|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients显示文摘BACKGROUND Persistent Helicobacter pylori(H.pylori)infection causes chronic inflammation,atrophy of the gastric mucosa,and a high risk of developing gastric cancer.In recent years,awareness of eradication therapy has increased in Japan.As H.pylori infections decrease,the proportion of gastric cancers arising from H.pylori uninfected gastric mucosa will increase.The emergence of gastric cancer arising in H.pylori uninfected patients though rarely reported,is a concern to be addressed and needs elucidation of its clinicopathological features.AIM To evaluate the clinicopathological features of early gastric cancer in H.pyloriuninfected patients.METHODS A total of 2462 patients with 3375 instances of early gastric cancers that were treated by endoscopic submucosal dissection were enrolled in our study between May 2000 and September 2019.Of these,30 lesions in 30 patients were diagnosed as H.pylori-uninfected gastric cancer(Hp UIGC).We defined a patient as H.pylori-uninfected using the following three criteria:(1)The patient did not receive treatment for H.pylori,which was determined by investigating medical recordsand conducting patient interviews;(2)Lack of endoscopic atrophy;and(3)The patient was negative for H.pylori after being tested at least twice using various diagnostic methods,including serum anti-H.pylori-Ig G antibody,urease breath test,rapid urease test,and microscopic examination.RESULTS The frequency of Hp UIGC was 1.2%(30/2462)for the patients in our study.The study included 19 males and 11 females with a mean age of 59 years.The location of the stomach lesions was divided into three sections;upper third(U),middle third(M),lower third(L).Of the 30 lesions,15 were U,1 was M,and 14 were L.Morphologically,17 lesions were protruded and flat elevated type(0-I,0-IIa,0-IIa+IIc),and 13 lesions were flat and depressed type(0-IIb,0-IIc).The median tumor diameter was 8 mm(range 2-98 mm).Histological analysis revealed that22 lesions(73.3%)were differentiated type.The Hp UIGC lesions were classified into fundic gland type adenocarcinoma(7 cases),foveolar type welldifferentiated adenocarcinoma(8 cases),intestinal phenotype adenocarcinoma(7 cases),and pure signet-ring cell carcinoma(8 cases).Among 30 Hp UIGCs,24 lesions(80%)were limited to the mucosa;wherein,the remaining 6 lesions showed submucosal invasion.One of the submucosal invasive lesions showed more than 500μm invasion.The mucin phenotype analysis identified 7 Hp UIGC with intestinal phenotype and 23 with gastric phenotype.CONCLUSION We elucidated the clinicopathological characteristics of Hp UIGC,revealing recognition not only undifferentiated-type but also differentiated-type.In addition,intestinal phenotype tumors were also observed and could be an important tip. | Chiko Sato Kingo Hirasawa Yoko Tateishi Yuichiro Ozeki Atsushi Sawada Ryosuke Ikeda Takehide Fukuchi Masafumi Nishio Ryosuke Kobayashi Makomo Makazu Hiroaki Kaneko Yoshiaki Inayama Shin Maeda | 2020 | World Journal of Gastroenterology2020，26，20： | 7 |
| 2 | Epithelioid angiomyolipoma of the kidney显示文摘 | Kato I Inayama Y Yamanaka S | 2009 | Pathol Int2009，59，1： | 1 |
| 3 | A case of adult onset idiopathic pulmonary hemosiderosis markedly improved by steroid therapy显示文摘 | Inayama M Hino H Takezaki A | 2007 | Nihon Kokyuki Gakkai Zasshi2007，45，： | 1 |
| 4 | Composite distal nephron-derived renal cell carcinoma with chromophobe and collecting duct carcinomatous elements显示文摘 | Inayama Y Nakaigawa N | 2005 | Pathol Int2005，55，6： | 1 |
| 5 | Epithelioid angiomyolipoma of the kidney显示文摘 | Kato I Inayama Y Yamanaka S | 2009 | Pathol Int2009，59，1： | 1 |
| 6 | A novel IkappaB kinasebeta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice显示文摘 | Inayama M Nishioka Y Azuma M | 2006 | Am J Respir Crit Care Med2006，173，9： | 1 |
| 7 | Interdigitating dendritic cell sarcoma of the spleen:report of a case with a review of the literature显示文摘 | Kawachi K Nakatani Y Inayama Y | 2002 | Am J Surg Pathol2002，26，4： | 1 |
| 8 | Epithelioid angiomyolipoma of the kidney显示文摘 | Kato I Inayama Y Yamanaka S | 2009 | Pathol Int2009，59，1： | 1 |
| 9 | Imatinib as a novel anti-fibrotic agent in bleomycin-induced pulmonary fibrosis in mice显示文摘 | Aono Y Nishioka Y Inayama M | 2005 | Am J Respir Crit Care Med2005，171，11： | 1 |
| 10 | Interdigitating dendritic cell sarcoma of the spleen:report of a case with a review of the literame显示文摘 | Kawachi K Nakatani Y Inayama Y | 2002 | Am J Surg Pathol2002，26，4： | 1 |
| 11 | Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia 显示文摘 | Hiroshi Yoneda Toshiaki Sakai | 1996 | Am J Med Gen( Neuropsychiatric genetice )1996，67，： | 1 |
| 12 | The lat- est technologies for process control and automation in blast furnace 显示文摘 | Yunosuke Maki Akihiro Inayama Katsurmi lno | 2000 | KAWASAKI Steel Technical Report2000，，43： | 1 |
| 13 | Postive associateion between a DNA sequence variant in the serotonin 2A receptor gene among schizophrenia显示文摘 | Inayama Y Yneda Sakia T | 1996 | Am J Med Genet1996，67，： | 1 |
| 14 | The lastest tech- nologies for process control and automation in blast furnace显示文摘 | Yunosuke Maki Akihiro Inayama Katsumi Ino | 2000 | KAWASAKI Steel Technical Report2000，1，43： | 1 |
| 15 | The Lastest Technologies for Process Control and Automation in Blast Furnace显示文摘 | Yunosuke Maki Akihiro Inayama | 2000 | Kawasaki Steel Technical Report2000，，43： | 1 |
| 16 | Epithelioid angiomyoli- poma of the kidney显示文摘 | Kato L Inayama Y Yamanaka S | 2009 | Pathol Int2009，59，12： | 1 |
| 17 | Interdigitating dendritic cell sarcoma of the spleen:report of a case with a review of the literature显示文摘 | Kawachi K Nakatani Y Inayama Y | 2002 | Am J Surg Patho2002，26，4： | 1 |
| 18 | Desmoplastic small round-cell tumor of the paratesticular region: report of an adult case with demonstration of EWS and WT1 gene fusion using paraffin-embedded tissue显示文摘 | Kawano N Inayama Y Nagashima Y | | 0，，： | 1 |
| 19 | Epithelioid angiomy- olipoma of the kidney显示文摘 | Kato I Inayama Y Yamanaka S | 2009 | Pathol Int2009，59，1： | 1 |
| 20 | Dietary intake of the flower extracts of German Chamomile inhibited compound 48/80-induced itchscratch responses in mice 显示文摘 | KOBAYASHI Y NAKANO Y INAYAMA K | 2003 | Phytomedieine2003，，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员