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| 1 | Patient characteristics with high or low blood urea nitrogen in upper gastrointestinal bleeding显示文摘AIM: To examine characteristics of patients with blood urea nitrogen(BUN) levels higher and lower than the normal limit.METHODS: Patient records between April 2011 and March 2014 were analyzed retrospectively. During this time, 3296 patients underwent upper endoscopy. In total, 50 male(69.2 ± 13.2 years) and 26 female(72.3 ± 10.2 years) patients were assessed. Patients were divided into two groups based on BUN levels: higher than the normal limit(21.0 mg/d L)(H) and lower thanthe normal limit(L). One-way analysis of variance was performed to reveal differences in the variables between the H and L groups. Fisher's exact test was used to compare the percentage of patients with gastric ulcer or gastric cancer in the H and L groups.RESULTS: White blood cell count was higher in the H group than in the L group(P = 0.0047). Hemoglobin level was lower in the H group than in the L group(P = 0.0307). Glycated hemoglobin was higher in the H group than in the L group(P = 0.0264). The percentage of patients with gastric ulcer was higher in the H group(P = 0.0002). The H group contained no patients with gastric cancer.CONCLUSION: Patients with BUN ≥ 21 mg/d L might have more severe upper gastrointestinal bleeding. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki Ishige | 2015 | World Journal of Gastroenterology2015，21，24： | 8 |
| 2 | Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse显示文摘AIM: To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS: The multi-herbal medicine Juzentaihoto (JTX) was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins (HSPs) 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite (SA) was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism (T-RFLP) method was used. To identify the changed bacteria, DNA sequencing was performed. RESULTS: Heat shock protein gene expression,documented by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene expression. CONCLUSION: Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver. | Miho Kato Atsushi Ishige Naoko Anjiki Masahiro Yamamoto Yoshifumi Irie Mitsue Taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe | 2007 | World Journal of Gastroenterology2007，13，16： | 5 |
| 3 | Serum magnesium concentration in children with functional constipation treated with magnesium oxide显示文摘AIM:To determine whether hypermagnesemia recently reported in adult patients possibly develops in children with functional constipation taking daily magnesium oxide.METHODS:We enrolled 120 patients (57 male and 63 female) aged 1-14 years old (median:4.7 years) with functional constipation from 13 hospitals and two private clinics.All patients fulfilled the Rome Ⅲ criteria for functional constipation and were treated with daily oral magnesium oxide for at least 1 mo.The median treatment dose was 600 (500-800) mg/d.Patients were assessed by an interview and laboratory examination to determine possible hypermagnesemia.Serum magnesium concentration was also measured in sex-and agematched control subjects (n=38).RESULTS:In the constipation group,serum magnesium concentration [2.4 (2.3-2.5) mg/dL,median and interquartile range] was significantly greater than that of the control group [2.2 (2.0-2.2) mg/dL] (P < 0.001).The highest value was 3.2 mg/dL.Renal magnesium clearance was significantly increased in the constipation group.Serum magnesium concentration in the constipation group decreased significantly with age (P < 0.01).There was no significant correlation between the serum level of magnesium and the duration of treatment with magnesium oxide or the daily dose.None of the patients had side effects associated with hypermagnesemia.CONCLUSION:Serum magnesium concentration increased significantly,but not critically,after daily treatment with magnesium oxide in constipated children with normal renal function. | Maiko Tatsuki Reiko Miyazawa Takeshi Tomomasa Takashi Ishige Tomoko Nakazawa Hirokazu Arakawa | 2011 | World Journal of Gastroenterology2011，17，6： | 4 |
| 4 | Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding显示文摘AIM: To distinguish upper from lower gastrointestinal(GI) bleeding. METHODS: Patient records between April 2011 and March 2014 were analyzed retrospectively(3296 upper endoscopy, and 1520 colonoscopy). Seventysix patients had upper GI bleeding(Upper group) and 65 had lower GI bleeding(Lower group). Variables were compared between the groups using one-way analysis of variance. Logistic regression was performed to identify variables significantly associated with the diagnosis of upper vs lower GI bleeding. Receiveroperator characteristic(ROC) analysis was performed to determine the threshold value that could distinguish upper from lower GI bleeding. RESULTS: Hemoglobin(P = 0.023), total protein(P = 0.0002), and lactate dehydrogenase(P = 0.009) were significantly lower in the Upper group than in the Lower group. Blood urea nitrogen(BUN) was higher in the Upper group than in the Lower group(P = 0.0065). Logistic regression analysis revealed that BUN was most strongly associated with the diagnosis of upper vslower GI bleeding. ROC analysis revealed a threshold BUN value of 21.0 mg/d L, with a specificity of 93.0%.CONCLUSION: The threshold BUN value for distinguishing upper from lower GI bleeding was 21.0 mg/d L. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki Ishige | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 5 | Antinociceptive mechanism of Gosha-Jinki-gan in streptozotocin-induced diabetic animals:role of nitric oxide in the periphery显示文摘 | Suzuki Y Goto K Ishige A | 1999 | Jpn J Pharmacol1999，79，： | 1 |
| 6 | The activition of dopamine D4 receptor inhibits oxidative stress-induced nerve cell death显示文摘 | Ishige K Chen Q Sagara Y | 2001 | J Neurosci2001，21，16： | 1 |
| 7 | Chronic stress induces impairment of spatial working memory because of prefi'ontal dopaminergie dysfunction显示文摘 | Mizoguehi K Yuzurihara M Ishige A | 2000 | J Neurosci2000，20，4： | 1 |
| 8 | Large time behaviors of hot spots for the heat equation with a potential 显示文摘 | ISHIGE K KABEYA Y | 2008 | J Diff Eqs2008，244，11： | 1 |
| 9 | Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction显示文摘 | Mizoguchi K Yuzurihara M Ishige A | 2000 | J Neurosci2000，20，4： | 1 |
| 10 | An evaluation of microencapsulated PCM for use in cold energy transportation medium 显示文摘 | Yamagishi Y Sugeno T Ishige T | 1996 | IEEE1996，，10： | 1 |
| 11 | Supression of T cell proliferation by CD8^+ T cells induced in the presence of protoscolices of Echinococcus muhilocularis in vitro显示文摘 | Kizaki T Ishige M Kobayashi S | 1993 | Infect hnmun1993，61，2： | 1 |
| 12 | Basement membrane matrix modifies cytokine interactions between lung cancer cells and fibroblasts显示文摘 | Akashi T Minami J Ishige Y | 2005 | Pathobiol2005，72，5： | 1 |
| 13 | Generation of CD8^+ suppression T cells by protoscoleces of Echinococcus multilocularis in vitro显示文摘 | Kizaki T Ishige M Bingyan W | 1993 | Immunol1993，79，3： | 1 |
| 14 | Inorganic polyphosphate and polyphosphate kinase: their novel biological functions and applications显示文摘 | Shiba T Tsutsumi K Ishige K | 2000 | Biochevnistry(Mosc)2000，65，3： | 1 |
| 15 | Four - segment classifi- cation of proximal humeral fractures revisited:a multicenter study on 509 cases 显示文摘 | Tamai K Ishige N Kumda S | 2009 | J Shoulder Elbow Surg2009，18，6： | 1 |
| 16 | Acute infection by hepatitis E vi- rus with a slight immunoglobulin M antibody response 显示文摘 | Inagaki Yuki Oshiro Yukio Imanishi Mamiko Ishige Kazunori Takahashi Masaharu Okamoto Hiroaki Ohkohehi Nobuhiro | 2015 | Clinical journal of gastroenterology2015，8，4： | 1 |
| 17 | Distinct nuclear factorkappaB/Rel proteins have opposing modulatory effects in glutamateinduced cell death in HT22 cells显示文摘 | Ishige K Tanaka M Arakawa M | 2005 | Neurochem Int2005，47，8： | 1 |
| 18 | Effects of cyclo- heximide on delayed neuronal death in rat hippocampus 显示文摘 | Goto K Ishige A Sekiguchi K | 1990 | Brain Res1990，534，12： | 1 |
| 19 | Chronic stress differentially regulates glucocorticoid negative feedback response in rats 显示文摘 | Mizoguchi K Yuzuribara M Ishige A | 2001 | J Psychoneuroendocrinology2001，26，3： | 1 |
| 20 | Flavonoids protect neuronal ceils from oxidative stress by three distinct mechanisms显示文摘 | ISHIGE K SCHUBERT D SAGARA Y | 2001 | Free Radic Biol Med2001，30，4： | 1 |
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