovotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism显示文摘 | Ibrahim H R Y Sugimoto T Aoki | 2000 | Biochim Biophys Acta2000，1523，23： | 1 |
| 13 | Printing cotton fabrics with reactive dyes of high reactivity from an acidic print- ing paste显示文摘 | EI-Hamaky Y H Tawfeek S Ibrahim D F | 2007 | Coloration Technology2007，123，6： | 1 |
| 14 | Ovotranaferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism显示文摘 | Ibrahim H R Sugimoto Y Aoki T | 2000 | Biochim Biophys Acta2000，1523，23： | 1 |
| 15 | AtomicEmission Spectrometric Determination of Antazoline,Hydralazine and Amiloride Hydrochlorides 5 and QuinineSulfate Based on Formation of Ion Associates withManganese Thiocyanate显示文摘 | Shoukry A F Issa Y M Ibrahim H | 1995 | Analyst1995，120，4： | 1 |
| 16 | The rise of 'big data' on cloud computing: Review and open research issues显示文摘 | Ibrahim A T H Ibrar Y Anuar N B | 2015 | Information Systems2015，47，： | 1 |
| 17 | Ovotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism显示文摘 | Ibrahim H R Sugimoto Y Aoki T | 2000 | Biochim Biophys Acta2000，1523，23： | 1 |
| 18 | Intrinsic regression models for positivedefinite matrices with applications to diffusion tensor 显示文摘 | Zhu H T Chen Y Ibrahim J G Li Y Hall C and Lin W | 2009 | Journal of the American Statistical Association2009，104，： | 1 |
| 19 | Improvement of functional properties of egg white protein through phosphorylation by dry-heating in the presence of pyrophosphate显示文摘 | LI C P IBRAHIM H R SUGIMOTO Y | 2004 | J Agile Food Chem2004，52，18： | 1 |
| 20 | Postoperative pain in multiple-visit and single-visit root canal treatment显示文摘 | El Mubarak A H Abu-bakr N H Ibrahim Y E | 2010 | J Endod2010，36，1： | 1 |
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