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| 1 | Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: Effect of bombesin and neurotensin显示文摘瞄准:调查试验性的妨碍的黄疸和外长的 bombesin 和 neurotensin (NT )(BBS ) 的影响紧密的连接(TJ ) 的表示上的管理在老鼠的肠上皮的蛋白质 claudin-4。方法:四十只男 Wistar 老鼠随机被划分成五个组:我 = 控制, II = 假冒操作, III = 胆汁管结扎(BDL ) , IV = BDL+BBS (30 microg/kg 每 d ) , V = BDL+NT (300 microg/kg 每 d ) 。在 d 的实验的结束 10,内毒素在门和大动脉的血被测量。终端回肠的织物节组织学地被检验并且免疫组织化学地为在肠上皮的 claudin-4 表示的评估。结果:妨碍的黄疸导致了重要的门和大动脉的 endotoxemia 表明的肠的障碍失败。Claudin-4 表示显著地被增加在上面在 jaundiced 老鼠的第三根绒毛并且一起来它的侧面的分发的规定被注意。BBS 或 NT 的管理恢复了 claudin-4 表示到控制状态并且显著地减少了门和大动脉的 endotoxemia。结论:在肠上皮的试验性的妨碍的黄疸增加 claudin-4 表示,它可以是贡献粘膜障碍的混乱的一个关键因素。毁坏规章的肽 BBS, NT 能阻止这扇改变和还原剂门和全身的 endotoxemia。 | Stelios F Assimakopoulos Constantine E Vagianos Aristides S Charonis Ilias H Alexandris Iris Spiliopoulou Konstantinos C Thomopoulos Vassiliki N Nikolopoulou Chrisoula D Scopa | 2006 | World Journal of Gastroenterology2006，12，21： | 21 |
| 2 | A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。 | Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy | 2012 | Molecular Plant2012，5，3： | 2 |
| 3 | An Algorithm for Diagnosis of System Failures in the Chemical Process显示文摘 | Iri M Aoki K O'shima E | 1979 | Comp Chem Eng1979，3，14： | 1 |
| 4 | Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways 显示文摘 | Nishida E Irie K | 1997 | Science1997，275，5296： | 1 |
| 5 | An Improved Algorithm For Diagnosis Of System Failures In The Chemical Process 显示文摘 | J SHIOZAKI H MATSUYAMA E O'SHIMA M IRI | 1985 | Computers & Chemical Engineering1985，9，： | 1 |
| 6 | An Algorithm For Diagnosis Of System Failures In The Chemical Process 显示文摘 | M IRI K AOKI E O'SHIMA H MATSUYAMA | 1979 | Computers &Chemical Engineering1979，3，： | 1 |
| 7 | I Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways显示文摘 | Ichijo H Nishida E Irie K ten Dijke P Saitoh M Moriguchi T | 1997 | Science1997，275，5296： | 1 |
| 8 | Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways显示文摘 | Ichijo H Nishida E Irie K | 1997 | Science1997，275，5296： | 1 |
| 9 | An algorithm for diagnosis of system failures in the chemical process显示文摘 | Iri M Aoki K O'shima E | 1979 | Computers and Chemical Engineering1979，3，14： | 1 |
| 10 | Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET显示文摘 | Nguyen T V Brownell A L Iris Chen Y C Livni E Coyle J T Rosen B R Cavagna F Jenkins B G | | 0，，01： | 1 |
| 11 | An algorithm for diagnosis of system failures in the chemical process显示文摘 | Iri M Aoki K O'shima E | 1979 | Computers and Chemical Engineering1979，3，14： | 1 |
| 12 | An algorithm for diagnosis of system failures in the chemical process显示文摘 | Iri M Aoki K O'Shima E | 1979 | Computers and Chemical Engineering1979，3，1234： | 1 |
| 13 | An algorithm for diagnosis of system failures in the chemical process显示文摘 | Iri M Aoki K O' Shima E | 1979 | Computers and Chemical Engineering1979，3，14： | 1 |
| 14 | A Graphical approach to the problem of locating the origin of the system failure显示文摘 | Iri M Aoki K O' Shima E | 1980 | Journal of the Operations Research1980，23，4： | 1 |
| 15 | An Algorithm for Diag nosis of System Failures in the Chemical Process 显示文摘 | M Iri K Aoki E O Shima H Matsuyama | 1979 | Computers & Chemical Engineering1979，3，： | 1 |
| 16 | Initial management of children with newly diagnosed idiopathic thrombocytopenic purpura in the Nordic countries显示文摘 | IRIS T R JUKKA R A BERNWARD Z E | 2006 | Acta Pediat2006，95，6： | 1 |
| 17 | Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/ JNK and p38 signaling pathways显示文摘 | Ichijo HE Nishisa E Irie K | 1997 | Science1997，275，5296： | 1 |
| 18 | An algorithm for diagnosis of system failures in the chemical process显示文摘 | Iri M Aoki K O'Shima E | 1979 | Computers & ChemicalEngineering1979，3，1： | 1 |
| 19 | Induction of apoptosis by ASK1,a mammalian MAPKKK that activates SAPK/JNK and p38 sigualing pathways显示文摘 | Ichijo H Nishida E Irie K | 1997 | Science1997，275，5296： | 1 |
| 20 | Role of nitric oxide, prostaglandins and tyrosine kinase in vascular endothelial growth factor-induced increase in vascular permeability in mouse skin显示文摘 | Fujii E Irie K Ohba K | 1997 | Naunyn Schmiede- bergs Arch Pharmacol1997，356，4： | 1 |
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