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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 3 | 生物多样性保护规划与旅游一体化显示文摘在开发与实施国家生物多样性战略和行动计划的工作中,联合国环境规划署/联合国开发计划署/全球环保基金会“生物多样性规划扶持计划”(BPSP)对国家生物多样性保护规划者提供帮助.“生物多样性规划扶持计划”专门研究旅游中生物多样性方方面面的一体化,重心是要把“全球最佳实践”贯彻到这些战略与行动规划中去.本文重点介绍了哥斯达黎加、南非、伯利兹和其他国家的生态旅游. | HéctorCeballos-Lascuráin 徐鹏 | 2002 | 产业与环境2002，24，3： | 4 |
| 4 | 农业法的全球性挑战与回应显示文摘农业面临着全球化不断推进、粮食安全和食品质量保证、世界人口增加、全球环境问题四方面的挑战。农业法有必要对此予以回应,为可持续农业发展创建具有强制力和可靠性的法律框架,支持和保障农民务农知识的提高和农业科技的发展,对第三次农业革命进行法律调整,解决全球农业法支离破碎的问题。由于农业全球化,硬法和软法在多层次的农业法体系中作用重要,食品安全不仅需要国内法规范,还需要构建国际规范。行之有效的全球食品安全法律体系尚未形成,应该建立对全球粮食安全具有约束力的目标和原则。对中德法律制度进行比较研究,不仅有利于这一法律体系的构建,还有助于克服全球农业法的支离破碎。 | Ines Hrtel 李玉梅 | 2014 | 中国农业大学学报(社会科学版)2014，31，4： | 3 |
| 5 | Effect on hepatitis B virus DNA levds in children infected with different genotypes显示文摘 | Sangfelt P Norder H Magnius LO Interferon - alpha 2b treament in hepatitis B carriers | 1997 | Acta Paediatr1997，86，2： | 1 |
| 6 | A clinicl pathologic study in the elderly显示文摘 | Yamanouchi H Nagura H Mizutani T et ah Embolic brain infarc- tion in nonrheumatic atrial fibrillation | 1997 | Neurology1997，48，6： | 1 |
| 7 | Posterior reversibleencephalopathy syndrome (PRES):Features on CT and MRimaging显示文摘 | Hugonnet E Da Ines D Boby H | 2012 | Diagn Interv Imaging2012，94，1： | 1 |
| 8 | Guidelines forirradiation of blood and blood component post-trans-fusion graft-vs-host disease in Japan显示文摘 | ASAIL T IN ABA S’OHTO H | 2000 | Transfusion2000，10，： | 1 |
| 9 | 2显示文摘 | EVANS H K WYLIE A A MURPHY S K et akThe neuronatin gene resides in a micro-imprinted domain on human chromosome 20ql 1 | 2001 | Genomics2001，77，12： | 1 |
| 10 | Atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus 显示文摘 | Haque S Mirjafari H Bruce IN | 2008 | Curr Opin Lipidol2008，19，4： | 1 |
| 11 | Ultrasonography screening in 96, 278 unselected employees 显示文摘 | Reiners C Wegscheider K Schicha H Prevalence of thyroid disorders in the working population of Germany | 2004 | Thyroid2004，14，11： | 1 |
| 12 | Selective blockage of in-termediate-Conductance Ca2+-Activated K+Channel sup-presses proliferation of microvascular and macrovascular en-dothelial cells and angiogenesis in vitro显示文摘 | Ivica G Ines E Philipp H | 2005 | ArteriosclerosisThromb Vasc Biol2005，25，： | 1 |
| 13 | Corrigendum to mathematics and computa- tion 显示文摘 | KWON 0 M PARKJ H published papers in applied LEE S M | 2009 | Applied Mathematics and Computation2009，215，1： | 1 |
| 14 | Fatal mumps ne- phritis and myocarditis 显示文摘 | Kabaku? N Aydino?lu H Yekeler H Arslan IN etal | 1999 | Journal of Tropical Pediatrics1999，45，6： | 1 |
| 15 | On the mechanism of re- sistance to diclofop-methyl 显示文摘 | HOLTUM JAM MATTHEWS JM H USLER RE et aL Cross-resistance to herbicides in annual ryegrass (LoLium rigidum) Ⅲ | 1991 | Plant Physiol1991，97，： | 1 |
| 16 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 17 | Performance of rotating spray plate sprinklers in indoor experiments显示文摘 | Sourell H Faci J M Play in E | 2003 | Journal of Irrigation and Drainage Engineering2003，129，5： | 1 |
| 18 | Lipid production by Lipomyces starkeyi cells in glucose solution without auxiliary nutrients显示文摘 | L in J Shen H Tan H etal | 2011 | J Biotechnol2011，152，4： | 1 |
| 19 | Urinary diversion 显示文摘 | World Health Organization (WHO) Conference in Bladder Cancer Hautmann RE Abol-Enein H Hafez K Haro I Mansson W Mills RD Montie JD Sagalowsky AI Stein JP Stenzl A Studer UE Volkmer BG | 2007 | Urology2007，，： | 1 |
| 20 | Phase I/II study of adoptive with zoledronic acid and IL-2 to pa- tients with advanced renal cell carcinoma 显示文摘 | Kobayashi H Tanaka Y Yagi J transfer of γδT cells in combination | 2011 | Cancer Immunol lmmu nother2011，60，8： | 1 |
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