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| 1 | Endoscopic papillary large balloon dilation for removal of bile duct stones显示文摘AIM:To investigate the efficacy and outcomes of endoscopic papillary large balloon dilation(EPLBD)for bile duct stones in a multicenter prospective study.METHODS:Lithotomy by EPLBD was conducted in 124patients with bile duct stones≥13 mm in size or with three or more bile duct stones≥10 mm.After endoscopic sphincterotomy,the papilla was dilated using balloons 12-20 mm in diameter fitting the bile duct diameter.RESULTS:The success rate of first-time lithotomy was 86.3%(107/124)and the final lithotomy success rate was 100%(124/124).Lithotripsy was needed in10 of the 124(13.6%)patients.Adverse events due to the treatment procedure occurred in 6(4.8%)patients,all of which were mild.Performing large balloon dilation after endoscopic sphincterotomy in patients with large stones or multiple stones in the bile duct is considered to ensure the safety of treatment and to reduce the need for lithotripsy.CONCLUSION:It is suggested that treatment by EPLBD for large bile duct stones may be safe and useful. | Yuji Sakai Toshio Tsuyuguchi Yoshiaki Kawaguchi Nobuto Hirata So Nakaji Katsuya Kitamura Shigeru Mikami Tatsuya Fujimoto Masashi Ijima Eishin Kurihara Shuhei Oana Takayoshi Nishino Ryo Tamura Dai Sakamoto Masato Nakamura Takao Nishikawa Harutoshi Sugiyama Hitoshi Yoshida Tetsuya Mine Osamu Yokosuka | 2014 | World Journal of Gastroenterology2014，20，45： | 6 |
| 2 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 3 | Safety and efficacy of metallic stent for unresectable distal malignant biliary obstruction in elderly patients显示文摘AIM To study the safety of insertion of metallic stents in elderly patients with unresectable distal malignant biliary obstruction.METHODS Of 272 patients with unresectable distal malignant biliary obstruction, 184 patients under the age of 80 were classified into Group A, and 88 subjects aged 80 years or more were classified into Group B. The safety of metallic stent insertion, metal stent patency period, and the obstruction rate were examined in each group.RESULTS In Group B, patients had a significantly worse per-formance status, high blood pressure, heart disease, cerebrovascular disease, and dementia; besides the rate of patients orally administered antiplatelet drugs or anticoagulants tended to be higher(P < 0.05). Metallic stents were successfully inserted in all patients. The median patency period was 265.000 ± 26.779(1-965) d; 252.000 ± 35.998(1-618) d in Group A and 269.000 ± 47.885(1-965) d in Group B, with no significant difference between the two groups. Metallic stent obstruction occurred in 82 of the 272(30.15%) patients; in 53/184(28.80%) patients in Group A and in 29/88(32.95%) of those in Group B, showing no significant difference between the two groups. Procedural accidents due to metal stent insertion occurred in 24/272(8.8%) patients; in 17/184(9.2%) of patients in Group A and in 7/88(8.0%) of those in Group B, with no significant difference between the two groups, either.CONCLUSION These results suggested that metallic stents can be safely inserted to treat unresectable distal malignant biliary obstruction even in elderly patients aged 80 years or more. | Yuji Sakai Tomohisa Iwai Kenji Shimura Katsushige Gon Kazuya Koizumi Masashi Ijima Kazuro Chiba Seigo Nakatani Harutoshi Sugiyama Toshio Tsuyuguchi Terumi Kamisawa Iruu Maetani Mitsuhiro Kida | 2018 | World Journal of Gastroenterology2018，24，1： | 4 |
| 4 | Pupillography of relative afferent pupillary defect contralateral to monocular mature cataract显示文摘 | Miki A Ijima A Usui T | 2006 | Can J Ophthalmol2006，41，4： | 1 |
| 5 | Expression of a liver spe- cific function by a hepatoblastoma cell line coculture with three dimensional endothelialized tubes in collagen geli 显示文摘 | Takei T Sakai S Ijima H | 2007 | J Biosci Bioeng2007，103，2： | 1 |
| 6 | Helical micrombules of graphitic carbon显示文摘 | Ijima S | 1991 | Nature Sci1991，354，6348： | 1 |
| 7 | In situ gellable oxidized cit- rus pectin for localized delivery of anticancer drugs and preven- tion of homotypie cancer cell aggregation 显示文摘 | Takei T Sato M Ijima H | 2010 | Biomacrumole- cules2010，11，12： | 1 |
| 8 | The response of the phosphate uptake system and the organic acid exudation system to phosphate starvation in Sesbania rostrata 显示文摘 | Aono T Kanada N Ijima A | 2001 | Plant Cell Physiol2001，42，： | 1 |
| 9 | Helical microtubules of graphitic carbon 显示文摘 | Ijima S | 1991 | Nature1991，354，： | 1 |
| 10 | Detection and sequencing of ro tavirusV P7 gene from human mateirals ( stoo ls, sera , cerebrospinal fluids, and thorat sawbs) by reverse transcription and PCR显示文摘 | Ush ijima H Xin KE N ish imura S | 2001 | J ClinMicrob2001，32，12： | 1 |
| 11 | Enhancement of activity of sol-gel immobilized lipase in organic media by pretreatment with substrate analogues 显示文摘 | Furukawa S Y Ono T Ijima H | 2001 | Mol Catal B: Enzym2001，15，： | 1 |
| 12 | 显示文摘 | Kaneko M Fukuda J Ijima H | 1998 | Materials Science and Engineering: C1998，6，4： | 1 |
| 13 | Helical microtubules of graphitic carbon 显示文摘 | IJIMA S | 1991 | Nature1991，354，： | 1 |
| 14 | 显示文摘 | Ijima S | 1991 | Nature1991，354，： | 1 |
| 15 | Heparin-conjuga- ted gelatin as a growth factor immobilization scaf- fold显示文摘 | Nakamura S Kubo T Ijima H | 2013 | Journal of Bioscience and Bioengineer- ing2013，115，5： | 1 |
| 16 | In situ gellable oxidized cit- rus pectin for localized delivery of anticancer drugs and preven- tion of homotypic cancer cell aggregation 显示文摘 | Takei T Sato M Ijima H | 2010 | Biomacromole- eules2010，11，12： | 1 |
| 17 | Helical microtubules of graphitic carbon 显示文摘 | Ijima S | 1991 | Nature1991，，354： | 1 |
| 18 | Blood-brain barrier opening following transient reflex sympathetic hypertension显示文摘 | Ijima T Kubota Y Kuroiwa T | 1994 | Acta Neurochir Suppl (Wien)1994，60，： | 1 |
| 19 | Enzymatic synthesis of (R)-flurbiprofen显示文摘 | Terao Y Ijima Y Kakidani H | 2003 | Bull Chem Soc Jpn2003，76，12： | 1 |
| 20 | Helical Microtubules of Graphitic Carbon显示文摘 | Ijima S | 1991 | Nature1991，354，1： | 1 |
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