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您的检索式：作者名="Iván Herrera"
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| 1 | New advances in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the leading cause of deaths in cirrhotic patients and the third cause of cancer related deaths.Most HCC are associated withwell known underlying risk factors,in fact,HCC arise in cirrhotic patients in up to 90%of cases,mainly due to chronic viral hepatitis and alcohol abuse.The worldwide prevention strategies are conducted to avoid the infection of new subjects and to minimize the risk of liver disease progression in infected patients.HCC is a condition which lends itself to surveillance as at-risk individuals can readily be identified.The American and European guidelines recommended implementation of surveillance programs with ultrasound every six months in patient atrisk for developing HCC.The diagnosis of HCC can be based on non-invasive criteria(only in cirrhotic patient)or pathology.Accurately staging patients is essential to oncology practice.The ideal tumour staging system in HCC needs to account for both tumour characteristics and liver function.Treatment allocation is based on several factors:Liver function,size and number of tumours,macrovascular invasion or extrahepatic spread.The recommendations in terms of selection for different treatment strategies must be based on evidence-based data.Resection,liver transplant and interventional radiology treatment are mainstays of HCC therapy and achieve the best outcomes in well-selected candidates.Chemoembolization is the most widely used treatment for unresectable HCC or progression after curative treatment.Finally,in patients with advanced HCC with preserved liver function,sorafenib is the only approved systemic drug that has demonstrated a survival benefit and is the standard of care in this group of patients. | Sonia Pascual Iván Herrera Javier Irurzun | 2016 | World Journal of Hepatology2016，8，9： | 51 |
| 2 | Seroprevalence of viral and bacterial pathogens among malaria patients in an endemic area of southern Venezuela显示文摘Background Malaria remains a leading public health problem worldwide.Co-infections with other pathogens complicate its diagnosis and may modify the disease’s clinical course and management.Similarities in malaria clinical presentation with other infections and overlapping endemicity result in underdiagnosis of co-infections and increased mortality.Thus,the aim of this study was to determine the seroprevalence of viral and bacterial pathogens among diagnosed malaria patients in malaria-endemic areas in Venezuela.Methods A cross-sectional study was conducted on malaria patients attending three reference medical centres in Ciudad Bolivar,Venezuela.Clinical evaluation and laboratory tests for dengue virus(DENV),chikungunya virus(CHIKV),viral hepatitis[hepatitis A virus(HAV),hepatitis B virus(HBV),and hepatitis C virus(HCV)],and leptospirosis(LEP)were performed by enzyme-linked immunosorbent assays.Previous exposure to these pathogens was defined by the presence of specific immunoglobulin(Ig)G,and co-infection or recent exposure(CoRE)was determined by the presence of specific IgM alone or IgM+IgG.Data analysis considered descriptive statistics.Parameter distribution was statistically evaluated using Kolmogorov–Smirnov test and the necessary comparison tests.Odds ratio(OR)for complications was determined according to CoRE presence with a 95%confidence interval(CI).Results A total of 161 malaria patients were studied,66%infected with Plasmodium vivax,27%with P.falciparum,and 7.5%harboured P.vivax/P.falciparum mixed infection.Previous exposure to DENV(60%)and CHIKV(25%)was frequent.CoRE was confirmed in 55 of the 161 malaria patients(34%)and were more frequent in P.falciparum(49%)than in P.vivax(29%)and mixed malaria patients(25%)(OR=2.43,95%CI:1.39–4.25,P=0.018).The most frequent CoRE was DENV(15%),followed by HAV(12%),HBV(6.2%),CHIKV(5.5%),and LEP(3.7%);HCV CoRE was absent.Complicated malaria was significantly more frequent in patients with CoRE(56%)than those without CoRE(36%;OR=2.31,95%CI:1.18–4.92,P=0.013).Conclusions We found high CoRE prevalence in malaria patients as determined by serology in the study region;cases were associated with a worse clinical outcome.Further prospective studies with samples from different infection sites and the use of molecular tools are needed to determine the clinical significance of these findings. | David A.Forero-Peña Fhabián S.Carrión-Nessi Mary Lopez-Perez Marisol Sandoval-de Mora Iván D.Amaya Ángel F.Gamardo Melynar Chavero Luisamy Figuera María V.Marcano Natasha A.Camejo-Ávila Mariana Hidalgo Cariagne J.Arenas Myriam Arévalo-Herrera Sócrates Herrera | 2023 | Infectious Diseases of Poverty2023，12，2： | 0 |
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