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| 1 | Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis显示文摘BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe hypertriglyceridemia.METHODS:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum triglycerides.The APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being taken.The patients' progression,etiological diagnosis,hospital stay and clinical and radiological severity were all recorded.RESULTS:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) origin.Compared with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes mellitus.They usually consumed alcohol or consumed it excessively on the days before admission.Also,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption. | Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos Pedro González-Santos Pedro Valdivielso | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 26 |
| 2 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 3 | Intimal pericytes as the second line of immune defence in atherosclerosis显示文摘Inflammation plays an essential role in the development of atherosclerosis. The initiation and growth of atherosclerotic plaques is accompanied by recruitment of inflammatory and precursor cells from the bloodstream and their differentiation towards pro-inflammatory phenotypes. This process is orchestrated by the production of a number of pro-inflammatory cytokines and chemokines. Human arterial intima consists of structurally distinct leaflets, with a proteoglycan-rich layer lying immediately below the endothelial lining. Recent studies reveal the important role of stellate pericyte-like cells(intimal pericytes) populating the proteoglycan-rich layer in the development of atherosclerosis. During the pathologic process, intimal pericytes may participate in the recruitment of inflammatory cells by producing signalling molecules and play a role in the antigen presentation. Intimal pericytes are also involved in lipid accumulation and the formation of foam cells. This review focuses on the role of pericytelike cells in the development of atherosclerotic lesions. | Ekaterina A Ivanova Yuri V Bobryshev Alexander N Orekhov | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 4 | Cylindrical GaAs quantum wires incorporated within chrysotile asbestos nanotubes : Fabrication and polarized optical absorption spectra显示文摘 | Poborchii V V Ivanova M S Salamatina I A | 1994 | Superlattices and Microstructures1994，16，2： | 1 |
| 5 | Formation and Investigation of Sol-Gel TiO2-V2O5 System 显示文摘 | Ivanova T Harizanova A Surtchev M | 2002 | Materials Letters2002，55，5： | 1 |
| 6 | Transesterification of rapeseed oil under fiow conditions catalyzed by basic solids: M - AI(La) -O (M =Sr, Ba), M-Mg-O (M=Y, La) 显示文摘 | SHERSTYUK O V IVANOVA A S LEBEDEV M Y | 2012 | Appl Catal A- Gen2012，，： | 1 |
| 7 | Alternative splicing of cGMP-dependent protein kinase I in angiotensin - hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle 显示文摘 | GERZANICH V IVANOV A IVANOVA S | 2003 | Circ Res2003，93，： | 1 |
| 8 | Study of sol-gel TiO2 and TiO2-MnO obtained from a peptized solution 显示文摘 | HARIZANOV O IVANOVA T HARIZANOVA A | 2001 | Materials Let- ters2001，49，34： | 1 |
| 9 | Superhydrophobic ehitosan-based coatings for textile processing 显示文摘 | Ivanova N A Philipchenko A B | 2012 | Ap- plied Surface Science2012，263，： | 1 |
| 10 | Time history of gain calculations in radiative-collisional model for X-ray lasers显示文摘 | Ivanova E P Zinoviev N A | 2001 | Journal De Physique2001，11，7： | 1 |
| 11 | Chalcone synthase gene from Antir-rhinum majus in antisen-se orientation successfully suppressed the petals pigmentation of chrysanthemum显示文摘 | MITIOUCHKINA T Y IVANOVA E P TARAN S A | 2000 | Acta HoDmrtic2000，508，： | 1 |
| 12 | 2-distance A + 2-coloring of planar graphs with girth six and A(G) 18 显示文摘 | BORODIN O V IVANOVA A O | 2009 | Discrete Mathematics2009，309，： | 1 |
| 13 | Spatial distribution of resting stages(akinetes)of the cyanobacteria Anabaena flos-aquae in sediments and its influence on pelagic populations显示文摘 | Kravchuk E S Ivanova E A Gladyshev M I | 2011 | Marine and Freshwater Research2011，62，5： | 1 |
| 14 | Endogenous hormone levels during direct somatic embryogenesis in Medicago falcata显示文摘 | Ivanova A Velcheva M Denchev P | 1994 | Physiologia Plantarum1994，92，： | 1 |
| 15 | Results of the trial of the microbiological method for the enhancement of oil recovery at the carbonate collector of the romashkinskoe oil field biogeo-chemical and productional characteristics显示文摘 | Nazina T N Ivanova A E Ivoilov V S | | 0，，02： | 1 |
| 16 | Low-dose IL-2 therapy reduces HCV RNA and HBV DNA:case report显示文摘 | Tomova R Antonov K Ivanova A | 2009 | Anticancer Res2009，29，12： | 1 |
| 17 | 2-distance △+2-coloring of planar graphs with girth six and △(G)≥18显示文摘 | Borodin O V Ivanova A O | 2009 | Discrete Mathematics2009，309，： | 1 |
| 18 | Fractal fracture mechanics-A review 显示文摘 | Cherepanoy G P Balankin A S Ivanova V S | 1995 | Engineering Fracture Mechanics1995，51，6： | 1 |
| 19 | Fractal fracture mechanics-a review显示文摘 | CHEREPANOY G P BALANKIN A S IVANOVA V S | 1995 | Engineering Fracture Me- chanics1995，51，6： | 1 |
| 20 | The structural instability of transonic flow associated with amalgamation/splitting of supersonic regions 显示文摘 | Kuz'min A G Ivanova A V | 2004 | Fluid Dynamics2004，18，5： | 1 |
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