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您的检索式：作者名="Jóhannes Reynisson"
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| 1 | Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation显示文摘The guanine radical cation(G?+)is formed by one-electron oxidation from its parent guanine(G).G?+is rapidly deprotonated in the aqueous phase resulting in the formation of the neutral guanine radical[G(-H)?].The loss of proton occurs at the N1 nitrogen,which is involved in the classical Watson-Crick base pairing with cytosine(C).Employing the density functional theory(DFT),it has been observed that a new shifted base pairing configuration is formed between G(-H)?and C constituting only two hydrogen bonds after deprotonation occurs.Using the DFT method,G(-H)?was paired with thymine(T),adenine(A)and G revealing substantial binding energies comparable to those of classical G-C and A-T base pairs.Hence,G(-H)?does not display any particular specificity for C compared to the other bases.Taking into account the long lifetime of the G(-H)?radical in the DNA helix(5 s)and the rapid duplication rate of DNA during mitosis/meiosis(5-500 bases per s),G(-H)?can pair promiscuously leading to errors in the duplication process.This scenario constitutes a new mechanism which explains how one-electron oxidation of the DNA double helix can lead to mutations. | Jóhannes Reynisson | 2010 | World Journal of Clinical Oncology2010，1，1： | 0 |
| 2 | Serendipity in anticancer drug discovery显示文摘It was found that the discovery of 5.8%(84/1437) of all drugs on the market involved serendipity. Of these drugs, 31(2.2%) were discovered following an incident in the laboratory and 53(3.7%) were discovered in a clinical setting. In addition, 263(18.3%) of the pharmaceuticals in clinical use today are chemical derivatives of the drugs discovered with the aid of serendipity. Therefore, in total, 24.1%(347/1437) of marketed drugs can be directly traced to serendipitous events confirming the importance of this elusive phenomenon. In the case of anticancer drugs, 35.2%(31/88) can be attributed to a serendipitous event, which is somewhat larger than for all drugs. The therapeutic field that has benefited the most from serendipity are central nervous system active drugs reflecting the difficulty in designing compounds to pass the blood-brain-barrier and the lack of laboratory-based assays for many of the diseases of the mind. | Emily Hargrave-Thomas Bo Yu Jóhannes Reynisson | 2012 | World Journal of Clinical Oncology2012，3，1： | 0 |
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