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| 1 | Chronic obstructive pulmonary disease as a risk factor for lung cancer显示文摘The association between chronic obstructive pulmonary disease(COPD) and lung cancer has long been a subject of intense debate. The high prevalence of COPD in elderly smokers inevitably strengthens their coincidence. In addition to this contingent coincidence, recent studies have revealed a close association between the two diseases that is independent of the smoking history; that is, the existence of COPD is an independent risk factor for the development of lung cancer. Molecular-based evidence has been accumulating as a result of the efforts to explain the underlying mechanisms of this association. These mechanisms may include the following: the retention of airborne carcinogens followed by the activation of oncogenes and the suppression of tumor suppressor genes; the complex molecular mechanism associated with chronic inflammation in the distal airways of patients with COPD; the possible in-volvement of putative distal airway stem cells; and gel netic factors that are common to both COPD and lung cancer. The existence of COPD in patients with lung l cancer may potentially affect the process of diagnosis, surgical resection, radiotherapy, chemotherapy, and end-of-life care. The comprehensive management of COPD is extremely important for the appropriate treatment of lung cancer. Surgical resections with the aid of early interventions for COPD are often possible, even for patients with mild-to-moderate COPD. New challenges, such as lung cancer CT screening for individuals t at high risk, are now in the process of being implemented. Evaluating the risk of lung cancer in patients with COPD may be warranted in community-based lung cancer screening. | Yuichi Takiguchi Ikuo Sekine Shunichiro Iwasawa Ryota Kurimoto Koichiro Tatsumi | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 2 | Acute development of collateral circulation and therapeutic prospects in ischemic stroke显示文摘In acute ischemic stroke,collateral circulation plays an important role in maintaining blood flow to the tissue that is at risk of progressing into ischemia,and in increasing the successful recanalization rate without hemorrhagic transformation.We have reported that well-developed collateral circulation is associated with smaller infarct volume and better long-term neurological outcome,and it disappears promptly once the effective recanalization is achieved.Contrary to the belief that collateral vessels develop over time in chronic stenotic condition,there exists a phenomenon that collateral circulation develops immediately in acute stenosis or occlusion of the arteries and it seems to be triggered by fluid shear stress,which occurs between the territories of stenotic/occluded arteries and those fed by surrounding intact arteries.We believe that this acute development of collateral circulation is a target of novel therapeutics in ischemic stroke and refer our recent attempt in enhancing collateral circulation by modulating sphingosine-1-phosphate receptor 1,which is a known shear-stress mechanosensing protein. | Eri Iwasawa Masahiko Ichijo Satoru Ishibashi Takanori Yokota | 2016 | Neural Regeneration Research2016，11，3： | 19 |
| 3 | 3D attitude measurement by means of spread spectrum modulated ultrasonic wave显示文摘Local position and attitude measurement methods are necessary for the navigation of autonomous robots and the other applications. In this paper, a 3D attitude measurement method is proposed. This method uses the spread spectrum modulated ultrasonic wave for the measurement of the pseudo-distance of each pathway between transmitter and receiver elements that are arranged in an array. The relative attitude between transmitter and receiver unit could be calculated from the relationship between these pseudo-distances. The use of spread spectrum modulation enables the high accuracy, noise tolerance, and coexistence of multiple transmitter devices by code division multiple access (CDMA) between transmitter and receiver elements. A pair of transmitter and receiver prototype for proposed method was manufactured, and the fundamental performance was examined in experiments. As a result, accuracy of σ=0.78 mm in the pseudo-distance measurement of each pathway between transmitter and receiver elements was confirmed, and about 0.01 rad resolution in the attitude measurement was also confirmed. | Shinji Ohyama Hiroshi Iwasawa Sang Il Ko Junya Takayama | 2007 | 仪器仪表学报2007，28，4： | 2 |
| 4 | Human papillornavicus DNA in urine specimens of men with condyloma acuminatum显示文摘 | Iwasawa A Hiltunen-Back E Reunela T | 1997 | Sex Transm Dis1997，24，3： | 1 |
| 5 | Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts显示文摘 | NAGASE Y IWASAWA M AKIYAMA T | 2009 | J Biol Chem2009，284，36： | 1 |
| 6 | In vivo examination of strong acidic electrolyzed water, povidone-iodine, chlorhexi-dine and benzalkonium chlo- ride显示文摘 | Iwasawa A Nakamura Y Cytotoxic effect of anti-septics: com- parison In vitro | 2003 | Kansenshogaku Zasshi2003，77，5： | 1 |
| 7 | 查看详情显示文摘 | Minamikawa H Hayakawa S Yamada T Iwasawa N Narasaka K | | 0，，： | 1 |
| 8 | Clinical and genetic studies of Japanese homozygotes disease L444P muta- tion显示文摘 | IDA H RENNERT O M IWASAWA K | 1999 | Hum Genet1999，105，12： | 1 |
| 9 | Phase Ⅱ study of car- boplatin, docetaxel and bevacizumab for chemotherapy-nive pa- tients with advanced non-squamous non-small cell lung cancer 显示文摘 | Takiguchi Y Iwasawa S Minato K | 2015 | Int J Clin Oncol2015，20，4： | 1 |
| 10 | Detection of human Papillomavirus deoxyribonucleic acid in penile carcinoma by polymerase chain reaction and in situ hybridization显示文摘 | Kumamoto Y Fujinaga K | 1993 | J Urol1993，149，1： | 1 |
| 11 | Fisl and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction显示文摘 | Iwasawa R Mahul-Mellier AL Datler C | 2011 | EMBO J2011，30，3： | 1 |
| 12 | Acid-base bifunctional catalytic surfaces for nucleophilic addition reactions 显示文摘 | MOTOKURA K TADA M IWASAWA Y | 2008 | Chemistry-An Asian Journal2008，3，89： | 1 |
| 13 | Transient studies on carbon monoxide over supported gold catalysts: Support effeets显示文摘 | Olea M Iwasawa Y | 2004 | Appl Catal A: Gen2004，275，： | 1 |
| 14 | Selective oxidation of benzene to phenol with molecular oxygen on rhenium/zeo- lite catalysts显示文摘 | Kusakari T Sasaki T Iwasawa Y | 2004 | Chem Commun2004，，8： | 1 |
| 15 | Electronic structure, Dirac points and Fermi arc surface states in three-dimensional Dirac semimetal Na_3Bi from angle-resolved photoemission spectroscopy显示文摘The three-dimensional(3D) Dirac semimetals have linearly dispersive 3D Dirac nodes where the conduction band and valence band are connected. They have isolated 3D Dirac nodes in the whole Brillouin zone and can be viewed as a 3D counterpart of graphene. Recent theoretical calculations and experimental results indicate that the 3D Dirac semimetal state can be realized in a simple stoichiometric compound A3Bi(A = Na, K, Rb). Here we report comprehensive high-resolution angle-resolved photoemission(ARPES) measurements on the two cleaved surfaces,(001) and(100), of Na3Bi. On the(001) surface, by comparison with theoretical calculations, we provide a proper assignment of the observed bands, and in particular, pinpoint the band that is responsible for the formation of the three-dimensional Dirac cones. We observe clear evidence of 3D Dirac cones in the three-dimensional momentum space by directly measuring on the kx–ky plane and by varying the photon energy to get access to different out-of-plane kzs. In addition, we reveal new features around the Brillouin zone corners that may be related with surface reconstruction. On the(100) surface, our ARPES measurements over a large momentum space raise an issue on the selection of the basic Brillouin zone in the(100) plane. We directly observe two isolated 3D Dirac nodes on the(100) surface. We observe the signature of the Fermi-arc surface states connecting the two 3D Dirac nodes that extend to a binding energy of 150 me V before merging into the bulk band. Our observations constitute strong evidence on the existence of the Dirac semimetal state in Na3Bi that are consistent with previous theoretical and experimental work. In addition, our results provide new information to clarify on the nature of the band that forms the3 D Dirac cones, on the possible formation of surface reconstruction of the(001) surface, and on the issue of basic Brillouin zone selection for the(100) surface. | 梁爱基 陈朝宇 王志俊 石友国 冯娅 伊合绵 谢卓晋 何少龙 何俊峰 彭莹莹 刘艳 刘德发 胡成 赵林 刘国东 董晓莉 张君 M Nakatake H Iwasawa K Shimad M Arita H Namatame M Taniguchi 许祖彦 陈创天 翁红明 戴希 方忠 周兴江 | 2016 | Chinese Physics B2016，25，7： | 1 |
| 16 | Aging characteristics and tensile properties of Mg-Gd-Nd-Zr alloys显示文摘 | NEGISHI Y NISHIMURA T IWASAWA S | 1994 | Light Metals1994，44，10： | 1 |
| 17 | Microscopic intraosseous extension of ostensarcoma:assessment on dynamic enhanced MRI显示文摘 | Iwasawa T Tanaka Y Aida N | 1997 | Skeletal Radiol1997，26，4： | 1 |
| 18 | Cystathionine beta-synthase,a key enzyme for homocysteine metabolism,is preferentially expressed in the radial glia/astrocyte lineage of developing mouse显示文摘 | Yasushi Enokido Eri Suzuki Kazu Iwasawa | 2009 | FASEB J2009，19，13： | 1 |
| 19 | 显示文摘 | Klyotaka Asakura Yasuhiro Iwasawa | 1991 | J Phys Chem1991，95，10： | 1 |
| 20 | Pathophysiological role of endothelin in ectopic ossification of human spinal ligaments induced by mechanical stress显示文摘 | Iwasawa T Iwasaki K Sawada T | 2006 | Calcif Tissue Int2006，79，6： | 1 |
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