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	题名	作者	年代	出处	被引量
1	Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy.	Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi	2016	World Journal of Gastroenterology2016，22，44：	5
2	Molecular genetics of febrile seizures 显示文摘	Iwasaki N O Nakayama J U	2002	Epilepsia2002，43，9：	1
3	Image Retrieval usings patial intensity features 显示文摘	TAKAHASHI N IWASAKI M KUNIEDA T	2000	Signal Processing: Image Communication2000，，16：	1
4	Two-and threebody wear of composite resins显示文摘	Koottathape N Takahashi H Iwasaki N	2012	Dent Mater2012，28，12：	1
5	Metaplastic carcinoma of the breast显示文摘	Okada N Hasebe T Iwasaki M	2010	Hum Pathol2010，41，7：	1
6	Three - dimensional helical computed tomographic angiography in obstructed total anomalous pulmonary venous drainage 显示文摘	Shiraishi I Yamagishi M Iwasaki N	2001	Ann Thorac Surg2001，71，7：	1
7	Ultrahigh cell density culture of a marine green alga, Chlorococcum littorale in a flat plate photobioreactor显示文摘	Kurano N Iwasaki I Kawachi M and Miyachi S	1998	Appl Microbiol Biot1998，49，：	1
8	Genetic polymorphisms in estrogen metabolism and breast cancer risk in case-control studies in Japanese,Japanese Brazilians and non-Japanese Brazilians显示文摘	SHIMADA N IWASAKI M KASUGA Y		0，，04：	1
9	Beta-cell transcription factors and diabetes : no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEU2ROD4) in Japanese patients with MODY 显示文摘	Horikawa Y Cox N J Iwasaki N	2000	Diabetes2000，49，：	1
10	Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation 显示文摘	Nagata N Iwasaki T Ami Y	2004	J Gen Virol2004，85，10：	1
11	Cervical spondylotic radiculop- athy involving two adjacent nerce roots: anterior decompression through a single lecel intervertebral approach 显示文摘	Iwasaki M Okadak Tsumaki N	1996	Int Orthop1996，20，2：	1
12	Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71 显示文摘	Nagata N Shimizu H Ami Y Tano Y Harashima A Suzaki Y Sato Y Miyamura T Sata T Iwasaki T	2002	J Med Virol2002，67，2：	1
13	Expression of vascular endothelial growth factor and E-cadherin in human ovarian cancer:association with ascites fluid accumulation and peritoneal dissemination in mouse ascites model显示文摘	AKUTAGAWA N NISH1KAWA A IWASAKI M	2002	Jpn J Cancer Res2002，93，：	1
14	Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat′s spatial cognition in eight-armed radial maze test显示文摘	Hatip-Al-Khatib I Egashira N Mishima K Iwasaki K Iwasaki K Kurauchi K	2004	J Pharmacol Sci2004，96，1：	1
15	Image retrieval using spatial intensity features 显示文摘	Takahashi N Iwasaki M Kunieda T	2000	Signal Processing: Image Communication2000，16，12：	1
16	Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia显示文摘	Hasegawa I Niisato N Iwasaki Y	2006	Biochem Biophys Res Commun2006，343，2：	1
17	Comprehensive diagnostic bronchoscopy of central type early stage lung cancer显示文摘	IKeda N Hayashi A Iwasaki K	2007	Lung Cancer2007，56，2：	1
18	Translucency of dental ceramics with different thicknesses显示文摘	Wang F Takahashi H Iwasaki N	2013	J Prosthet Dent2013，110，1：	1
19	Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation 显示文摘	Nagata N Iwasaki T Ami Y Tano Y Harashima A Suzaki Y Sato Y Hasegawa H Sata T Miyamura T Shimizu H	2004	J Gen Virol2004，85，10：	1
20	Translucency of dental ceramics with different thicknesses显示文摘	Wang F Takahashi H Iwasaki N	2013	J Prosthet Dent2013，110，1：	1

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