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| 1 | Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer显示文摘AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric cancer.METHODS From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant chemotherapy.RESULTS The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall survival.Disease-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who underwent adjuvant chemotherapy. High postoperative CEA levels were significantly associated with an increased prevalence of liver, lung and bone recurrences, and high postoperative CA19-9 levels were significantly associated with increased frequencies of lymph node and liver recurrences.CONCLUSION The evaluation of serum CEA and CA 19-9 levels both before and after surgery provides useful information for precise risk stratification after curative gastrectomy. | Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani Yasuhiro Kodera | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 7 |
| 2 | High bandwidth graded-index polymer optical fiber for near-infrared use显示文摘 | Eisuke Nihel Takaaki Ishigure and Yasuhiro Koike | 1996 | Applied Optics1996，35，36： | 1 |
| 3 | Polymer waveguide with 4-channel graded-index circular cores for parallel optical interconnects显示文摘 | Takaaki Ishigure Yusuke Takeyoshi | 2007 | Optical Express2007，15，9： | 1 |
| 4 | Index- profile design for low-loss crossed multimode waveguide for optical printed circuit board 显示文摘 | Takaaki Ishigure Keishiro Shitanda Yutaro Oizmi | 2015 | Optics Express2015，23，22： | 1 |
| 5 | Method for the preparation of optional fiber显示文摘 | Ishigure T Hirai M Sato M | 2004 | Journal of Applied Polymer Science2004，91，1： | 1 |
| 6 | Which is a more serious factor to the bandwidth of GI POF: differential mode attenuation or mode coupling? 显示文摘 | Ishigure T Kano M Koike Y | 2000 | J Lightwave Technol2000，18，7： | 1 |
| 7 | On-board fabrication of multi-channel polymer optical waveguide with graded-index cores by soft-lithography显示文摘 | Kakaaki Ishigure Yosuke Nitta | 2010 | Proceedings of 60th Electroni c Components and Technology Conference (ECTC) Las Vegas NV USA June 20102010，5281，： | 1 |
| 8 | High-bandwidth graded-index polymer optical fiber显示文摘 | Koike Y Ishigure T Nihei E | 1995 | J Lightw Technol1995，13，7： | 1 |
| 9 | Elevation of serum thrombopoi- etin precedes thrembocytosis in acute infections 显示文摘 | Ishigure A Suzuki Y Mito M | 2002 | Br J Haema- tol2002，116，3： | 1 |
| 10 | Calculation of the absorbed dose for the overexposed patients at the JCO criticality accident in Tokai-mura显示文摘 | Ishigure N Endo A Yamaguchi Y | 2001 | Journal of radiation research2001，42，2001： | 1 |
| 11 | A design of fine motion assist equipment for disabled hand in robotic rehabilitation system显示文摘 | Ito S Kawasaki H Ishigure Y | 2009 | Journal of the Franklinlnstitute2009，348，1： | 1 |
| 12 | High-bandwidth graded-index polymer optical fiber 显示文摘 | KOIKE Y ISHIGURE T NIHEI E | 1995 | J Lightwave Technol1995，13，7： | 1 |
| 13 | Optimum index profile of the per fluorinated polymer-based GI polymer optical fiber and its dispersion properties显示文摘 | Takaaki Ishigure | 2000 | Journal of Light-wave Technology2000，18，2： | 1 |
| 14 | High-bandwidth graded index polymer optical fiber for near infra-red use显示文摘 | Nihei E Ishigure T Koike Y | 1996 | Appl Opt1996，35，： | 1 |
| 15 | Survival of HER2-positive primary breast cancer patients treated by neoadjuvant chemothera- py plus trastuzumab : a multicenter retrospective observational study (JBCRG - C03 study ) 显示文摘 | Takada M Ishigure H Nagai S | 2014 | Breast Cancer Research and Treat- ment2014，145，1： | 1 |
| 16 | High bandwidth graded-index polymer optical fiber 显示文摘 | KOIKE Y ISHIGURE T NIHEI E | 1995 | IEEE J Lightwave Technology1995，13，9： | 1 |
| 17 | Optimum refractive-index profile of the graded-index polymer optical fiber, toward gigabit data links显示文摘 | ISHIGURE T NIHEI E KOIKE Y | 1996 | Appl Opt1996，35，12： | 1 |
| 18 | Fabrication of a grade d-index circular-core polymer parallel optical waveguide using a micro-dispenser for a high-density optical printed circuit board显示文摘 | Soma K Ishigure T | 2013 | IEEE J ournal of Selected Topics in Quantum Electronics2013，19，36： | 1 |
| 19 | High-bandwidth plastic optical fiber for fi- ber to the display显示文摘 | Koike Y Ishigure T | 2006 | J Lightw Technol2006，24，12： | 1 |
| 20 | Graded-index polymer optical fiber for high-speed data communication显示文摘 | ISHIGURE T NIHEI E KOIKE Y | 1994 | Appl Opt1994，33，19： | 1 |
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