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| 1 | Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia显示文摘AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(PE)outcomes.METHODS:Liver specimens were obtained at PE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and CD34.Liver biopsies from 35 organ donors were used as controls.Expression patterns were related to clinical data including age at PE,serum total and conjugated bilirubin concentration at the time of PE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological findings.RESULTS:Collagen 1(16.4%vs 4.5%,P<0.0001),α-SMA(17.9%vs 4.6%,P<0.0001)and CD34(4.9%vs 3.8%,P=0.017)were markedly overexpressed in BA patients compared with controls.Patients who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,P=0.024),α-SMA(20.4%vs 15.4%,P=0.009)and CD34(5.9%vs 4.0%,P=0.029)at PE compared with native liver survivors.CD34-positive microvessels were identified in the centrizonal region close to central vein in every BA patient.In majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic lobules.In controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the rest.The difference between BA patients and controls was significant(P<0.0001).Patients who developed esophageal varices by two years had significantly higher expression of CD34 at PE compared with patients without varices(5.6%vs 4.0%,P=0.019).Expression ofα-SMA(r=0.758,P<0.0001)and collagen 1(r=0.474,P=0.016),and the amount of CD34-positive microvessels(r=0.356,P=0.047)were related to patient age at PE.CONCLUSION:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasing PE age and relate to native liver survival and development of esophageal varices. | Janne S Suominen Hanna Lampela Pivi Heikkil Jouko Lohi Hannu Jalanko Mikko P Pakarinen | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 2 | Leupeptin causes an accumulation d lipofusein-like substances and other sigas of aging in kidneysyoung rats: fitrther eviddmee for the protease inhibitar modal d aging显示文摘 | Ivy GO Roopeingh R KAnai S | 1996 | Ann N Y Acad Sci1996，786，： | 1 |
| 3 | A modeling approach to maintenance decisions using statistical quality control and optimization显示文摘 | IVY J S NEMBHARD H B | 2005 | Quality and Reliability Engineering International2005，21，4： | 1 |
| 4 | Resilience:Enhancing well-being through positive cognitive triad显示文摘 | Mak W Ivy S W Wong C Y | 2011 | Journal of Counseling Psychology2011，58，4： | 1 |
| 5 | Initial experience with tadalafil in pediatric pulmonary arterial hypertension 显示文摘 | Takatsuki S Calderhank M Ivy DD | 2012 | Pediatr Cardiol2012，33，5： | 1 |
| 6 | Inorganic Nitrite and Nitrate: Evidence to Support Consideration as Dietary Nutrients显示文摘 | Bryan N S Ivy J L | 2015 | Nutritionreseareh2015，35，8： | 1 |
| 7 | Effects of alpha7 positive al- losterie modulators in murine inflammatory and chronic neuropathic pain models显示文摘 | Freitas K Ghosh S Ivy Carroll F | 2013 | Neuropharmacology2013，65，： | 1 |
| 8 | ferentia| diag- nosis and management o Iocal ground-glass opacities显示文摘 | IVI Infante RF Lutman S Imparatot | 2009 | Eur Respir J2009，33，821： | 1 |
| 9 | B-type natriuretic peptide and a- mino-terminal pro-B-type natriuretic peptide in pediatric patients with pulmonary arterial hypertension 显示文摘 | Takatsuki S Wagner BD Ivy DD | 2012 | Congenit Heart Dis2012，7，3： | 1 |
| 10 | Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin显示文摘 | Keezer S M Ivie S E Krutzsch H C | 2003 | Cancer Research2003，63，： | 1 |
| 11 | Serf - assembly of surfactant vesicles that transform into viscoelastic wormlike micelles upon heating 显示文摘 | DAVIES T S KETNER A iVI RAGHAVAN S R | 2006 | Journal of the American Chemical Society2006，128，20： | 1 |
| 12 | Induction of a heat shockgene at the site of tissue injury in the rat brain显示文摘 | Brown I R Rush S J Ivy G O | 1989 | Neuron1989，2，： | 1 |
| 13 | Inorganic nitrite and nitrate:evidence to support consideration as dietary nutrients显示文摘 | Bryan N S Ivy J L | 2015 | Nutrients Research2015，35，8： | 1 |
| 14 | Is there a difference? A prospective study comparing lateral and standard SMAS face lifts with extended SMAS and composite rhytidectomies显示文摘 | IVY E J LORENC Z P ASTON S J | 1996 | Plast Reconstr Surg1996，98，7： | 1 |
| 15 | Deoxygenation of dodecanoic acid under inert atmosphere显示文摘 | Heidi Bernas Kari Er?nen Irina Simakova Anne-Riikka Leino Krisztián Kordás Jukka Myllyoja P?ivi M?ki-Arvela Tapio Salmi Dmitry Yu. Murzin | 2009 | Fuel2009，，8： | 1 |
| 16 | LiBH4 in carbon aerogel nanoseaffolds: an NMR study of atomic motions显示文摘 | David T S Robert L C Charlie IVI' | 2010 | Journal of Physi cal Chemistry C2010，114，9： | 1 |
| 17 | Lactose modifications enhance its drug performance in the novel multiple dose Taifun DPI 显示文摘 | Pa ivi H Vesa- Pekka L Krista M Eero S Tapio L Petteri P Kristiina J | 2002 | European Journal of Pharmaceutical Sciences2002，16，： | 1 |
| 18 | Risk factors associated with pelvic floor disorders in women undergoing surgical repair显示文摘 | MOALLI P A JONES IVY S MEYN L A | 2003 | Obstet Gynecol2003，101，51： | 1 |
| 19 | B-type natriuretic peptide and amino-terminal pro-B-type natriuretie peptide in pediatric patients with pulmonary arterial hypertension 显示文摘 | Takatsuki S Wagner BD Ivy DD | 2012 | Congenit Heart Dis2012，7，3： | 1 |
| 20 | Molecular conversations and the development of the hair follicle and basal cell carcinoma显示文摘 | Harris P J Takebe N Ivy S P | 2010 | Cancer Prev Res(Phila)2010，3，10： | 1 |
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