|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chemotherapy of glioblastoma in rats using doxorubicin - loaded nanoparticles显示文摘Glioblastomas belong to the most aggressive human cancers with short survival times.Due to the blood-brainbarrier,they are mostly inaccessible to traditional chemotherapy.We have recently shown that doxorubicin boundto polysorbate-coated nanoparticles crossed the intact blood-brain barrier,thus reaching therapeutic concentra-tions in the brain.Here,we investigated the therapeutic potential of this formulation of doxorubicin in vivo using ananimal model created by implantation of 101/8 glioblastoma tumor in rat brains.Groups of 5-8 glioblastoma- | Steiniger SC Kreuter J Khalansky AS Skidan IN Bobruskin I Smirnova ZS Severin SE Uhl R Kock M Geiger KD Gelperina SE | 2004 | 中国神经肿瘤杂志2004，2，1： | 13 |
| 2 | Endoscopic findings in patients with Schatzki rings:Evidence for an association with eosinophilic esophagitis显示文摘AIM:To investigate endoscopic findings in patients with Schatzki rings(SRs) with a focus on evidence for eosinophilic esophagitis(EoE).METHODS:We consecutively approached all adult patients scheduled for elective outpatient upper endoscopy for a variety of indications at the German Diagnostic Clinic,Wiesbaden,Germany between July 2007 and July 2010.All patients with endoscopically diagnosed SRs,defined as thin,symmetrical,mucosal structures located at the esophagogastric junction,were prospectively registered.Additional endoscopic findings,clinical information and histopathological findings with a focus on esophageal eosinophilia(≥ 20 eosinophils/high power field) were recorded.The criteria for active EoE were defined as:(1) eosinophilic tissue infiltration ≥ 20 eosinophils/hpf;(2) symptoms of esophageal dysfunction;and(3) exclusion of other causes of esophageal eosinophilia.Gastroesophageal reflux disease was excluded by proton pump inhibitor treatment prior to endoscopy.The presence of ≥ 20 eosinophils/hpf in esophageal biopsies in patients that did not fulfil the criteria of EoE was defined as esophageal hypereosinophilia.RESULTS:A SR was diagnosed in 171(3.3%;128 males,43 females,mean age 66 ± 12.9 years) of the 5163 patients that underwent upper gastrointestinalendoscopy.Twenty of the 116 patients(17%) from whom esophageal biopsies were obtained showed histological hypereosinophilia(≥ 20 eosinophils/hpf).Nine of these patients(8 males,1 female,mean age 49 ± 10 years) did not fulfill all diagnostic criteria of EoE,whereas in 11(9%) patients with ≥ 20 eosinophils/hpf,a definite diagnosis of EoE was made.Three of the 11 patients(27%) with definite EoE had no suspicious endoscopic features of EoE.In contrast,in the 25 patients in whom EoE was suspected by endoscopic features,EoE was only confirmed in 7(28%) patients.Patients with EoE were younger(mean age 41.5 ± 6.5 vs 50.5 ± 11.5 years,P = 0.012),were more likely to have a history of allergies(73% vs 29%,P = 0.007) and complained more often of dysphagia(91% vs 34%,P = 0.004) and food impaction(36% vs 6%,P = 0.007) than patients without EoE.Endoscopically,additional webs were found significantly more often in patients with EoE than in patients without EoE(36% vs 11%,P = 0.04).Furthermore,the SR had a tendency to be narrower in patients with EoE than in those without EoE(36% vs 18%,P = 0.22).The percentage of males(73% vs 72%,P = 1.0) and frequency of heartburn(27% vs 27%,P = 1.0) were not significantly different in both groups.The 9 patients with esophageal hypereosinophilia that did not fulfil the diagnostic criteria of EoE were younger(mean age 49 ± 10 years vs 58 ± 6 years,P = 0.0008) and were more likely to have a history of allergies(78% vs 24%,P = 0.003) than patients with < 20 eosinophils/hpf.Predictors of EoE were younger age,presence of dysphagia or food impaction and a history of allergies.CONCLUSION:A significant proportion of patients with SRs also have EoE,which may not always be suspected according to other endoscopic features. | Michaela Müller Alexander J Eckardt Annette Fisseler-Eckhoff Susanne Haas Ines Gockel Till Wehrmann | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 3 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 4 | Comparison of fixed and rotating spray plate sprinklers显示文摘 | Faci J M Salvador R Play in E | 2001 | Journal of Irrigation and Drainage Engineering2001，127，4： | 1 |
| 5 | , manipulation of insulin-like growth factor binding protein-3 levels显示文摘 | CHEUNG C W TAYLOR P J KIRKPATRICK C M et aL Therapeutic value of orally administered silibinin in renal cell carcinoma | 2007 | Br J Urol Inter2007，100，2： | 1 |
| 6 | Performance of rotating spray plate sprinklers in indoor experiments显示文摘 | Sourell H Faci J M Play in E | 2003 | Journal of Irrigation and Drainage Engineering2003，129，5： | 1 |
| 7 | Low-density geochemical mapping in Portugal显示文摘 | Ferreira M M In?cio P Morgado M J | 2001 | Applied Geochemistry2001，16，： | 1 |
| 8 | Tire rubber-sisal composites: Effect of mercerization and acetylation on reinforcement显示文摘 | Maria A M Ines J | 2003 | Journal of Applied Polymer Science2003，89，9： | 1 |
| 9 | Bringing a probiotic- containing functional food to the market: microbiological, product, regulatory and labeling issues显示文摘 | Sanders M Huis in' t Veld J | 1999 | Antonie van Leeuwenhoek1999，76，： | 1 |
| 10 | Pitfalls and complicause of the proximal femoral nail显示文摘 | Windolf J dons in the Hollander DA Hakimi M | 2005 | Lxnt enhecks Arch Surt2005，390，3： | 1 |
| 11 | Multifractal scaling of soil spatial variability显示文摘 | CANIEGO F J ESPEJO R MART′IN M A | 2005 | Ecological Modelling2005，182，34： | 1 |
| 12 | Test conditions and instrumental parameters显示文摘 | Johnson JR Dettmar PW Factors affecting in vitro gastric mucoadhesion I | 1995 | Eur J Pharm Biopharm1995，41，4： | 1 |
| 13 | Part I:presentation of the model显示文摘 | Thome J R Dupont V Jacobi A M Heat transfer model for evaporation in microchannels | 2004 | Int J Heat Mass Transfer2004，47，1416： | 1 |
| 14 | flavicarpa) 显示文摘 | Trevisan F Mendes B M J Optimization of in vitro organogenesisin Passion fruit {Passiflora edulis f | 2005 | Sci Agric2005，62，： | 1 |
| 15 | With- drawal ofa novel - design duodenoscope ends outbreak of a VIM - 2 - producing Pseudomonas aeruginosa 显示文摘 | Verfaillie C J Bruno M J F Voor In I Hoh A el al | 2015 | Endosco-gy2015，47，6： | 1 |
| 16 | Simulating hydrologic and water quality impacts in an urbanizing watershed 显示文摘 | In S J Brannan K M Mostaghimi S | 2003 | Journal of the American Water Resources Association2003，39，6： | 1 |
| 17 | Day and night wind drift and evaporation losses in sprinkler solid-sets and moving laterals 显示文摘 | Play in E Salvador R Faci J M | 2005 | Agricultural Water Management2005，76，3： | 1 |
| 18 | Endoscopy显示文摘 | Gay G Delvaux M Rey J E The role of video capsule endoscopy in the diagnosis of digestive diseases: a review of current possibilities | 2004 | Endoscopy2004，36，4： | 1 |
| 19 | Flow rates East Pacific Rise(21°N) implications for the heat budget and the formation of massive sulfide deposits显示文摘 | Converse D R Holland H D in the axial hot springs of the Edmond J M | 1984 | Earth and Planet Science Letters1984，69，： | 1 |
| 20 | Effect o f microbial inoculants on quality of alfalfa hay baled at high moisture and cattle performance显示文摘 | Emanuele S M H or ton G M J Aldw in J | 1992 | J Dairy Sci1992，75，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员