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| 1 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 2 | Bayesian variable selection for proportionalhazards models 显示文摘 | Ibrahim J G Chen M H Maceachern S N | 1999 | The Canadian Journal of Statists1999，27，4： | 1 |
| 3 | mtDNA phylo geography and postglacial patterns of subdivision in the meadow grasshopper Chorthippus parallelus显示文摘 | Lunt D H Ibrahim K M Hewitt G M | 1998 | He redity1998，80，： | 1 |
| 4 | Cord blood re-sistin and adiponectin in term newborns of diabetic moth-ers显示文摘 | Mohamed M H Gad G I Ibrahim HY | 2010 | Arch Med Sci2010，6，4： | 1 |
| 5 | A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting显示文摘 | IBRAHIM E H WARD S SHERMAN G | 2000 | Chest2000，117，5： | 1 |
| 6 | Fixed and Random Effects Selection in Mixed Effects Models显示文摘 | Ibrahim J G Zhu H Garcia R L | 2011 | Biometrics2011，，2： | 1 |
| 7 | Level of kidney func- tion as a risk factor for atherosclerotic cardiovascular disease in the com- munity 显示文摘 | Manjunath G Tighiouart H Ibrahim H | 2003 | J Am Coil Cardiol2003，41，1： | 1 |
| 8 | Interleukin-18 gene polymorphisms in Egyp- tian patients with allergic diseases显示文摘 | IBRAHIM G H ELTABBAKH M T GOMAA A H | 2012 | Am J Rhinol Allergy2012，26，： | 1 |
| 9 | On optimality properties of the power prior显示文摘 | Ibrahim J G Chen M H Sinha D | 2003 | Journal of the American Statistical Association2003，98，： | 1 |
| 10 | Bayesian Criterion Based Model Assessment for Categorical Data显示文摘 | Chen M H Dey D K Ibrahim J G | 2004 | Biometrika2004，91，： | 1 |
| 11 | Power prior distributions for regression models显示文摘 | Ibrahim J G Chen M H | 2000 | Statistical Science2000，15，： | 1 |
| 12 | Level of kidney func- tion as a risk factor for atherosclerotic cardiovascular outcomes in the community 显示文摘 | Manjunath G Tighiouart H Ibrahim H | 2003 | J Am CoU Cardiol2003，41，： | 1 |
| 13 | Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community显示文摘 | Manjunath G Tighiouart H Ibrahim H | 2003 | J Am Coil Cardiol2003，41，1： | 1 |
| 14 | Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community 显示文摘 | Manjunath G Tighiouart H Ibrahim H | 2003 | J Am Coll Cardiol2003，41，： | 1 |
| 15 | Level of kidney function as a risk factor atherosclerotic cardiovascular out- comes in the community显示文摘 | Manjunath G Tighiouart H Ibrahim H | 2003 | J Am Coll Cardiol2003，41，1： | 1 |
| 16 | Automatic Discovery and Composition of Semantic Web Services Using Al Planning and Web Service Modeling Ontology显示文摘 | Tabatabaei S G H Kadir W M N Ibrahim S | | 0，，01： | 1 |
| 17 | Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community显示文摘 | Manjunath G Tighiouart H Ibrahim H | 2003 | J Am Coll Cardiol2003，41，： | 1 |
| 18 | Sample size and power determination in joint modeling of longitudinal and survival data 显示文摘 | Chert L M Ibrahim I G Chu H | 2011 | Stat Med2011，30，18： | 1 |
| 19 | Missing responses in generalized linear mixed models when the missing data mechanism is nonignomble显示文摘 | IBRAHIM J G CHEN M H LIPSITZSR | 2001 | Biometri- ka2001，88，： | 1 |
| 20 | The role of measuremen! of serum autoantibodies in predietion of pediatric neuropsychiatric systemic lupus erythematosus显示文摘 | Mostafa G A Ibrahim D H Shehab A A | 2010 | J Neuroimmunol2010，227，12： | 1 |
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