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1经导管动脉栓塞术治疗肝癌:最新临床证据显示文摘对不能接受根治性治疗如肝移植、肿瘤切除术或经皮射频消融术(radiofrequency ablation,RFA)的肝细胞肝癌(hepatocellular carcinoma,HCC)患者,经导管动脉化疗栓塞术(transarterial chemoembolization,TACE)或放疗栓塞术(transarterial radioembolization,TARE)是治疗的核心手段。近期研究证据显示:对于无血管侵犯、3 cm及以下单结节型HCC患者,TACE与肿瘤切除术及RFA后的5年总生存率相似。尽管已应用数十年,碘油(超液化碘油®,Lipiodol®Ultra Fluid,Guerbet,France)作为一种亲肿瘤性且不透射线的药物运输载体在肿瘤介入治疗中的地位依然重要。药物缓释微球(drug-eluting bead,DEB)是栓塞术中一种较新型的药物输送方式,既可维持药物浓度,也可持续释放抗癌药。现有三种DEB可供临床选择使用,即Tandem®(Celo Nova Biosciences Inc.),DC-Beads®(BTG,UK)和Hepa Sphere®(Bio Sphere Medical,Inc.,USA)。经动脉TARE已被证实可安全有效地运用于晚期肝癌及有肝血管侵犯的患者。两种放射性栓塞微粒可供临床选择使用,即SIR-Spheres®(Sirtex Medical Limited,Australia)和Thera Sphere®(BTG,UK)。本文总结肝癌经导管动脉治疗的关键临床试验。Yì-Xiáng J.Wáng Thierry De Baere Jean-Marc Idée Sébastien Ballet 邓敏 王毅翔 2015临床与病理杂志2015,35,7:2
2An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse显示文摘Gavaghan CL Holmes E Lenz E Wilson ID Nicholson JK 2000FEBS Lett2000,484,3:2
3Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer显示文摘Kapiteijn E Marijnen CA Nagtegaal ID 2001N Engl J Med2001,345,9:1
4Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer显示文摘Kapiteijn E Marijnen CA Nagtegaal ID 2001N Engl J Med2001,345,:1
5Preoperative radiotherapy combined with total mesorectal excision for respectable rectal cancer显示文摘Kapteijn E Marijnen CA Nagtegaal ID 2001N Engl J Med2001,345,9:1
6Preopera- tive radiotherapy combined with total mesoreetal excision for resectable reetal caneer显示文摘Kapiteijn E Marijnen CA Nagtegaal ID et ai 2001N Engl J Med2001,345,9:1
7Shewanella secretes flavins that mediate extracellular electron transfer显示文摘Marsili E Baron DB Shikhare ID 2008Proceedings of the National Academy of Sciences of the United States of Ameria2008,105,10:1
8Comparison of complications of total thyroidectomy in malignant vs benign thyroid tumors 显示文摘Iddings D Saha S Walsh E 2008ASCO Meeting Abstracts2008,26,17:1
9Immunopathological examination of e- sophagus as a useful criterion of cure in pemphi- gus vulgaris显示文摘Torzecka ID Sysa-Jedrzejowska A Waszezykows- ka E 1999JEADV1999,12,2:1
10Preoperative ra- diotherapy combined with total mesorectal excision for reseetable rectal cancer显示文摘Kapiteijn E Marijnen CA Nagtegaal ID 2001N Engl J Med2001,345,9:1
11Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer 显示文摘Kapiteijn E Marijnen CA Nagtegaal ID 2001N Engl J Med2001,345,9:1
12Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells显示文摘Lliev ID Spadoni I Mileli E 2009Gut2009,58,:1
13Vesicoureteral reflux in a nonfunctioning kidney detected by 99m Tc-DTPA study显示文摘ORSAL E SEVEN B SUBASI ID 2013Jpn J Radiol2013,31,12:1
14Disposition of propofol administered as constant rate intravenous infusions in humans显示文摘Gepts E Camu F Cockshott ID 1987Anesth Analg1987,66,:1
15No downstaging after short-term preoperative radiotherapy in rectal cancer patients显示文摘Marijnen CA Nagtegaal ID Klein Kranenbarg E 2001J Clin Oncol2001,19,7:1
16Metabolic phenotyping in health and disease显示文摘Holmes E Wilson ID Nicholson JK 2008Cell2008,134,:1
17Supercfitical fluid extraction and Fraetionation of natural matter 显示文摘Reverchon E Marco ID 2006The Journal of Supercriti- ''al Fluids2006,38,2:1
18The use of induced sputum to investigate airway inflammation 显示文摘Pavord ID Pizzichini MM Pizzichini E 1997Thorax1997,52,:1
19Evaluation of CD4+CD161+CD196+ and CD4+IL-17+Th17 cells in the peripheral blood of young patients with Hashimoto's thyroiditis and Grave' disease显示文摘Bossowski A Moniuszko M Id(z)kowska E 0,,03:1
20Gut microorganisms, mammalian metabolism and personalized health care显示文摘Nicholson JK Holmes E Wilson ID 2005Nature Rev Mierobiol2005,3,5:1
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