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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of whey protein purity and glycerol content upon physical properties of edible films manufactu- red therefrom 显示文摘 | Oscar L R Isabel R SaraI S | 2013 | Food Hydrocolloids2013，30，： | 1 |
| 3 | Method to evaluate foaming performance显示文摘 | Anabela R Jose E Isabel S | 1998 | Journal of Food Engineering1998，36，： | 1 |
| 4 | The Immune Microenvironment of Human Tumors: General Significance and Clinical Impact显示文摘 | Wolf-Herman Fridman Marie-Caroline Dieu-Nosjean Franck Pagès Isabelle Cremer Diane Damotte Catherine Sautès-Fridman Jér?me Galon | 2013 | Cancer Microenvironment2013，，2： | 1 |
| 5 | Analysis of octyl - and nonylphenol and their ethoxylates in water and sediments by liquid chromatography/tandem mass spectrometry 显示文摘 | Jorge E L R Isabelle S A Clifford P R | 2003 | Analytical Chemistry2003，75，18： | 1 |
| 6 | Leucine supplementation im- proves muscle protein synthesis in elderly men independently of hy- peraminoacidaemia显示文摘 | Isabelle R Mich~le B Claire S | 2006 | The Journal of Physilolgy2006，575，： | 1 |
| 7 | Reproducibility of blood tests of liver fibrosis in clinical practice显示文摘 | Paul Calès Pascal Veillon Anselme Konaté Elisabeth Mathieu Catherine Ternisien Alain Chevailler Alban Godon Yves Gallois Fran?oise Joubaud Isabelle Hubert-Fouchard Frédéric Oberti Stéphane Réaud Gilles Hunault Fran?oise Mauriat Fran?oise Lunel-Fabiani | 2007 | Clinical Biochemistry2007，，1： | 1 |
| 8 | The Relative Effect of Milk Base, Starter, and Precess on Yogurt Texture显示文摘 | ISABELLE S FLORENT R SAMIA H | 2004 | Critical Reviews in Food Science and Nutrition2004，44，： | 1 |
| 9 | Rhodium(Ⅰ)bis(aminophosphane)complexes as catalysts for asym-metric hydrogenation of activated ketones显示文摘 | ALAIN R ISABELLE S MARC D | 1996 | Tetrahe-dron:Asymmetry1996，7，2： | 1 |
| 10 | 显示文摘 | Cristina S Montserrat R Isabel R | 2003 | Inorg Chem2003，42，： | 1 |
| 11 | Tumor cell budding and laminin-5 expressionin in colorectal carcinoma can be modulated by the tissue micro-environment 显示文摘 | Isabell S Patricia R Pascal C | 2000 | Int J Cancer2000，88，： | 1 |
| 12 | 显示文摘 | Cristina S Isabel R Montserrat R | 2004 | J Am Chem Soc2004，126，： | 1 |
| 13 | Type Ⅲ secretion: The bacteria- eukaryotic cell express显示文摘 | Luis JM Isabel S Guy R | 2005 | FEMS Microbiol Lett2005，252，1： | 1 |
| 14 | Chromosomal polymorphism,morphometric traits and matingsuccess in Leptysma argentina Brunet (Orthoptem) Genetica显示文摘 | Pensel S Isabel R M | 2004 | Genetica2004，121，： | 1 |
| 15 | The effect of phosphate concentration on growth and agar content of Gelidium robustum(Gelideaceae,Rhodophyta) in culture显示文摘 | Isabel S P Lewis R Fuller M P | 1996 | Hydrobiologia1996，，： | 1 |
| 16 | Development and validation of a fast high-performance liquid chromatography method for the determination of microcncapsulated pyrethroid pesticides显示文摘 | ISABEL P R GIL-ALEGRE M E ANA ISABEL T S | 2006 | Analytica Chirnica Acta2006，557，12： | 1 |
| 17 | Effects of ohmic andconventional heating on anthocyanin degradation during the pro- cessing of blueberry pulp 显示文摘 | Julia R S Debora P J Isabel C T | 2013 | LWT- Food Science and Tech- nology2013，51，： | 1 |
| 18 | Acoustic radiation force impulse: a new ultrasonographic technology for the widespread noninvasive diagnosis of liver fibrosis显示文摘 | Jér?me Boursier Gael Isselin Isabelle Fouchard-Hubert Frédéric Oberti Nina Dib Jér?me Lebigot Sandrine Bertrais Yves Gallois Paul Calès Christophe Aubé | 2010 | European Journal of Gastroenterology & Hepatology2010，，9： | 1 |
| 19 | Passivity-based control of nonlinear chemical processes显示文摘 | Hebertt S R Maria Isabel A N | 1997 | International J Control1997，68，5： | 1 |
| 20 | Bacterial cel- lulose membranes as transdermal delivery systems for di- clofenac: In vitro dissolution and permeation studies 显示文摘 | Nuno H C S S Artur F R Isabel F A | 2014 | Carbohydr Polym2014，106，： | 1 |
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